AiPD: Autoinhibited Protein Database

Gene name	Slc34a2 (Npt2b)
Protein name	Sodium-dependent phosphate transport protein 2B
Names	Sodium-phosphate transport protein 2B, Na(+)-dependent phosphate cotransporter 2B, Sodium/phosphate cotransporter 2B, Na(+)/Pi cotransporter 2B, NaPi-2b, Solute carrier family 34 member 2
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:20531
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-108 (Predicted disordered autoinhibitory region) PR

1-108 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9DBP0-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388761827	9	N>I	No	EVA
rs3388766886	12	P>S	No	EVA
rs3388758354	23	G>*	No	EVA
rs237786757	41	N>S	No	EVA
rs3388732497	64	P>L	No	EVA
rs3388766940	68	D>E	No	EVA
rs3388732459	82	W>*	No	EVA
rs3413077310	100	K>*	No	EVA
rs3388732479	122	F>L	No	EVA
rs3388766927	158	Q>H	No	EVA
rs226014849	180	A>T	No	EVA
rs3388759412	186	M>I	No	EVA
rs3388745798	198	I>V	No	EVA
rs3388759781	213	A>G	No	EVA
rs3388766929	222	F>I	No	EVA
rs3388755047	224	N>K	No	EVA
rs258152912	229	F>L	No	EVA
rs3395528714	230	V>L	No	EVA
rs3388764481	251	T>N	No	EVA
rs3388754674	256	N>D	No	EVA
rs3388761789	274	L>I	No	EVA
rs3388761679	298	L>M	No	EVA
rs254114551	319	T>P	No	EVA
rs3388764493	334	Q>E	No	EVA
rs3388766911	383	I>T	No	EVA
rs3388764564	387	L>M	No	EVA
rs3388758398	409	F>Y	No	EVA
rs3388761673	478	G>C	No	EVA
rs3388761612	478	G>D	No	EVA
rs3388732478	492	F>V	No	EVA
rs3412877954	509	R>H	No	EVA
rs3388754653	512	I>F	No	EVA
rs3388764496	560	V>I	No	EVA
rs3388762248	577	F>I	No	EVA
rs3388761785	598	H>Y	No	EVA
rs3388761336	599	S>Y	No	EVA

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q9DBP0

		Description
EC Number
Subcellular Localization	Apical cell membrane ; Multi-pass membrane protein	Localized at the brush border membranes of enterocytes
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
apical plasma membrane	The region of the plasma membrane located at the apical end of the cell.
brush border	The dense covering of microvilli on the apical surface of an epithelial cell in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell.
brush border membrane	The portion of the plasma membrane surrounding the brush border.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
microvillus membrane	The portion of the plasma membrane surrounding a microvillus.
vesicle	Any small, fluid-filled, spherical organelle enclosed by membrane.

Name	Definition
phosphate ion binding	Binding to a phosphate ion.
protein domain specific binding	Binding to a specific domain of a protein.
sodium ion binding	Binding to a sodium ion (Na+).
sodium:phosphate symporter activity	Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + phosphate(out) = Na+(in) + phosphate(in).

Name	Definition
cellular phosphate ion homeostasis	Any process involved in the maintenance of an internal steady state of phosphate ions at the level of a cell.
in utero embryonic development	The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
phosphate ion transport	The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
response to estrogen	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics.
sodium-dependent phosphate transport	The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, by a mechanism dependent upon sodium ions.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
O95436	SLC34A2	Sodium-dependent phosphate transport protein 2B	Homo sapiens (Human)	PR
Q9JJ09	Slc34a2	Sodium-dependent phosphate transport protein 2B	Rattus norvegicus (Rat)	PR