AiPD: Autoinhibited Protein Database

Gene name	Ftsj3
Protein name	pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3
Names	Protein ftsJ homolog 3, Putative rRNA methyltransferase 3
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:56095
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

300-370 (Predicted disordered autoinhibitory region) PR

300-370 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9DBE9-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs13471824	31	K>E	No	EVA
rs3389204353	117	D>G	No	EVA
rs3389211205	121	N>Y	No	EVA
rs3389211210	153	C>*	No	EVA
rs3389171832	179	Q>R	No	EVA
rs3389211198	186	S>T	No	EVA
rs3389220451	195	V>L	No	EVA
rs3389185519	212	D>E	No	EVA
rs3389593561	243	E>G	No	EVA
rs3389211184	285	A>T	No	EVA
rs3389213177	312	R>I	No	EVA
rs218259651	333	S>N	No	EVA
rs3389210845	389	L>R	No	EVA
rs3402747620	430	L>*	No	EVA
rs3389208462	478	V>L	No	EVA
rs3389226482	485	K>N	No	EVA
rs27010762	489	Y>C	No	EVA
rs220234408	493	T>A	No	EVA
rs248436209	494	Q>K	No	EVA
rs230849596	502	E>G	No	EVA
rs3389198429	514	K>R	No	EVA
rs3389221998	525	W>*	No	EVA
rs3389224438	537	D>E	No	EVA
rs27010763	555	Q>R	No	EVA
rs3402635108	556	K>T	No	EVA
rs3389220446	591	L>S	No	EVA
rs3389171826	613	S>N	No	EVA
rs3389146793	653	I>T	No	EVA
rs3389181259	656	P>R	No	EVA
rs3389211220	666	A>T	No	EVA
rs3413143545	684	A>V	No	EVA
rs3389204349	701	K>R	No	EVA
rs3389185486	735	E>D	No	EVA
rs3389211209	735	E>Q	No	EVA
rs250446423	744	V>M	No	EVA
rs3389146780	770	V>M	No	EVA
rs3402729344	775	S>R	No	EVA
rs3402350168	777	Y>*	No	EVA
rs3389211271	784	K>E	No	EVA
rs3389198447	795	K>Q	No	EVA
rs3389204344	796	K>N	No	EVA
rs27010765	809	K>R	No	EVA
rs3389185490	810	G>D	No	EVA
rs3389206599	823	Q>H	No	EVA
rs3389213166	833	K>I	No	EVA

Type	Name	Position	InterPro Accession
domain	Ribosomal RNA methyltransferase, FtsJ domain	24 - 200	IPR002877
domain	Ribosomal RNA methyltransferase, SPB1-like, C-terminal	617 - 830	IPR012920
domain	Ribosomal RNA methyltransferase Spb1, domain of unknown function DUF3381	232 - 398	IPR024576

		Description
EC Number
Subcellular Localization	Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
chromosome	A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
preribosome, large subunit precursor	A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit.
preribosome, small subunit precursor	A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit.

Name	Definition
RNA 2'-O-methyltransferase activity	Catalysis of the reaction: S-adenosyl-L-methionine + RNA = S-adenosyl-L-homocysteine + RNA containing 2'-O-methylribonucleotide.
RNA methyltransferase activity	Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule.
rRNA (guanine) methyltransferase activity	Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methylguanine.
rRNA (uridine-2'-O-)-methyltransferase activity	Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methyluridine.

Name	Definition
enzyme-directed rRNA 2'-O-methylation	The addition of methyl groups to the 2'-oxygen atom of nucleotide residues in an rRNA molecule during ribosome biogenesis where the methylase specifies the site that becomes methylated without using a guide RNA.
maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	Any process involved in the maturation of an rRNA molecule originally produced as part of a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.
maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.
RNA methylation	Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor.
rRNA methylation	The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q5ZKM1	FTSJ3	pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3	Gallus gallus (Chicken)	PR
Q8IY81	FTSJ3	pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3	Homo sapiens (Human)	PR