Q5ZKM1
Gene name |
FTSJ3 |
Protein name |
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 |
Names |
Protein ftsJ homolog 3, Putative rRNA methyltransferase 3 |
Species |
Gallus gallus (Chicken) |
KEGG Pathway |
gga:419943 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5ZKM1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5ZKM1-F1 | Predicted | AlphaFoldDB |
No variants for Q5ZKM1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5ZKM1 | |||||
No associated diseases with Q5ZKM1
3 regional properties for Q5ZKM1
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| preribosome, large subunit precursor | A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit. |
| preribosome, small subunit precursor | A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| RNA 2'-O-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + RNA = S-adenosyl-L-homocysteine + RNA containing 2'-O-methylribonucleotide. |
| RNA methyltransferase activity | Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. |
| rRNA (guanine) methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methylguanine. |
| rRNA (uridine-2'-O-)-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methyluridine. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| enzyme-directed rRNA 2'-O-methylation | The addition of methyl groups to the 2'-oxygen atom of nucleotide residues in an rRNA molecule during ribosome biogenesis where the methylase specifies the site that becomes methylated without using a guide RNA. |
| maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Any process involved in the maturation of an rRNA molecule originally produced as part of a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. |
| maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript. |
| RNA methylation | Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor. |
| rRNA methylation | The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGKKSKVGKS | RRDKFYHLAK | ETGFRSRSAF | KLLQLNRKFQ | FLQKARALLD | LCAAPGGWLQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VASKFMPVSS | LVIGVDLVPI | KPIPNVVTLQ | EDITTEKCRQ | ALRKELQTWK | VDVVLNDGAP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NVGASWVHDA | YSQANLTLMA | LKLACEFLCK | GGWFITKVFR | SRDYQPLLWI | FQQFFHKVQA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TKPQASRNES | AEIFVVCQGY | QAPDKIDSKF | FDPKYAFKEV | EVHAKSVSEL | VSKKKPKAEG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YADGDTTLYH | RFTLMDFLKA | PNPVDFLSKA | NEITLGDGEL | ENHSSTTEEL | RQCCKDIRVL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GRKELRALLN | WRTKLRRFLT | KKLKEQAKEL | DINLSSGEEE | EGREEEEKTS | PKAAADEMVK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EEEEEVELAL | AEMKAKELAE | LKRKKKKILK | EQRKQRERVE | LKMDLPGVSI | ADDGDTSMFS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LQTIQRTQLL | NEVARGDMAS | ADALLEMRPG | DDDICVSDAD | DEDDVSLASD | LDPEELVEIE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ARQRRLERER | REQGVKRVKP | KVEEEEEEEE | EEENPLLVPL | EEKSVLQERQ | TSLWFGKDAF |
| 550 | 560 | 570 | 580 | 590 | 600 |
| AGIEDDADED | LELGQSQMLA | ERQRESQTGK | TKKKGQKKKV | PQESTAAEPQ | DAADTGADTA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| EAEAEQSSDD | DSSSDEEGPP | TPVGRKRGLV | EPCGFEVVPI | EDPVKKARVL | DAEGLALGSV |
| 670 | 680 | 690 | 700 | 710 | 720 |
| IATSKKAKRD | LIDDSFNRYS | FNEEEGELPE | WFTEEEKQHR | RKQIPLDKQT | VEEYRQRWRQ |
| 730 | 740 | 750 | 760 | 770 | 780 |
| INARPIKKVA | EAKARKKRRM | LKKMEQMKKK | AEAVVSTVDI | SEREKVAQLR | RIYKKAGLGK |
| 790 | 800 | 810 | 820 | 830 | |
| EKRQVTYLVA | KKGVGPRVRR | PPGVKGQFKV | VDSRLKKDVR | AQKRKEQKKR | RK |