AiPD: Autoinhibited Protein Database

Gene name	Dennd6b
Protein name	Protein DENND6B
Names	DENN domain-containing protein 6B
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:69440
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-65 (Predicted disordered autoinhibitory region) PR

1-65 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9D9V7-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389382111	10	R>G	No	EVA
rs32058829	22	S>T	No	EVA
rs235847037	31	A>T	No	EVA
rs3389387894	41	W>*	No	EVA
rs3389344847	59	E>G	No	EVA
rs3389382062	64	S>C	No	EVA
rs3389344859	83	D>Y	No	EVA
rs3389381223	94	F>I	No	EVA
rs3389397315	100	Q>E	No	EVA
rs3389376484	101	C>*	No	EVA
rs3389372719	121	L>*	No	EVA
rs235097122	170	S>N	No	EVA
rs3389392757	171	L>Q	No	EVA
rs3389372661	196	A>T	No	EVA
rs3406371406	207	I>T	No	EVA
rs3389382086	223	L>R	No	EVA
rs3389397317	233	Q>H	No	EVA
rs3389372728	241	V>L	No	EVA
rs3389397353	244	T>I	No	EVA
rs3389382115	246	V>A	No	EVA
rs3389387827	250	D>V	No	EVA
rs586830908	261	H>L	No	EVA
rs3389372706	289	V>M	No	EVA
rs3389332759	336	P>R	No	EVA
rs3389362817	355	K>N	No	EVA
rs3389387899	407	R>L	No	EVA
rs3389362834	423	L>I	No	EVA
rs3389392800	442	Q>*	No	EVA
rs3389300023	464	R>*	No	EVA
rs3389376466	466	L>V	No	EVA
rs3389375447	468	H>R	No	EVA
rs3389375448	499	R>Q	No	EVA
rs3389375377	549	Q>H	No	EVA
rs3389375397	566	Y>F	No	EVA
rs3389380263	566	Y>H	No	EVA
rs3389362832	570	V>A	No	EVA
rs3389362855	579	Q>R	No	EVA

Type	Name	Position	InterPro Accession
domain	AVL9/DENND6 domain	43 - 179	IPR018307
domain	Tripartite DENN domain	43 - 499	IPR037516

		Description
EC Number
Subcellular Localization	Recycling endosome Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
recycling endosome	An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane.

Name	Definition
guanyl-nucleotide exchange factor activity	Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.

Name	Definition
No GO annotations for biological process

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q5F3L4	DENND6A	Protein DENND6A	Gallus gallus (Chicken)	PR
Q8IWF6	DENND6A	Protein DENND6A	Homo sapiens (Human)	PR
Q8NEG7	DENND6B	Protein DENND6B	Homo sapiens (Human)	PR
Q8BH65	Dennd6a	Protein DENND6A	Mus musculus (Mouse)	PR