Q5F3L4

PR
Gene name
DENND6A (RCJMB04_14d15)
Protein name
Protein DENND6A
Names
DENN domain-containing protein 6A
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:416006
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-53 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5F3L4

Entry ID Method Resolution Chain Position Source
AF-Q5F3L4-F1 Predicted AlphaFoldDB

No variants for Q5F3L4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5F3L4

No associated diseases with Q5F3L4

2 regional properties for Q5F3L4

Type Name Position InterPro Accession
domain AVL9/DENND6 domain 40 - 176 IPR018307
domain Tripartite DENN domain 39 - 504 IPR037516

Functions

Description
EC Number
Subcellular Localization
  • Recycling endosome
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
recycling endosome An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane.

1 GO annotations of molecular function

Name Definition
guanyl-nucleotide exchange factor activity Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8NEG7 DENND6B Protein DENND6B Homo sapiens (Human) PR
Q8IWF6 DENND6A Protein DENND6A Homo sapiens (Human) PR
Q9D9V7 Dennd6b Protein DENND6B Mus musculus (Mouse) PR
Q8BH65 Dennd6a Protein DENND6A Mus musculus (Mouse) PR
10 20 30 40 50 60
MALWERGAGG AAEAGEDATE EPERGLPLLP WDRFSAWLHC VCVVGFDLEL GQAVEVIYPP
70 80 90 100 110 120
HSKLTDKEKT NICYLSFPDS NSGCLGDTQF CFRFRRSSGR KASLCCFLDH LDRDLPVYLK
130 140 150 160 170 180
KDPAYYYGYV YFRQVRDKSL KRGYFQKSLV LISKLPYIHL FRTVLKQIAP EYFEKSEAFL
190 200 210 220 230 240
EAVCSDVDRW PPPVPGEVLH LPIMGVVMKL RIPTYRDKPG TTPVVQNMHQ ADAQISMTLP
250 260 270 280 290 300
TVHEVDLFRC FCPVFFHIQM LWELVLLGEP LVVMAPSPAE SSETVLALVS CISPLKYCSD
310 320 330 340 350 360
FRPYFTIHDS EFKEYTTRTQ APPSVILGVT NPFFAKTLQH WPHIIRIGDM KLPGDVPKQV
370 380 390 400 410 420
KVKKLKNLKT LDSKPGVYTS YKPYLDKDEE IVKQLQKGVQ QKRPTEAQSA ILRRYFLELT
430 440 450 460 470 480
ESFIIPLERY VASLMPLQKC ISPWKSPPQL RHFSQDDFMK TLEKAGPQLT SGLKGDWIGL
490 500 510 520 530 540
YRHFLKSPNF DGWFRSRQKE MTQNLEALHL EALCNENLVF WSQKHTEVET VDLVLKLKNK
550 560 570 580
LLQADREHLP VKTDTLKKLQ THIRDIILAL PDDLQDILLK TGTA