AiPD: Autoinhibited Protein Database

Gene name	Dennd6a
Protein name	Protein DENND6A
Names	DENN domain-containing protein 6A
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:211922
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-71 (Predicted disordered autoinhibitory region) PR

1-71 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8BH65-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs264383310	10	G>E	No	EVA
rs3389308075	80	P>H	No	EVA
rs3389296853	87	D>V	No	EVA
rs3389296883	132	F>S	No	EVA
rs3389296882	155	Q>K	No	EVA
rs3389267595	156	V>I	No	EVA
rs3404894380	183	H>Q	No	EVA
rs3404985994	185	V>I	No	EVA
rs3405008289	189	I>M	No	EVA
rs3412823864	190	A>V	No	EVA
rs3404894349	191	P>L	No	EVA
rs3404677886	193	Y>*	No	EVA
rs3404894362	194	F>C	No	EVA
rs3404209700	199	P>SKL*	No	EVA
rs3404466581	199	P>Y	No	EVA
rs3389314836	224	I>F	No	EVA
rs1134167351	274	P>S	No	EVA
rs3389324936	276	F>L	No	EVA
rs1134779378	276	F>S	No	EVA
rs1134779378	276	F>Y	No	EVA
rs1133507098	278	H>L	No	EVA
rs1134107071	280	Q>H	No	EVA
rs3389309206	349	G>R	No	EVA
rs3389308113	403	K>N	No	EVA
rs3389328861	409	D>Y	No	EVA
rs3389319978	428	A>V	No	EVA
rs3389314681	445	I>N	No	EVA
rs3389238794	474	F>I	No	EVA
rs3389308097	492	S>F	No	EVA
rs3404889701	508	S>P	No	EVA
rs3404803401	510	N>I	No	EVA
rs3389296906	558	L>Q	No	EVA
rs3389328907	560	N>I	No	EVA

Type	Name	Position	InterPro Accession
domain	AVL9/DENND6 domain	43 - 179	IPR018307
domain	Tripartite DENN domain	43 - 499	IPR037516

		Description
EC Number
Subcellular Localization	Recycling endosome Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
intracellular membrane-bounded organelle	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
recycling endosome	An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane.

Name	Definition
guanyl-nucleotide exchange factor activity	Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.

Name	Definition
positive regulation of cell-cell adhesion mediated by cadherin	Any process that activates or increases the frequency, rate or extent of cell-cell adhesion mediated by cadherin.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q5F3L4	DENND6A	Protein DENND6A	Gallus gallus (Chicken)	PR
Q8NEG7	DENND6B	Protein DENND6B	Homo sapiens (Human)	PR
Q8IWF6	DENND6A	Protein DENND6A	Homo sapiens (Human)	PR
Q9D9V7	Dennd6b	Protein DENND6B	Mus musculus (Mouse)	PR