Q9D6Z1
Gene name |
Nop56 (Nol5a) |
Protein name |
Nucleolar protein 56 |
Names |
Nucleolar protein 5A |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:67134 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9D6Z1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9D6Z1-F1 | Predicted | AlphaFoldDB |
17 variants for Q9D6Z1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388580134 | 33 | E>K | No | EVA | |
| rs3392211879 | 65 | N>K | No | EVA | |
| rs3388587981 | 69 | E>G | No | EVA | |
| rs3388580147 | 83 | Y>* | No | EVA | |
| rs3392211878 | 96 | G>A | No | EVA | |
| rs3392275566 | 96 | G>R | No | EVA | |
| rs3388584357 | 169 | I>N | No | EVA | |
| rs3392275569 | 193 | Y>* | No | EVA | |
| rs3388593992 | 194 | G>E | No | EVA | |
| rs3388588017 | 237 | D>V | No | EVA | |
| rs3388588019 | 325 | T>I | No | EVA | |
| rs3388592765 | 361 | A>P | No | EVA | |
| rs3388587963 | 422 | K>* | No | EVA | |
| rs3388593987 | 427 | Q>R | No | EVA | |
| rs27275797 | 436 | T>A | No | EVA | |
| rs3388588433 | 446 | R>H | No | EVA | |
| rs3388595675 | 531 | K>N | No | EVA |
No associated diseases with Q9D6Z1
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| box C/D RNP complex | A ribonucleoprotein complex containing a box C/D type RNA that can carry out ribose-2'-O-methylation of target RNAs. Box C/D type RNAs are widespread in eukaryotes and in Archaea, suggesting that an RNA-based guide mechanism for directing specific RNA 2'-O-ribose methylations was present in the common ancestor of Archaea and Eukarya. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| fibrillar center | A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| pre-snoRNP complex | A ribonucleoprotein complex that contains a precursor small nucleolar RNA (pre-snoRNA) and associated proteins, and forms during small nucleolar ribonucleoprotein complex (snoRNP) assembly. Pre-snoRNP complexes may contain proteins not found in the corresponding mature snoRNP complexes. |
| small-subunit processome | A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. |
| sno(s)RNA-containing ribonucleoprotein complex | A ribonucleoprotein complex that contains an RNA molecule of the snoRNA family and associated proteins. Many are involved in a step of processing of rRNA molecules: cleavage, 2'-O-methylation, or pseudouridylation, but other RNA types can be targets as well. The majority fall into one of two classes, box C/D type or box H/ACA type, which are conserved across eukaryotes and archaea. Other members include the telomerase RNA and the ribonuclease MRP RNA. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| histone methyltransferase binding | Binding to a histone methyltransferase enzyme. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| snoRNA binding | Binding to a small nucleolar RNA. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| ribosome biogenesis | A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis. |
3 homologous proteins in AiPD
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVLLHVLFEH | AVGYALLALK | EVEEISLLLP | QVEECVLNLG | KFHNVVRLVA | FCPFSSSQVA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LENANAVSEG | VVHEDLRLLL | ETYLPSKKKK | VLLGVGDPKI | GAAIQEELGY | NCQTGGVIAE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ILRGVRLHFH | NLVKGLTDLS | ACKAQLGLGH | SYSRAKVKFN | VNRVDNMIIQ | SISLLDQLDK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DINTFSMRVR | EWYGYHFPEL | VKIVNDNATY | CRLAQFIGNR | RELNEEKLEK | LEEITMDGAK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AKAILDASRS | SMGMDISAID | LINIESFSSR | VVSLSEYRQS | LHTYLRSKMS | QVAPSLSALI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GEAVGARLIA | HAGSLTNLAK | YPASTVQILG | AEKALFRALK | TRGNTPKYGL | IFHSTFIGRA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AAKNKGRISR | YLANKCSIAS | RIDCFSEVPT | SVFGEKLREQ | VEERLSFYET | GEIPRKNLDV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| MKEAVVQAEE | AAAEITRKLE | KQEKKRLKKE | KKRLAALALA | SSENSSTPEE | CEEVNEKSKK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KKKLKPQENG | MEDPPVSLPK | SKKKKAPKEE | LASDLEEMAT | SSAKRKKSSP | KEEVASEPEE |
| 550 | 560 | 570 | |||
| AASPTTPKKK | RKFSEEPEVA | ANFTKSSTKK | KKKSQKAQED |