Q6DFW4
PR
Gene name |
Nop58 (Nol5) |
Protein name |
Nucleolar protein 58 |
Names |
MSSP, Nucleolar protein 5, SIK-similar protein |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:55989 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6DFW4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6DFW4-F1 | Predicted | AlphaFoldDB |
15 variants for Q6DFW4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388472107 | 7 | T>R | No | EVA | |
| rs3388472893 | 154 | S>I | No | EVA | |
| rs3388473282 | 235 | K>T | No | EVA | |
| rs3388472692 | 246 | V>A | No | EVA | |
| rs3388474481 | 253 | N>D | No | EVA | |
| rs1132275091 | 277 | N>K | No | EVA | |
| rs1132830410 | 278 | R>L | No | EVA | |
| rs1132572732 | 284 | P>H | No | EVA | |
| rs1135246443 | 284 | P>T | No | EVA | |
| rs1134251223 | 292 | E>G | No | EVA | |
| rs3388472941 | 332 | R>K | No | EVA | |
| rs3390043848 | 333 | R>* | No | EVA | |
| rs13465508 | 385 | I>V | No | EVA | |
| rs3390021605 | 403 | I>K | No | EVA | |
| rs3388472855 | 512 | E>V | No | EVA |
No associated diseases with Q6DFW4
10 GO annotations of cellular component
| Name | Definition |
|---|---|
| box C/D RNP complex | A ribonucleoprotein complex containing a box C/D type RNA that can carry out ribose-2'-O-methylation of target RNAs. Box C/D type RNAs are widespread in eukaryotes and in Archaea, suggesting that an RNA-based guide mechanism for directing specific RNA 2'-O-ribose methylations was present in the common ancestor of Archaea and Eukarya. |
| Cajal body | A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| fibrillar center | A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| pre-snoRNP complex | A ribonucleoprotein complex that contains a precursor small nucleolar RNA (pre-snoRNA) and associated proteins, and forms during small nucleolar ribonucleoprotein complex (snoRNP) assembly. Pre-snoRNP complexes may contain proteins not found in the corresponding mature snoRNP complexes. |
| small-subunit processome | A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. |
| sno(s)RNA-containing ribonucleoprotein complex | A ribonucleoprotein complex that contains an RNA molecule of the snoRNA family and associated proteins. Many are involved in a step of processing of rRNA molecules: cleavage, 2'-O-methylation, or pseudouridylation, but other RNA types can be targets as well. The majority fall into one of two classes, box C/D type or box H/ACA type, which are conserved across eukaryotes and archaea. Other members include the telomerase RNA and the ribonuclease MRP RNA. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATPase binding | Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP. |
| snoRNA binding | Binding to a small nucleolar RNA. |
| TFIID-class transcription factor complex binding | Binding to a general RNA polymerase II transcription factor belonging to the TFIID complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| ribosome biogenesis | A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis. |
| snoRNA localization | Any process in which small nucleolar RNA is transported to, or maintained in, a specific location. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLVLFETSVG | YAIFKVLNEK | KLQEVDSLWK | EFETPEKANK | IVKLKHFEKF | QDTAEALAAF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TALMEGKINK | QLKKVLKKIV | KEAHEPLAVA | DAKLGGVIKE | KLNLSCIHSP | VVNELMRGIR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SQMDGLIPGV | EPREMAAMCL | GLAHSLSRYR | LKFSADKVDT | MIVQAISLLD | DLDKELNNYI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| MRCREWYGWH | FPELGKIISD | NLTYCKCLQK | VGDRKNYASA | SLSEFLSEEV | EAEVKAAAEI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SMGTEVSEED | ICNILHLCTQ | VIEISEYRTQ | LYEYLQNRMM | AIAPNVTVMV | GELVGARLIA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| HAGSLLNLAK | HAASTVQILG | AEKALFRALK | SRRDTPKYGL | IYHASLVGQS | SPKHKGKISR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| MLAAKTVLAI | RYDAFGEDSS | SAMGIENRAK | LEARLRILED | RGIRKISGTG | KALAKAEKYE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| HKSEVKTYDP | SGDSTLPTCS | KKRKIEEVDK | EDEITEKKAK | KAKIKIKAEV | EEEMEEEEAE |
| 490 | 500 | 510 | 520 | 530 | |
| EEQVVEEEPT | VKKKKKKDKK | KHIKEEPLSE | EEPCTSTAVP | SPEKKKKKKK | KKDAED |