AiPD: Autoinhibited Protein Database

Gene name	Gbe1
Protein name	1,4-alpha-glucan-branching enzyme
Names	Brancher enzyme, Glycogen-branching enzyme
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:74185
EC number	2.4.1.18: Hexosyltransferases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-47 (Predicted disordered autoinhibitory region) PR

1-47 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9D6Y9-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs265003638	10	G>E	No	EVA
rs221292929	14	P>L	No	EVA
rs229232227	131	N>S	No	EVA
rs3389336865	133	S>P	No	EVA
rs214562831	135	L>P	No	EVA
rs251789732	145	V>F	No	EVA
rs13459309	177	H>Q	No	EVA
rs3407179514	224	L>P	No	EVA
rs3389422823	247	A>T	No	EVA
rs3407058392	268	E>G	No	EVA
rs3389439423	272	L>F	No	EVA
rs3389433695	276	A>G	No	EVA
rs13459310	318	T>I	No	EVA
rs3389336901	410	I>L	No	EVA
rs3389381949	437	M>K	No	EVA
rs3389391565	452	D>E	No	EVA
rs3389433685	506	L>M	No	EVA
rs3389371946	507	A>P	No	EVA
rs3389426230	508	P>H	No	EVA
rs3389403289	509	F>I	No	EVA
rs3389422355	510	T>P	No	EVA
rs3389391439	517	I>L	No	EVA
rs3389433719	547	E>G	No	EVA
rs3389420633	589	R>S	No	EVA
rs3389417418	622	L>I	No	EVA
rs253234232	645	K>N	No	EVA
rs3413052178	667	T>I	No	EVA
rs13459311	668	N>D	No	EVA
rs3389417349	670	F>S	No	EVA
rs3389420708	693	L>P	No	EVA
rs3389412462	694	I>T	No	EVA
rs3389429565	697	N>S	No	EVA
rs3389391521	701	Q>R	No	EVA
rs3389426171	702	N>D	No	EVA

Type	Name	Position	InterPro Accession
domain	Glycoside hydrolase, family 13, N-terminal	76 - 161	IPR004193
domain	Glycosyl hydrolase, family 13, catalytic domain	221 - 568	IPR006047
domain	Alpha-amylase/branching enzyme, C-terminal all beta	603 - 697	IPR006048

		Description
EC Number	2.4.1.18	Hexosyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

Name	Definition
1,4-alpha-glucan branching enzyme activity	Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxyl group in a similar glucan chain.
1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)	Catalysis of the reaction: a glucosylated glycogenin = a glycogen.
carbohydrate binding	Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.
cation binding	Binding to a cation, a charged atom or group of atoms with a net positive charge.
hydrolase activity, hydrolyzing O-glycosyl compounds	Catalysis of the hydrolysis of any O-glycosyl bond.

Name	Definition
carbohydrate metabolic process	The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
glycogen biosynthetic process	The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.
negative regulation of neuron apoptotic process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q6T308	GBE1	1,4-alpha-glucan-branching enzyme	Felis catus (Cat) (Felis silvestris catus)	PR
Q6EAS5	GBE1	1,4-alpha-glucan-branching enzyme	Equus caballus (Horse)	PR
Q04446	GBE1	1,4-alpha-glucan-branching enzyme	Homo sapiens (Human)	PR