Q6T308

PR
Gene name
GBE1
Protein name
1,4-alpha-glucan-branching enzyme
Names
Brancher enzyme, Glycogen-branching enzyme
Species
Felis catus (Cat) (Felis silvestris catus)
KEGG Pathway
fca:493962
EC number
2.4.1.18: Hexosyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-39 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6T308

Entry ID Method Resolution Chain Position Source
AF-Q6T308-F1 Predicted AlphaFoldDB

No variants for Q6T308

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6T308

1 associated diseases with Q6T308

Without disease ID

3 regional properties for Q6T308

Type Name Position InterPro Accession
domain Glycoside hydrolase, family 13, N-terminal 73 - 158 IPR004193
domain Glycosyl hydrolase, family 13, catalytic domain 216 - 565 IPR006047
domain Alpha-amylase/branching enzyme, C-terminal all beta 601 - 694 IPR006048

Functions

Description
EC Number 2.4.1.18 Hexosyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
1,4-alpha-glucan branching enzyme activity Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxyl group in a similar glucan chain.
1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis) Catalysis of the reaction: a glucosylated glycogenin = a glycogen.
cation binding Binding to a cation, a charged atom or group of atoms with a net positive charge.
hydrolase activity, hydrolyzing O-glycosyl compounds Catalysis of the hydrolysis of any O-glycosyl bond.

2 GO annotations of biological process

Name Definition
carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q6EAS5 GBE1 1,4-alpha-glucan-branching enzyme Equus caballus (Horse) PR
Q04446 GBE1 1,4-alpha-glucan-branching enzyme Homo sapiens (Human) PR
Q9D6Y9 Gbe1 1,4-alpha-glucan-branching enzyme Mus musculus (Mouse) PR
10 20 30 40 50 60
MAAPVARGEC SEAALAAALA DVPELARLLE LDPYLKPFAL DFQRRYKKFN ETLNNIGENE
70 80 90 100 110 120
GGIDKFSRGY ESFGVHRCAD GGLYCKEWAP GAEGVFLTGD FNDWNPFSYP YKKLDYGKWE
130 140 150 160 170 180
LYIPPKQNKS QLVPHGSKLK VVIRSKSGEI LYRISPWAKY VTREGENVNY DWTHWDPEHP
190 200 210 220 230 240
YKFKHSRPKK PRGVRIYESH VGISSYEGKI ASYKHFTYNV LPRIKDLGYN CIQMMAIMEH
250 260 270 280 290 300
AYYASFGYQI TSFFAASSRY GTPEELKELV DTAHSMGITV LLDVVHSHAS KNSEDGLNMF
310 320 330 340 350 360
DGTDSCYFHS GPRGNHDLWD SRLFIYSSWE VLRFLLSNIR WWLEEYGFDG FRFDGVTSML
370 380 390 400 410 420
YHHHGMGQAF SGDYHEYFGL QVDEDALIYL MLANHLVHTL YPNSITIAED VSGMPALCSP
430 440 450 460 470 480
ISQGGVGFDY RLAMAIPDKW IQLLKEFKDE DWNMGNIVYT LTNRRYLEKC IAYAESHDQA
490 500 510 520 530 540
LVGDKTLAFW LMDAEMYTNM SVLTPFTPVI DRGIQLHKMI RLITHALGGE GYLNFMGNEF
550 560 570 580 590 600
GHPEWLDFPR KGNNESYHYA RRQFHLTDDD LLRYKFLNNF DRDMNKLEER CGWLSAPQAF
610 620 630 640 650 660
VSEKHEGNKI IAFERAGLVF IFNFHPSKSY TDYRVGTTLP GKFRIVLDTD AAEYGGHQRL
670 680 690
DHSTEFFSQP FKHNERPCSL LVYIPNRVGL ILQNVDMPN