Q6EAS5

PR
Gene name
GBE1
Protein name
1,4-alpha-glucan-branching enzyme
Names
Brancher enzyme, Glycogen-branching enzyme
Species
Equus caballus (Horse)
KEGG Pathway
ecb:100034152
EC number
2.4.1.18: Hexosyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-41 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6EAS5

Entry ID Method Resolution Chain Position Source
AF-Q6EAS5-F1 Predicted AlphaFoldDB

28 variants for Q6EAS5

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3436909385 13 A>T No EVA
rs3437568674 34 Y>* No EVA
rs3430991977 50 S>T No EVA
rs1137941980 75 V>I No EVA
rs3105000775 99 G>E No EVA
rs3091787213 100 D>V No EVA
rs3091763958 101 F>S No EVA
rs3435994602 134 P>L No EVA
rs3445183915 144 R>S No EVA
rs3445136184 144 R>T No EVA
rs3430323256 165 S>G No EVA
rs3437570929 166 G>D No EVA
rs3445203513 210 I>V No EVA
rs3445183931 267 K>Q No EVA
rs3445247844 279 T>I No EVA
rs3444512726 294 E>A No EVA
rs3445029941 325 I>T No EVA
rs3445067852 325 I>V No EVA
rs3445029963 347 G>R No EVA
rs1136548503 399 T>M No EVA
rs3431647519 423 Q>D No EVA
rs3436895160 433 A>Y No EVA
rs3445136582 553 N>R No EVA
rs3445221528 558 H>Y No EVA
rs3445068216 577 L>I No EVA
rs3444632082 584 M>G No EVA
rs3440370512 595 S>N No EVA
rs3445260420 642 K>G No EVA

1 associated diseases with Q6EAS5

Without disease ID

3 regional properties for Q6EAS5

Type Name Position InterPro Accession
domain Glycoside hydrolase, family 13, N-terminal 73 - 158 IPR004193
domain Glycosyl hydrolase, family 13, catalytic domain 219 - 565 IPR006047
domain Alpha-amylase/branching enzyme, C-terminal all beta 601 - 694 IPR006048

Functions

Description
EC Number 2.4.1.18 Hexosyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

4 GO annotations of molecular function

Name Definition
1,4-alpha-glucan branching enzyme activity Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxyl group in a similar glucan chain.
1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis) Catalysis of the reaction: a glucosylated glycogenin = a glycogen.
cation binding Binding to a cation, a charged atom or group of atoms with a net positive charge.
hydrolase activity, hydrolyzing O-glycosyl compounds Catalysis of the hydrolysis of any O-glycosyl bond.

2 GO annotations of biological process

Name Definition
carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q6T308 GBE1 1,4-alpha-glucan-branching enzyme Felis catus (Cat) (Felis silvestris catus) PR
Q04446 GBE1 1,4-alpha-glucan-branching enzyme Homo sapiens (Human) PR
Q9D6Y9 Gbe1 1,4-alpha-glucan-branching enzyme Mus musculus (Mouse) PR
10 20 30 40 50 60
MAAPAARADG SDAALAAALA DVPDLGRLLE VDPYLKPYAP DFQRRYNRFS QTLDNIGKNE
70 80 90 100 110 120
GGIDKFSRGY ESFGVHRCAD GGLYCKEWAP GAEGVFLTGD FNDWNPFSYP YKKLDYGKWD
130 140 150 160 170 180
LYIPPKPNKS LLVPHGSKLK VVIRSKSGEI LYRISPWAKY VVRESGNVNY DWIHWDPEQP
190 200 210 220 230 240
YKFKHSRPKK PRSLRIYESH VGISSHEGKI ASYKHFTCNV LPRIKGLGYN CIQMMAIMEH
250 260 270 280 290 300
AYYASFGYQI TSFFAASSRY GTPEELKELV DTAHSMGITV LLDVVHSHAS KNSEDGLNMF
310 320 330 340 350 360
DGTDSCYFHS GPRGTHDLWD SRLFIYSSWE VLRFLLSNIR WWLEEYGFDG FRFDGVTSML
370 380 390 400 410 420
YHHHGIGASF SGDYHEYFGL QVDEDALTYL MLANHLVHTL YPDSITIAED VSGMPALCSP
430 440 450 460 470 480
ISQGGGGFDY RLAMAIPDKW IQLVKEFKDE DWNMGNIVYT LTNRRHLEKC IAYAESHDQA
490 500 510 520 530 540
LVGDKSLAFW LMDAEMYTNM SVLTPFTPVI DRGIQLHKMI RLITHALGGE GYLNFMGNEF
550 560 570 580 590 600
GHPEWLDFPR KGNNESYHYA RRQFHLTDDD LLRYKFLNNF DRDMNKLEER CGWLSAPQAF
610 620 630 640 650 660
VSEKHEGNKV IAFERAALLF IFNFHPSKSY TNYRVGTTLP GKFKIVLDSD AAEYGGHQRL
670 680 690
DHNTDFFSEP YEHNERPSSL LVYIPSRVAL ILQNVDPPN