AiPD: Autoinhibited Protein Database

Gene name	Efhc2
Protein name	EF-hand domain-containing family member C2
Names
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:74405
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

13-82 (Predicted disordered autoinhibitory region) PR

13-82 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
8I7O	EM	450 A	G5	1-750	PDB
8I7R	EM	650 A	G4/G5/G6	1-750	PDB
8IYJ	EM	350 A	W/X/Y/Z	1-750	PDB
8TO0	EM	770 A	FS/Fg/Fo/Fv	1-750	PDB
AF-Q9D485-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs228707975	39	N>D	No	EVA
rs33784189	46	D>E	No	EVA
rs263423468	89	I>V	No	EVA
rs219004753	121	I>T	No	EVA
rs3389569586	127	Q>K	No	EVA
rs3389555103	129	T>S	No	EVA
rs3409667228	137	P>H	No	EVA
rs1133695489	171	D>A	No	EVA
rs3389566151	177	F>L	No	EVA
rs3389553035	184	K>R	No	EVA
rs3389502245	218	T>I	No	EVA
rs3389553339	223	I>M	No	EVA
rs3389547766	237	D>G	No	EVA
rs3389547806	245	D>H	No	EVA
rs229278316	281	R>W	No	EVA
rs3389557634	287	Y>*	No	EVA
rs3389555061	324	Q>H	No	EVA
rs259079507	324	Q>P	No	EVA
rs218491025	331	D>E	No	EVA
rs3389566174	342	A>T	No	EVA
rs3389547793	343	T>N	No	EVA
rs3389566199	358	E>V	No	EVA
rs3409868752	359	F>Y	No	EVA
rs3409667214	362	T>S	No	EVA
rs3408972229	370	V>I	No	EVA
rs3389520661	398	S>C	No	EVA
rs3409621186	413	P>S	No	EVA
rs244745387	416	K>R	No	EVA
rs3409298051	458	L>P	No	EVA
rs3389557578	474	G>V	No	EVA
rs3389546954	475	N>S	No	EVA
rs3389569569	476	A>D	No	EVA
rs3389557550	478	G>*	No	EVA
rs3389510328	479	M>V	No	EVA
rs219272094	481	L>F	No	EVA
rs33785729	550	Q>R	No	EVA
rs3409627280	551	K>I	No	EVA
rs3389566184	565	V>I	No	EVA
rs234654160	613	D>H	No	EVA
rs3408605373	662	C>Y	No	EVA
rs3407630452	691	E>*	No	EVA
rs3389533730	718	E>*	No	EVA

Type	Name	Position	InterPro Accession
domain	DM10 domain	69 - 182	IPR006602-1
domain	DM10 domain	219 - 368	IPR006602-2
domain	DM10 domain	418 - 537	IPR006602-3

		Description
EC Number
Subcellular Localization	Cytoplasm, cytoskeleton, cilium axoneme
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
axonemal microtubule	A microtubule in the axoneme of a eukaryotic cilium or flagellum; an axoneme contains nine modified doublet microtubules, which may or may not surround a pair of single microtubules.
axoneme	The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.
ciliary basal body	A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport.
mitotic spindle	A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules.

Name	Definition
alpha-tubulin binding	Binding to the microtubule constituent protein alpha-tubulin.

Name	Definition
cellular response to leukemia inhibitory factor	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus.
cilium-dependent cell motility	Cell motility due to the motion of one or more eukaryotic cilia. A eukaryotic cilium is a specialized organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
mitotic cytokinesis	A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
mitotic spindle organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.
regulation of neuron projection development	Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q32TG3	EFHC2	EF-hand domain-containing family member C2	Gallus gallus (Chicken)	PR
Q5JST6	EFHC2	EF-hand domain-containing family member C2	Homo sapiens (Human)	PR
Q32TF8	efhc2	EF-hand domain-containing family member C2	Danio rerio (Zebrafish) (Brachydanio rerio)	PR