Q9D2Y9

PR
Gene name
Elovl7
Protein name
Elongation of very long chain fatty acids protein 7
Names
3-keto acyl-CoA synthase Elovl7, ELOVL fatty acid elongase 7, ELOVL FA elongase 7, Very long chain 3-ketoacyl-CoA synthase 7, Very long chain 3-oxoacyl-CoA synthase 7
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:74559
EC number
2.3.1.199: Transferring groups other than amino-acyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

234-281 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9D2Y9

Entry ID Method Resolution Chain Position Source
AF-Q9D2Y9-F1 Predicted AlphaFoldDB

9 variants for Q9D2Y9

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389318749 34 P>L No EVA
rs3389305142 44 Y>C No EVA
rs3389309751 112 R>M No EVA
rs3404192473 152 T>* No EVA
rs3389276544 160 F>L No EVA
rs3389318724 244 S>R No EVA
rs3389276587 260 A>V No EVA
rs3389318737 261 Y>* No EVA
rs3389297822 280 R>L No EVA

No associated diseases with Q9D2Y9

7 regional properties for Q9D2Y9

Type Name Position InterPro Accession
domain Signal transduction response regulator, receiver domain 612 - 730 IPR001789
domain GAF domain 157 - 315 IPR003018
domain Histidine kinase/HSP90-like ATPase 453 - 585 IPR003594
domain Signal transduction histidine kinase, dimerisation/phosphoacceptor domain 340 - 406 IPR003661
domain Signal transduction histidine kinase-related protein, C-terminal 509 - 523 IPR004358-1
domain Signal transduction histidine kinase-related protein, C-terminal 544 - 562 IPR004358-2
domain Histidine kinase domain 348 - 585 IPR005467

Functions

Description
EC Number 2.3.1.199 Transferring groups other than amino-acyl groups
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
integral component of endoplasmic reticulum membrane The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

3 GO annotations of molecular function

Name Definition
3-oxo-arachidoyl-CoA synthase activity Catalysis of the reaction: stearoyl-CoA(4-) + malonyl-CoA(5-) + H+ <=> 3-oxoicosanoyl-CoA. + carbon dioxide + coenzyme A.
fatty acid elongase activity Catalysis of the reaction: fatty acid (C-16 or longer) + 2-C = fatty acid (C-16 or longer + 2-C).
very-long-chain 3-ketoacyl-CoA synthase activity Catalysis of the reaction: malonyl-CoA + a very-long-chain 2,3,4-saturated fatty acyl CoA = carbon dioxide + coenzyme A + a very-long-chain oxoacyl-CoA.

7 GO annotations of biological process

Name Definition
fatty acid elongation, monounsaturated fatty acid Elongation of a fatty acid chain into which one C-C double bond has been introduced.
fatty acid elongation, polyunsaturated fatty acid Elongation of a fatty acid chain into which two or more C-C double bonds have been introduced.
fatty acid elongation, saturated fatty acid Elongation of a saturated fatty acid chain.
long-chain fatty-acyl-CoA biosynthetic process The chemical reactions and pathways resulting in the formation of a long-chain fatty-acyl-CoA any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more.
sphingolipid biosynthetic process The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
unsaturated fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms.
very long-chain fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid which has a chain length greater than C22.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9BW60 ELOVL1 Elongation of very long chain fatty acids protein 1 Homo sapiens (Human) PR
A1L3X0 ELOVL7 Elongation of very long chain fatty acids protein 7 Homo sapiens (Human) PR
Q9JLJ5 Elovl1 Elongation of very long chain fatty acids protein 1 Mus musculus (Mouse) PR
Q3S8M4 ELOVL4 Elongation of very long chain fatty acids protein 4 Macaca mulatta (Rhesus macaque) PR
10 20 30 40 50 60
MAFSDLTSRT VRFYDNWIKD ADPRVEDYLL MSSPLPQTII LGLYVYFVTS LGPKLMENRK
70 80 90 100 110 120
PFELKKAMIT YNFFIVLFSV YMCYEFVMSG WGTGYSFRCD IVDYSQSPRA MRMVHTCWLY
130 140 150 160 170 180
YFSKFIELLD TIFFVLRKKN SQVTFLHVFH HTIMPWTWWF GVKFAAGGLG TFHAFLNTAV
190 200 210 220 230 240
HVVMYSYYGL CAMGPAYQKY LWWKKHLTSL QLVQFVLVTI HIGQIFFMED CNYQYPVFLY
250 260 270 280
IIMSYGCIFL LLFLHFWYRA YTKGQRLPKT LENGNCKSKR H