AiPD: Autoinhibited Protein Database

A1L3X0

Gene name	ELOVL7
Protein name	Elongation of very long chain fatty acids protein 7
Names	3-keto acyl-CoA synthase ELOVL7, ELOVL fatty acid elongase 7, ELOVL FA elongase 7, Very long chain 3-ketoacyl-CoA synthase 7, Very long chain 3-oxoacyl-CoA synthase 7
Species	Homo sapiens (Human)
KEGG Pathway	hsa:79993
EC number	2.3.1.199: Transferring groups other than amino-acyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

234-281 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

234-281 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for A1L3X0

Entry ID	Method	Resolution	Chain	Position	Source
6Y7F	X-ray	205 A	A/B	1-281	PDB
AF-A1L3X0-F1	Predicted				AlphaFoldDB

211 variants for A1L3X0

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs993148481 CA118806273	2	A>T		No	ClinGen TOPMed gnomAD
rs865939112 CA118806270	2	A>V		No	ClinGen Ensembl
rs1291029526 CA359826624	4	S>N		No	ClinGen TOPMed
rs1386065892 CA359826615	5	D>G		No	ClinGen TOPMed
rs1323148075 CA359826606	6	L>R		No	ClinGen TOPMed gnomAD
rs149077457 CA118806245 COSM1069213	8	S>L	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP NCI-TCGA TOPMed gnomAD
rs1561442414 CA359826592	9	R>K		No	ClinGen Ensembl
rs1382169405 CA359826585	10	T>S		No	ClinGen gnomAD
rs772826135 CA3277552	11	V>M		No	ClinGen ExAC gnomAD
CA359826558 rs1224260058	14	Y>C		No	ClinGen TOPMed
TCGA novel	15	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs748037674 CA3277550	16	N>D		No	ClinGen ExAC TOPMed gnomAD
CA359826529 rs572196960	18	I>F		No	ClinGen gnomAD
CA118806213 rs572196960	18	I>V		No	ClinGen gnomAD
CA3277548 rs144954272	20	D>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs144954272 CA3277549	20	D>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3277525 rs780974146	22	D>G		No	ClinGen ExAC gnomAD
rs1260718376 CA359824776	23	P>S		No	ClinGen gnomAD
rs1010679632 CA118794884	26	E>G		No	ClinGen Ensembl
rs748522826 CA3277523	27	D>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1467154613 CA359824656	28	W>C		No	ClinGen gnomAD
rs1278629969 CA359824671	28	W>G		No	ClinGen gnomAD
CA359824617 rs1345404204	31	M>T		No	ClinGen TOPMed
rs1342063562 CA359824623	31	M>V		No	ClinGen gnomAD
rs1457781822 CA359824598	32	S>C		No	ClinGen TOPMed
CA3277521 rs755383949	33	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1403892836 CA359824572	34	P>L		No	ClinGen gnomAD
CA359824566 rs1458924487	35	L>M		No	ClinGen gnomAD
rs756187498 CA3277518	36	P>S		No	ClinGen ExAC TOPMed gnomAD
CA3277517 rs750549527 COSM3947636	38	T>A	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs767713024 CA3277516	39	I>V		No	ClinGen ExAC gnomAD
CA359824499 rs1241900100	43	F>L		No	ClinGen gnomAD
CA3277512 rs373511341	44	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs140094024 CA3277513	44	Y>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs1243855631 CA359824479	45	V>I		No	ClinGen TOPMed
rs1263404770 CA359824460	46	Y>C		No	ClinGen TOPMed
CA3277510 rs765138464	51	L>F		No	ClinGen ExAC TOPMed gnomAD
rs1315485074 CA359824350	53	P>L		No	ClinGen TOPMed gnomAD
rs376599737 CA118794793	54	K>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs369562030 CA3277508	54	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA359824314 rs147783451	56	M>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA3277505 rs746673276	56	M>T		No	ClinGen ExAC gnomAD
CA3277506 rs147783451	56	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs144190698 COSM1725938 CA3277504	57	E>K	liver [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA3277503 rs769098257	59	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA359824251 COSM1292149 rs1399192362	59	R>H	pancreas haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA359824249 rs1399192362	59	R>L		No	ClinGen TOPMed gnomAD
rs1416299202 CA359824234	61	P>A		No	ClinGen gnomAD
CA3277502 rs749653774	62	F>L		No	ClinGen ExAC gnomAD
rs375834854 CA3277501	63	E>G		No	ClinGen ESP ExAC gnomAD
rs201156536 CA118794728	65	K>N		No	ClinGen Ensembl
CA3277500 rs756637634	66	K>N		No	ClinGen ExAC gnomAD
CA3277499 rs745942972	67	A>T		No	ClinGen ExAC TOPMed gnomAD
rs781250032 CA3277498	67	A>V		No	ClinGen ExAC gnomAD
CA3277497 rs757408055	70	T>A		No	ClinGen ExAC TOPMed gnomAD
CA3277496 COSM1069212 rs199955250	70	T>M	endometrium Variant assessed as Somatic; 4.625e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	70	T>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs752495445 CA3277493	71	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA359824080 rs752495445	71	Y>F		No	ClinGen ExAC TOPMed gnomAD
rs1256736741 CA359824073	72	N>S		No	ClinGen gnomAD
rs765220489 CA3277492	74	F>L		No	ClinGen ExAC gnomAD
TCGA novel	74	F>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	75	I>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs145945715 CA3277491	75	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA359824031 rs1215095198	76	V>A		No	ClinGen TOPMed gnomAD
CA3277490 rs372933045	78	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs925008846 CA118794638	78	F>S		No	ClinGen Ensembl
CA118794628 rs368309905	79	S>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA359823984 rs368309905	79	S>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs368309905 CA3277489	79	S>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA359823980 rs1304030773	80	V>M		No	ClinGen TOPMed gnomAD
CA3277485 rs749650538	82	M>T		No	ClinGen ExAC TOPMed gnomAD
CA118794583 rs1020987671	83	C>F		No	ClinGen Ensembl
CA118794582 rs969911390	84	Y>*		No	ClinGen TOPMed
rs1232906608 CA359823884	85	E>V		No	ClinGen TOPMed
rs1196354786 CA359823455	87	V>A		No	ClinGen TOPMed
rs199575400 CA3277451	87	V>M		No	ClinGen 1000Genomes ExAC gnomAD
CA3277448 rs751200482	88	M>I		No	ClinGen ExAC TOPMed gnomAD
CA3277449 rs761475311	88	M>L		No	ClinGen ExAC gnomAD
CA3277447 rs763772946	89	S>T		No	ClinGen ExAC gnomAD
CA359823417 rs1188949091	90	G>D		No	ClinGen TOPMed
TCGA novel	91	W>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3277446 rs759883343	91	W>R		No	ClinGen ExAC gnomAD
rs777049585 CA3277445	92	G>D		No	ClinGen ExAC gnomAD
rs771365279 CA3277444	93	I>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA359823377 rs1316645129	93	I>R		No	ClinGen gnomAD
rs761104177 CA3277443	94	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs773295195 CA3277442	97	F>I		No	ClinGen ExAC gnomAD
CA3277441 rs200699082	98	R>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs866433834 CA359823319	98	R>P		No	ClinGen TOPMed gnomAD
rs866433834 CA118790945	98	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA3277440 rs748301033	99	C>Y		No	ClinGen ExAC gnomAD
CA3277439 rs779257014	101	I>V		No	ClinGen ExAC gnomAD
CA3277436 rs779998858	106	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs749088345 CA3277437	106	R>W		No	ClinGen ExAC TOPMed gnomAD
CA359823187 rs1384482751	110	A>T		No	ClinGen gnomAD
CA359823180 rs1355905671	110	A>V		No	ClinGen gnomAD
rs758001203 CA3277410	113	M>L		No	ClinGen ExAC gnomAD
rs1584164951 CA359822770	115	R>C		No	ClinGen Ensembl
rs752378124 CA3277409	115	R>H		No	ClinGen ExAC gnomAD
CA359822756 rs1295120998	117	C>F		No	ClinGen gnomAD
CA359822724 rs1363190589	121	Y>*		No	ClinGen gnomAD
CA359822709 rs1341341707	123	S>F		No	ClinGen TOPMed
CA3277407 rs148759721	124	K>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs951412550 CA118790122	126	I>T		No	ClinGen TOPMed
CA3277405 rs767905044	128	L>R		No	ClinGen ExAC gnomAD
rs750860207 CA359822675	128	L>V		No	ClinGen ExAC gnomAD
rs762385054 CA3277404	130	D>H		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	131	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs774514081 CA3277403	131	T>M	Variant assessed as Somatic; 4.621e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs781629199	132	I>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA118788606 rs887878720	133	F>C		No	ClinGen TOPMed gnomAD
CA3277387 rs757654842	134	F>L		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	135	V>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM3410336 rs200379193 CA3277386	137	R>C	central_nervous_system [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA3277385 rs764734594	137	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs764734594 CA118788582	137	R>L		No	ClinGen ExAC TOPMed gnomAD
CA3277384 rs763099478	138	K>R		No	ClinGen ExAC gnomAD
CA359822282 rs1231864854	140	N>D		No	ClinGen gnomAD
CA3277382 rs765312108	140	N>T		No	ClinGen ExAC gnomAD
rs1584160001 CA359822233	142	Q>*		No	ClinGen Ensembl
CA3277381 rs759820418	143	V>M		No	ClinGen ExAC TOPMed gnomAD
CA118788540 rs975977103	146	L>V		No	ClinGen Ensembl
CA3277379 rs375929224	147	H>R		No	ClinGen ESP ExAC gnomAD
rs1414693188 CA359822114	149	F>C		No	ClinGen TOPMed
rs1184102476 CA359822122	149	F>L		No	ClinGen TOPMed
rs1409386996 CA359822109	149	F>L		No	ClinGen TOPMed
CA359822101 rs1181616389	150	H>Y		No	ClinGen gnomAD
rs760504279 CA3277378	151	H>R		No	ClinGen ExAC gnomAD
CA3277377 rs773112795	153	I>V		No	ClinGen ExAC gnomAD
TCGA novel	154	M>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3277376 rs200377514	155	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA118788523 rs866345231	155	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs768134267 CA3277373	158	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA
CA359821942 rs1308465090	159	W>*		No	ClinGen TOPMed
rs1584159719 CA359821949	159	W>R		No	ClinGen Ensembl
rs1351059500 CA359821932	160	F>L		No	ClinGen gnomAD
rs748991590 CA3277372	161	G>R		No	ClinGen ExAC TOPMed gnomAD
rs781370319 CA3277371	162	V>I		No	ClinGen ExAC gnomAD
TCGA novel	164	F>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3277370 rs757660472	165	A>V		No	ClinGen ExAC TOPMed gnomAD
CA359821898 rs1453406570	166	A>S		No	ClinGen gnomAD
rs752016580 CA3277369	166	A>V		No	ClinGen ExAC gnomAD
CA3277350 rs758928464 COSM482935	172	F>L	kidney [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs375469282 CA3277349	174	A>P		No	ClinGen ESP ExAC TOPMed
CA3277348 rs779332363	175	L>F		No	ClinGen ExAC TOPMed gnomAD
rs766584906 CA3277344	180	V>I		No	ClinGen ExAC gnomAD
rs372397313 CA3277342	181	H>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs372397313 CA3277343	181	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA359821187 rs1319820556	182	V>I		No	ClinGen gnomAD
rs761698111 CA3277340	188	Y>C		No	ClinGen ExAC gnomAD
rs1294325992 CA359821143	188	Y>H		No	ClinGen TOPMed
rs1277724183 CA359821133	189	G>A		No	ClinGen gnomAD
rs774313366 CA3277338	190	L>I		No	ClinGen ExAC gnomAD
CA3277337 rs763982943	191	S>Y		No	ClinGen ExAC gnomAD
rs1348627025 CA359821099	195	P>S		No	ClinGen TOPMed gnomAD
TCGA novel	197	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1410000088 CA359821048	202	W>R		No	ClinGen gnomAD
TCGA novel	203	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	205	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs773675782 CA3277332	206	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs1452891362 CA359820981	211	Q>K		No	ClinGen Ensembl
rs748514510 CA3277330	212	L>F		No	ClinGen ExAC gnomAD
CA359820859 rs1462731009	213	V>F		No	ClinGen TOPMed gnomAD
CA359820854 rs1423569684	213	V>G		No	ClinGen TOPMed
rs1365878846 CA359820847	214	Q>H		No	ClinGen gnomAD
CA359820850 rs1186111107	214	Q>R		No	ClinGen TOPMed
rs1263947601 CA359820842	215	F>S		No	ClinGen gnomAD
CA359820827 rs1232815845	217	I>T		No	ClinGen gnomAD
CA359820818 rs1425385292	219	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1400067550 CA359820793	222	I>R		No	ClinGen TOPMed gnomAD
CA3277312 rs770769866	222	I>V		No	ClinGen ExAC gnomAD
CA359820779 rs748545912	224	Q>P		No	ClinGen ExAC TOPMed gnomAD
rs748545912 CA3277311	224	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA3277310 rs774587046	227	F>L		No	ClinGen ExAC gnomAD
CA359820751 rs1298925920	228	M>L		No	ClinGen TOPMed
TCGA novel	228	M>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA118782959 rs979695222	230	D>E		No	ClinGen TOPMed
CA359820717 rs546154166	230	D>G		No	ClinGen gnomAD
rs1032193221 CA118782962	230	D>N		No	ClinGen TOPMed gnomAD
CA118782960 rs546154166	230	D>V		No	ClinGen gnomAD
CA3277309 rs769151593	233	Y>*		No	ClinGen ExAC gnomAD
CA359820675 rs1346669495	233	Y>D		No	ClinGen gnomAD
rs1384823154 CA359820646	235	F>L		No	ClinGen TOPMed
CA3277307 rs114998585 COSM1069209	239	A>V	endometrium [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs1584138045 CA359820551	241	I>M		No	ClinGen Ensembl
CA359820547 rs1206231495	242	I>V		No	ClinGen TOPMed
rs745992984 CA3277305	243	M>I		No	ClinGen ExAC TOPMed gnomAD
CA359820522 rs1243839419	243	M>T		No	ClinGen TOPMed gnomAD
CA359820533 rs1446451843	243	M>V		No	ClinGen gnomAD
CA3277304 rs781379671	246	S>G		No	ClinGen ExAC gnomAD
rs1262764501 CA359820469	247	F>S		No	ClinGen gnomAD
rs751300316 CA3277302	248	M>T		No	ClinGen ExAC gnomAD
CA3277303 rs757486640	248	M>V		No	ClinGen ExAC gnomAD
rs1584137900 CA359820417	252	L>P		No	ClinGen Ensembl
CA118782896 rs867188493	255	H>Y		No	ClinGen Ensembl
rs763943204 CA3277301	257	W>*		No	ClinGen ExAC TOPMed gnomAD
CA3277300 rs116939630	259	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA3277299 rs765315081	259	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA3277298 rs765315081	259	R>P		No	ClinGen ExAC TOPMed gnomAD
rs753469558 CA3277296	262	T>I		No	ClinGen ExAC gnomAD
CA3277294 rs374457003	264	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA3277293 rs760262528	265	Q>H		No	ClinGen ExAC gnomAD
CA3277292 rs774731618	266	R>G		No	ClinGen ExAC TOPMed gnomAD
rs1422155845 CA359820292	271	V>A		No	ClinGen gnomAD
CA3277287 rs141936060	275	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA3277286 rs570407523	277	K>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA3277285 rs138772725	278	N>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs1341070373 CA359820222	281	N>Y		No	ClinGen gnomAD
rs1265423967	282	N>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs771125083 CA3277284	282	N>R		No	ClinGen ExAC gnomAD

No associated diseases with A1L3X0

1 regional properties for A1L3X0

Type	Name	Position	InterPro Accession
conserved_site	ELO family, conserved site	143 - 151	IPR030457

Functions

		Description
EC Number	2.3.1.199	Transferring groups other than amino-acyl groups
Subcellular Localization	Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.
integral component of endoplasmic reticulum membrane	The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

3 GO annotations of molecular function

Name	Definition
3-oxo-arachidoyl-CoA synthase activity	Catalysis of the reaction: stearoyl-CoA(4-) + malonyl-CoA(5-) + H+ <=> 3-oxoicosanoyl-CoA. + carbon dioxide + coenzyme A.
fatty acid elongase activity	Catalysis of the reaction: fatty acid (C-16 or longer) + 2-C = fatty acid (C-16 or longer + 2-C).
very-long-chain 3-ketoacyl-CoA synthase activity	Catalysis of the reaction: malonyl-CoA + a very-long-chain 2,3,4-saturated fatty acyl CoA = carbon dioxide + coenzyme A + a very-long-chain oxoacyl-CoA.

7 GO annotations of biological process

Name	Definition
fatty acid elongation, monounsaturated fatty acid	Elongation of a fatty acid chain into which one C-C double bond has been introduced.
fatty acid elongation, polyunsaturated fatty acid	Elongation of a fatty acid chain into which two or more C-C double bonds have been introduced.
fatty acid elongation, saturated fatty acid	Elongation of a saturated fatty acid chain.
long-chain fatty-acyl-CoA biosynthetic process	The chemical reactions and pathways resulting in the formation of a long-chain fatty-acyl-CoA any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more.
sphingolipid biosynthetic process	The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
unsaturated fatty acid biosynthetic process	The chemical reactions and pathways resulting in the formation of an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms.
very long-chain fatty acid biosynthetic process	The chemical reactions and pathways resulting in the formation of a fatty acid which has a chain length greater than C22.

4 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9BW60	ELOVL1	Elongation of very long chain fatty acids protein 1	Homo sapiens (Human)	PR
Q9JLJ5	Elovl1	Elongation of very long chain fatty acids protein 1	Mus musculus (Mouse)	PR
Q9D2Y9	Elovl7	Elongation of very long chain fatty acids protein 7	Mus musculus (Mouse)	PR
Q3S8M4	ELOVL4	Elongation of very long chain fatty acids protein 4	Macaca mulatta (Rhesus macaque)	PR

10	20	30	40	50	60
MAFSDLTSRT	VHLYDNWIKD	ADPRVEDWLL	MSSPLPQTIL	LGFYVYFVTS	LGPKLMENRK
70	80	90	100	110	120
PFELKKAMIT	YNFFIVLFSV	YMCYEFVMSG	WGIGYSFRCD	IVDYSRSPTA	LRMARTCWLY
130	140	150	160	170	180
YFSKFIELLD	TIFFVLRKKN	SQVTFLHVFH	HTIMPWTWWF	GVKFAAGGLG	TFHALLNTAV
190	200	210	220	230	240
HVVMYSYYGL	SALGPAYQKY	LWWKKYLTSL	QLVQFVIVAI	HISQFFFMED	CKYQFPVFAC
250	260	270	280
IIMSYSFMFL	LLFLHFWYRA	YTKGQRLPKT	VKNGTCKNKD	N