Q9CZX7

PR
Gene name
Pip4p2 (Tmem55a)
Protein name
Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase
Names
Type 2 PtdIns-4,5-P2 4-Ptase, PtdIns-4,5-P2 4-Ptase II, Transmembrane protein 55A
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:72519
EC number
3.1.3.78: Phosphoric monoester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-80 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9CZX7

Entry ID Method Resolution Chain Position Source
AF-Q9CZX7-F1 Predicted AlphaFoldDB

11 variants for Q9CZX7

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3412028286 86 P>S No EVA
rs3388667177 102 N>T No EVA
rs3388663141 116 C>Y No EVA
rs3412829884 175 P>L No EVA
rs3388674356 179 K>N No EVA
rs3388678586 192 C>Y No EVA
rs3388668769 210 T>A No EVA
rs3388660113 212 G>D No EVA
rs3388671317 216 F>S No EVA
rs3388671239 238 L>R No EVA
rs3388668764 251 Y>C No EVA

No associated diseases with Q9CZX7

No regional properties for Q9CZX7

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q9CZX7

Functions

Description
EC Number 3.1.3.78 Phosphoric monoester hydrolases
Subcellular Localization
  • Late endosome membrane ; Multi-pass membrane protein
  • Lysosome membrane ; Multi-pass membrane protein
  • Cell membrane ; Multi-pass membrane protein
  • Cytoplasmic vesicle, phagosome membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
late endosome membrane The lipid bilayer surrounding a late endosome.
lysosomal membrane The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
phagocytic vesicle membrane The lipid bilayer surrounding a phagocytic vesicle.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity Catalysis of the reaction: 1-phosphatidyl-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate.

2 GO annotations of biological process

Name Definition
negative regulation of phagocytosis Any process that stops, prevents, or reduces the frequency, rate or extent of phagocytosis.
phosphatidylinositol dephosphorylation The process of removing one or more phosphate groups from a phosphatidylinositol.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3SZ48 PIP4P2 Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase Bos taurus (Bovine) PR
Q8N4L2 PIP4P2 Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase Homo sapiens (Human) PR
Q4V888 Pip4p2 Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase Rattus norvegicus (Rat) PR
Q6DIE4 pip4p2 Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MAADGVDERS PLLSASHSGN VTPTAPPYLQ ESSPRAELPP PYTAIASPGT SGIPVINCRV
70 80 90 100 110 120
CQSLINLDGK LHQHVVKCTV CNEATPIKTP PTGKKYVRCP CNCLLICKDT SRRIGCPRPN
130 140 150 160 170 180
CRRIINLGPV MLISEEQPAQ PALPIQPEGT RVVCGHCGNT FLWMELRFNT LAKCPHCKKI
190 200 210 220 230 240
SSVGSALPRR RCCAYVTIGM ICIFIAVGLT VGTQDFSRRF HATYVSWAIA YLLGLICLIR
250
ACYWGAIRVS YPEHGFA