Q4V888

PR
Gene name
Pip4p2 (Tmem55a)
Protein name
Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase
Names
Type 2 PtdIns-4,5-P2 4-Ptase, PtdIns-4,5-P2 4-Ptase II, Transmembrane protein 55A
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:362490
EC number
3.1.3.78: Phosphoric monoester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-81 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q4V888

Entry ID Method Resolution Chain Position Source
AF-Q4V888-F1 Predicted AlphaFoldDB

1 variants for Q4V888

Variant ID(s) Position Change Description Diseaes Association Provenance
rs8165217 6 V>M No EVA

No associated diseases with Q4V888

No regional properties for Q4V888

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q4V888

Functions

Description
EC Number 3.1.3.78 Phosphoric monoester hydrolases
Subcellular Localization
  • Late endosome membrane ; Multi-pass membrane protein
  • Lysosome membrane ; Multi-pass membrane protein
  • Cytoplasmic vesicle, phagosome membrane ; Multi-pass membrane protein
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
late endosome membrane The lipid bilayer surrounding a late endosome.
lysosomal membrane The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
phagocytic vesicle membrane The lipid bilayer surrounding a phagocytic vesicle.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity Catalysis of the reaction: 1-phosphatidyl-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate.

2 GO annotations of biological process

Name Definition
negative regulation of phagocytosis Any process that stops, prevents, or reduces the frequency, rate or extent of phagocytosis.
phosphatidylinositol dephosphorylation The process of removing one or more phosphate groups from a phosphatidylinositol.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3SZ48 PIP4P2 Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase Bos taurus (Bovine) PR
Q8N4L2 PIP4P2 Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase Homo sapiens (Human) PR
Q9CZX7 Pip4p2 Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase Mus musculus (Mouse) PR
Q6DIE4 pip4p2 Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MAADGVDERS PLLSASHSGN VTPTAPPYLQ ESSPRAELPP PYTAIASPGT SGIPVINCRV
70 80 90 100 110 120
CQSLINLDGK LHQHVVKCTV CNEATPIKTP PTGKKYVRCP CNCLLICKDT SRRIGCPRPN
130 140 150 160 170 180
CRRIINLGPI MLISEEQPAQ PALPVQPEGT RVVCGHCGNT FLWMELRFNT LAKCPHCKKI
190 200 210 220 230 240
SSVGSALPRR RCCAYVTIGM ICIFIGVGLT VGTQDFSRRF HATYVSWAIA YLLGLICLIR
250
ACYWGAIRVS YPEHGFA