Q3SZ48

PR
Gene name
PIP4P2
Protein name
Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase
Names
Type 2 PtdIns-4,5-P2 4-Ptase, PtdIns-4,5-P2 4-Ptase II, Transmembrane protein 55A
Species
Bos taurus (Bovine)
KEGG Pathway
bta:616641
EC number
3.1.3.78: Phosphoric monoester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-76 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3SZ48

Entry ID Method Resolution Chain Position Source
AF-Q3SZ48-F1 Predicted AlphaFoldDB

8 variants for Q3SZ48

Variant ID(s) Position Change Description Diseaes Association Provenance
rs446534760 103 C>S No EVA
rs471926661 117 P>Q No EVA
rs462122149 165 E>D No EVA
rs444770575 169 N>D No EVA
rs463279828 170 T>P No EVA
rs478389802 171 L>R No EVA
rs460231988 179 K>* No EVA
rs439604707 223 T>P No EVA

No associated diseases with Q3SZ48

4 regional properties for Q3SZ48

Type Name Position InterPro Accession
domain Peptidase M16, C-terminal 245 - 427 IPR007863-1
domain Peptidase M16, C-terminal 774 - 956 IPR007863-2
domain Peptidase M16, N-terminal 96 - 177 IPR011765
domain Peptidase M16C associated 504 - 752 IPR013578

Functions

Description
EC Number 3.1.3.78 Phosphoric monoester hydrolases
Subcellular Localization
  • Late endosome membrane ; Multi-pass membrane protein
  • Lysosome membrane ; Multi-pass membrane protein
  • Cytoplasmic vesicle, phagosome membrane ; Multi-pass membrane protein
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
late endosome membrane The lipid bilayer surrounding a late endosome.
lysosomal membrane The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
phagocytic vesicle membrane The lipid bilayer surrounding a phagocytic vesicle.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity Catalysis of the reaction: 1-phosphatidyl-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate.

2 GO annotations of biological process

Name Definition
negative regulation of phagocytosis Any process that stops, prevents, or reduces the frequency, rate or extent of phagocytosis.
phosphatidylinositol dephosphorylation The process of removing one or more phosphate groups from a phosphatidylinositol.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8N4L2 PIP4P2 Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase Homo sapiens (Human) PR
Q9CZX7 Pip4p2 Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase Mus musculus (Mouse) PR
Q4V888 Pip4p2 Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase Rattus norvegicus (Rat) PR
Q6DIE4 pip4p2 Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MAADGVDERS PLLSASHSGS VTPTAPPYLQ DSSPRAELPP PYTAIVSPDA SGIPVINCRV
70 80 90 100 110 120
CQSLINLDGK LHQHVVKCTV CNEATPIKNP PAGKKYVRCP CNCLLICKDT SRRIGCPRPN
130 140 150 160 170 180
CRRIINLGPV MLVSEEQPAQ PALPVQPEGT RVVCGHCGNT FLWMELRFNT LAKCPHCKKI
190 200 210 220 230 240
SSVGSALPRR RCCAYITIGM MCIFIGIGLT VGTQDFARRF HATYVSWAIA YLLGLVCLIR
250
ACYWGAIRVS YPEHSFA