Q9CZC8
Gene name |
Scrn1 (Kiaa0193) |
Protein name |
Secernin-1 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:69938 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9CZC8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9CZC8-F1 | Predicted | AlphaFoldDB |
23 variants for Q9CZC8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388809469 | 21 | L>P | No | EVA | |
| rs3388824662 | 75 | W>C | No | EVA | |
| rs3388826352 | 76 | L>F | No | EVA | |
| rs3388836536 | 114 | R>K | No | EVA | |
| rs3388820814 | 146 | D>N | No | EVA | |
| rs3388820816 | 168 | L>M | No | EVA | |
| rs3388826926 | 168 | L>RDG* | No | EVA | |
| rs3388831383 | 188 | C>R | No | EVA | |
| rs219749750 | 199 | E>G | No | EVA | |
| rs238757514 | 232 | R>H | No | EVA | |
| rs3396955945 | 234 | D>A | No | EVA | |
| rs3396620635 | 236 | C>* | No | EVA | |
| rs3396836595 | 236 | C>S | No | EVA | |
| rs3396004804 | 236 | C>S | No | EVA | |
| rs3396371497 | 238 | G>V | No | EVA | |
| rs3388797672 | 244 | K>R | No | EVA | |
| rs3388837813 | 247 | E>* | No | EVA | |
| rs3388832928 | 255 | I>T | No | EVA | |
| rs3388819993 | 264 | G>E* | No | EVA | |
| rs3388824711 | 318 | P>S | No | EVA | |
| rs3388818289 | 363 | E>* | No | EVA | |
| rs3396835530 | 385 | E>A | No | EVA | |
| rs3388818292 | 400 | D>V | No | EVA |
No associated diseases with Q9CZC8
No regional properties for Q9CZC8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q9CZC8 | |||
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nuclear membrane | Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| cysteine-type exopeptidase activity | Catalysis of the hydrolysis of C- or N-terminal peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. |
| dipeptidase activity | Catalysis of the hydrolysis of a dipeptide. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| exocytosis | A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell. |
| proteolysis | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSGAPPSYSF | VALPPRAKDG | LVVFGKNSAR | PRDEVQEVVY | FPAVDHDAES | KVECTYISID |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QVPRTHAIVI | SRPAWLWGAE | MGANEHGVCI | ANEAINAREP | AAETEALLGM | DLVRLGLERG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TTAKEALDII | VSLLDEHGQG | GNYYEDAHSC | HSFQSAYLLV | DRDEAWVLET | VGKYWAAERI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TEGVRCICNH | LSLATKLDEE | HPELRTYAQS | QGWWTGDDEF | NFAQVFSPAD | DRLDCCAGQD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SLEKQEESIT | VQTMINILRD | KASGVCIDSE | SFLTTASIVS | VLPQNRSSPC | IHYFTGTPDP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SRSIFKPFIF | VDDVKLVPKA | QSPCFGDDDP | AKKEPRFQEK | PDRRHELYKA | HEWARAVIES |
| 370 | 380 | 390 | 400 | 410 | |
| DEEQGRTLRK | TMLELEKQGL | EAMDEILSSP | EPPDPAEVGD | LFYDCVDTEM | KFFK |