Q9CYH6

PR
Gene name
Rrs1 (Rrr, MNCb-2643)
Protein name
Ribosome biogenesis regulatory protein homolog
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:59014
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

147-234 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9CYH6

Entry ID Method Resolution Chain Position Source
AF-Q9CYH6-F1 Predicted AlphaFoldDB

82 variants for Q9CYH6

Variant ID(s) Position Change Description Diseaes Association Provenance
rs1135205612 6 V>M No EVA
rs219787222 16 E>A No EVA
rs236795984 20 K>M No EVA
rs221521688 23 R>C No EVA
rs221521688 23 R>G No EVA
rs221521688 23 R>S No EVA
rs1134390760 25 T>M No EVA
rs1133122263 33 E>V No EVA
rs240495249 42 S>* No EVA
rs240495249 42 S>L No EVA
rs1132797452 44 R>H No EVA
rs1133390479 47 P>L No EVA
rs1132581608 48 T>I No EVA
rs1134206340 49 V>M No EVA
rs1134894200 51 R>C No EVA
rs1135024078 53 A>P No EVA
rs1133127619 54 G>R No EVA
rs1133411620 54 G>V No EVA
rs222654214 57 P>L No EVA
rs1132601097 78 R>Q No EVA
rs1132949835 80 P>Q No EVA
rs1132949835 80 P>R No EVA
rs1132155752 81 T>I No EVA
rs1134210499 81 T>S No EVA
rs1134247736 82 E>K No EVA
rs1133132277 93 P>Q No EVA
rs584997038 97 T>S No EVA
rs578957788 101 R>H No EVA
rs1132163816 106 P>H No EVA
rs261429444 109 R>W No EVA
rs1134418048 111 L>F No EVA
rs1133806391 113 R>C No EVA
rs1133806391 113 R>S No EVA
rs1133007456 115 Q>P No EVA
rs1135227550 116 Q>K No EVA
rs231364652 118 A>P No EVA
rs231364652 118 A>T No EVA
rs250920251 118 A>V No EVA
rs258180033 124 R>H No EVA
rs258180033 124 R>L No EVA
rs581847550 133 W>L No EVA
rs226870665 134 D>E No EVA
rs13467798 135 E>V No EVA
rs247526500 143 R>H No EVA
rs247526500 143 R>L No EVA
rs247526500 143 R>P No EVA
rs1132858731 151 D>N No EVA
rs13459050 154 K>N No EVA
rs1133412342 157 L>V No EVA
rs1132180646 159 E>Q No EVA
rs1133829891 164 A>S No EVA
rs1132819588 165 D>N No EVA
rs582196967 182 V>M No EVA
rs1133438750 189 R>C No EVA
rs1133977957 194 A>P No EVA
rs108043093 195 R>H No EVA
rs235816204 200 Q>R No EVA
rs580268787 210 T>N No EVA
rs108170653 218 L>M No EVA
rs107851109 230 A>T No EVA
rs108911944 231 S>* No EVA
rs108911944 231 S>L No EVA
rs580154643 234 R>C No EVA
rs580154643 234 R>S No EVA
rs1132468305 246 R>Q No EVA
rs1133303610 246 R>W No EVA
rs3388456981 247 G>A No EVA
rs3388457399 247 G>S No EVA
rs108783580 249 G>C No EVA
rs108783580 249 G>S No EVA
rs1133676311 264 E>K No EVA
rs1133638445 272 L>H No EVA
rs1133429939 273 R>L No EVA
rs1132044243 281 R>Q No EVA
rs1134491772 285 T>M No EVA
rs1132190653 310 G>D No EVA
rs108285203 316 R>W No EVA
rs1135346783 319 P>S No EVA
rs108419698 337 G>D No EVA
rs13467801 343 H>N No EVA
rs13467799 345 W>R No EVA
rs108094096 350 A>G No EVA

No associated diseases with Q9CYH6

No regional properties for Q9CYH6

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q9CYH6

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
condensed nuclear chromosome A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome.
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
preribosome, large subunit precursor A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit.

1 GO annotations of molecular function

Name Definition
5S rRNA binding Binding to a 5S ribosomal RNA, the smallest RNA constituent of a ribosome.

8 GO annotations of biological process

Name Definition
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.
hematopoietic progenitor cell differentiation The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells.
mitotic metaphase plate congression The cell cycle process in which chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the mitotic spindle, during mitosis.
protein localization to nucleolus A process in which a protein is transported to, or maintained in, a location within a nucleolus.
regulation of signal transduction by p53 class mediator Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator.
ribosomal large subunit assembly The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit.
ribosomal large subunit biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis.
ribosomal large subunit export from nucleus The directed movement of a ribosomal large subunit from the nucleus into the cytoplasm.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2KIH4 RRS1 Ribosome biogenesis regulatory protein homolog Bos taurus (Bovine) PR
Q15050 RRS1 Ribosome biogenesis regulatory protein homolog Homo sapiens (Human) PR
A1A5P2 Rrs1 Ribosome biogenesis regulatory protein homolog Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MEGQRVEELL AKAEQEEAEK LQRITVHKEL ELEFDLGNLL ASDRNPPTVL RQAGPSPEAE
70 80 90 100 110 120
LRALARDNTQ LLINQLWRLP TERVEEAVVA RLPEPATRLP REKPLPRPRP LTRWQQFARL
130 140 150 160 170 180
KGIRPKKKTN LVWDEASGQW RRRWGYKRAR DDTKEWLIEV PGSADPMEDQ FAKRTQAKKE
190 200 210 220 230 240
RVAKNELNRL RNLARAHKMQ MPSSAGLHPT GHQSKEELGR AMQVAKVSTA SVGRFQERLP
250 260 270 280 290 300
KEKAPRGSGK KRKFQPLFGD FAAEKKNQLE LLRVMNSKKP RLDVTRATNK QMREEDQEEA
310 320 330 340 350 360
AKRRKMSQKG KRKGGRQGPS GKRKGGPPGQ GEKRKGGLGS KKHSWPSALA GKKKGVPPQG
GKRRK