A1A5P2

PR
Gene name
Rrs1
Protein name
Ribosome biogenesis regulatory protein homolog
Names
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:297784
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-49 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A1A5P2

Entry ID Method Resolution Chain Position Source
AF-A1A5P2-F1 Predicted AlphaFoldDB

1 variants for A1A5P2

Variant ID(s) Position Change Description Diseaes Association Provenance
rs197068687 322 R>K No EVA

No associated diseases with A1A5P2

No regional properties for A1A5P2

Type Name Position InterPro Accession
No domain, repeats, and functional sites for A1A5P2

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
condensed nuclear chromosome A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome.
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
preribosome, large subunit precursor A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit.

1 GO annotations of molecular function

Name Definition
5S rRNA binding Binding to a 5S ribosomal RNA, the smallest RNA constituent of a ribosome.

8 GO annotations of biological process

Name Definition
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.
hematopoietic progenitor cell differentiation The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells.
mitotic metaphase plate congression The cell cycle process in which chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the mitotic spindle, during mitosis.
protein localization to nucleolus A process in which a protein is transported to, or maintained in, a location within a nucleolus.
regulation of signal transduction by p53 class mediator Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator.
ribosomal large subunit assembly The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit.
ribosomal large subunit biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis.
ribosomal large subunit export from nucleus The directed movement of a ribosomal large subunit from the nucleus into the cytoplasm.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2KIH4 RRS1 Ribosome biogenesis regulatory protein homolog Bos taurus (Bovine) PR
Q15050 RRS1 Ribosome biogenesis regulatory protein homolog Homo sapiens (Human) PR
Q9CYH6 Rrs1 Ribosome biogenesis regulatory protein homolog Mus musculus (Mouse) PR
10 20 30 40 50 60
MEGQSVEELL AKAKQEEAEK LQRITVHKEL ELEFDLGNLL ASDRNPPTVL RQAGPSPEAE
70 80 90 100 110 120
LRALARDNTQ LLVNQLWQLP TERVEEAVVA RLPEPATRLP REKPLPRPRP LTRWQQFARL
130 140 150 160 170 180
KGIRPKKKTN LVWDEVSGQW RRRWGYKRAR DDTKEWLIEV PGSADPMEDQ FAKRIRAKKE
190 200 210 220 230 240
RVAKNELNRL RNLARAHKMQ MPSSAGLHPT GHQSKEELGR AMQVAKVSTA SVGRFQERLP
250 260 270 280 290 300
KEKAPRGSGK KRKFQPLFGD FAAEKKNQLE LLRVMNSKKP QLDVTRATNK QMREEDQEEA
310 320 330 340 350 360
AKRRKMSQKG KKKGGRQGPS GRRKGGPPSQ GEKRKGVLGG KKHSRPPALG GKKKGVPHHG
GKRRK