Q2KIH4
Gene name |
RRS1 |
Protein name |
Ribosome biogenesis regulatory protein homolog |
Names |
|
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:510956 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q2KIH4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q2KIH4-F1 | Predicted | AlphaFoldDB |
No variants for Q2KIH4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q2KIH4 | |||||
No associated diseases with Q2KIH4
No regional properties for Q2KIH4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q2KIH4 | |||
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| condensed nuclear chromosome | A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| preribosome, large subunit precursor | A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| 5S rRNA binding | Binding to a 5S ribosomal RNA, the smallest RNA constituent of a ribosome. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. |
| mitotic metaphase plate congression | The cell cycle process in which chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the mitotic spindle, during mitosis. |
| protein localization to nucleolus | A process in which a protein is transported to, or maintained in, a location within a nucleolus. |
| regulation of signal transduction by p53 class mediator | Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator. |
| ribosomal large subunit assembly | The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit. |
| ribosomal large subunit biogenesis | A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis. |
| ribosomal large subunit export from nucleus | The directed movement of a ribosomal large subunit from the nucleus into the cytoplasm. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q15050 | RRS1 | Ribosome biogenesis regulatory protein homolog | Homo sapiens (Human) | PR |
| Q9CYH6 | Rrs1 | Ribosome biogenesis regulatory protein homolog | Mus musculus (Mouse) | PR |
| A1A5P2 | Rrs1 | Ribosome biogenesis regulatory protein homolog | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEGQSVEELL | AKAERDEAEK | LQRITVLKEL | ELEFDLGNLL | ASDRNPPTGL | RHAGPTQEAE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LRALARDNTQ | LLINQLWQLP | TERVEEALVA | RLPEPSTRLP | REKPVPRPRP | LTRWQQFARL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KGIRPKKKTN | LVWDEVSGRW | RRRWGYQRAR | DDTKEWLIEV | PGNADPMEDQ | FAKRIQAKKE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RVAKNELNRL | RNLARAHKMQ | LPSAAGMHPT | GHQSKEELGR | AMQVAKVSTA | SVGRFQERLP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KEKAPRGSGK | KRKFQPLFGD | FAAERKSQLE | MLRVMNSKKP | QMDITRATNK | QMREEDQEEA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AKRRKMSQKG | KRKGGRQGPG | SKRKGGTPSQ | GGKRKGGLGG | KMNSGPPGLS | GKRKGGQHQG |
| GKRRK |