Q9C713
PR
Gene name |
At1g66530 (F28G11.14) |
Protein name |
Arginine--tRNA ligase, cytoplasmic |
Names |
Arginyl-tRNA synthetase, ArgRS |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G66530 |
EC number |
6.1.1.19: Ligases forming aminoacyl-tRNA and related compounds |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9C713
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9C713-F1 | Predicted | AlphaFoldDB |
64 variants for Q9C713
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH01483534 | 7 | S>N | No | 1000Genomes | |
| tmp_1_24822156_C_T | 12 | G>R | No | 1000Genomes | |
| tmp_1_24822138_G_C | 18 | L>V | No | 1000Genomes | |
| ENSVATH13747588 | 34 | P>R | No | 1000Genomes | |
| tmp_1_24821951_C_A | 55 | G>* | No | 1000Genomes | |
| ENSVATH13747585 | 61 | K>R | No | 1000Genomes | |
| tmp_1_24821924_C_A,T | 64 | G>C | No | 1000Genomes | |
| tmp_1_24821924_C_A,T | 64 | G>S | No | 1000Genomes | |
| ENSVATH13747583 | 74 | G>R | No | 1000Genomes | |
| tmp_1_24821791_C_G | 79 | Q>H | No | 1000Genomes | |
| tmp_1_24821773_C_G | 85 | E>D | No | 1000Genomes | |
| ENSVATH01483527 | 91 | S>A | No | 1000Genomes | |
| ENSVATH13747574 | 107 | M>I | No | 1000Genomes | |
| ENSVATH05081835 | 109 | K>N | No | 1000Genomes | |
| ENSVATH13747569 | 110 | S>N | No | 1000Genomes | |
| tmp_1_24821626_T_C | 111 | I>V | No | 1000Genomes | |
| ENSVATH00126840 | 115 | L>V | No | 1000Genomes | |
| tmp_1_24821610_A_G | 116 | V>A | No | 1000Genomes | |
| ENSVATH05081832 | 116 | V>I | No | 1000Genomes | |
| ENSVATH05081829 | 129 | K>T | No | 1000Genomes | |
| tmp_1_24821500_T_C | 153 | I>V | No | 1000Genomes | |
| ENSVATH00126839 | 164 | Y>F | No | 1000Genomes | |
| tmp_1_24821065_A_C | 224 | F>L | No | 1000Genomes | |
| ENSVATH01483508 | 237 | G>D | No | 1000Genomes | |
| ENSVATH01483509 | 237 | G>S | No | 1000Genomes | |
| ENSVATH13747560 | 241 | V>F | No | 1000Genomes | |
| ENSVATH05081818 | 244 | Q>H | No | 1000Genomes | |
| ENSVATH05081819 | 244 | Q>K | No | 1000Genomes | |
| ENSVATH05081817 | 245 | A>S | No | 1000Genomes | |
| ENSVATH01483507 | 265 | R>Q | No | 1000Genomes | |
| tmp_1_24820831_T_G | 269 | E>D | No | 1000Genomes | |
| ENSVATH13747553 | 283 | V>I | No | 1000Genomes | |
| tmp_1_24820666_T_A | 297 | K>N | No | 1000Genomes | |
| ENSVATH05081809 | 305 | E>Q | No | 1000Genomes | |
| ENSVATH05081808 | 307 | F>I | No | 1000Genomes | |
| ENSVATH01483501 | 338 | K>R | No | 1000Genomes | |
| ENSVATH05081803 | 355 | D>Y | No | 1000Genomes | |
| tmp_1_24820403_T_C | 359 | K>E | No | 1000Genomes | |
| ENSVATH00126835 | 371 | D>E | No | 1000Genomes | |
| ENSVATH01483497 | 374 | Y>C | No | 1000Genomes | |
| tmp_1_24820267_A_C | 374 | Y>D | No | 1000Genomes | |
| tmp_1_24820223_A_C | 388 | D>E | No | 1000Genomes | |
| ENSVATH05081797 | 396 | R>W | No | 1000Genomes | |
| tmp_1_24820153_C_T | 412 | D>N | No | 1000Genomes | |
| tmp_1_24820125_C_T | 421 | R>H | No | 1000Genomes | |
| ENSVATH05081796 | 422 | G>C | No | 1000Genomes | |
| ENSVATH05081796 | 422 | G>S | No | 1000Genomes | |
| ENSVATH05081788 | 457 | Y>* | No | 1000Genomes | |
| ENSVATH14430263 | 468 | K>R | No | 1000Genomes | |
| tmp_1_24819636_C_G | 478 | A>P | No | 1000Genomes | |
| tmp_1_24819503_G_A | 499 | T>I | No | 1000Genomes | |
| tmp_1_24819501_C_T | 500 | G>R | No | 1000Genomes | |
| tmp_1_24819491_G_A | 503 | A>V | No | 1000Genomes | |
| tmp_1_24819486_C_A | 505 | D>Y | No | 1000Genomes | |
| ENSVATH14430261 | 507 | A>G | No | 1000Genomes | |
| tmp_1_24819468_C_G | 511 | A>P | No | 1000Genomes | |
| ENSVATH01483477 | 514 | L>F | No | 1000Genomes | |
| tmp_1_24819456_G_A | 515 | H>Y | No | 1000Genomes | |
| tmp_1_24819438_C_T | 521 | E>K | No | 1000Genomes | |
| tmp_1_24819298_A_G | 540 | Y>H | No | 1000Genomes | |
| ENSVATH13747529 | 544 | E>K | No | 1000Genomes | |
| tmp_1_24819281_C_A | 545 | E>D | No | 1000Genomes | |
| ENSVATH01483473 | 552 | N>Y | No | 1000Genomes | |
| ENSVATH00126823 | 558 | S>T | No | 1000Genomes |
No associated diseases with Q9C713
No regional properties for Q9C713
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q9C713 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 6.1.1.19 | Ligases forming aminoacyl-tRNA and related compounds |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| arginine-tRNA ligase activity | Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| arginyl-tRNA aminoacylation | The process of coupling arginine to arginyl-tRNA, catalyzed by arginyl-tRNA synthetase. The arginyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of an alanine accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. |
| post-embryonic development | The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development. |
| reproductive structure development | The reproductive developmental process whose specific outcome is the progression of somatic structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q05506 | YDR341C | Arginine--tRNA ligase, cytoplasmic | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q0P5H7 | RARS2 | Probable arginine--tRNA ligase, mitochondrial | Bos taurus (Bovine) | PR |
| Q9VXN4 | ArgRS | Probable arginine--tRNA ligase, cytoplasmic | Drosophila melanogaster (Fruit fly) | PR |
| Q5T160 | RARS2 | Probable arginine--tRNA ligase, mitochondrial | Homo sapiens (Human) | PR |
| Q3U186 | Rars2 | Probable arginine--tRNA ligase, mitochondrial | Mus musculus (Mouse) | PR |
| O23247 | EMB1027 | Arginine--tRNA ligase, chloroplastic/mitochondrial | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MATIVASKEF | TGNPRRQLAK | LFDVSLKLTV | PDEPNVEPLI | EPGKFGDYQC | NNAMGLWSLI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KGKGTQFRGP | PAVGQALIQS | LPTSEMVESC | SIAGPGFVNV | VLSSKWMAKS | IENMLVDGID |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TWAPTLSVKR | AVVDFSSPNI | AKEMHVGHLR | STIIGDTLAR | MLEYSKVEVL | RRNHVGDWGT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QFGMLIEFLF | EKFPDTESVT | ETAIGDLQVF | YRESKLKFDL | NPEFKEKAQQ | AVVRLQGGDP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VYRQAWAKIC | EISRNEFAKV | YKRLRIELEE | KGESFYNPYI | ANVIEELSSK | GLVEESKGAR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VIFIEGFKIP | LIVVKSDGGF | NYASTDLTAL | WYRLNEEKAE | WIIYVTDVGQ | QQHFDMFFKA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ARKAGWLPDD | DKTYPRVSHV | GFGLVLGDDN | KRFRTRAAEV | VRLADLLDEA | KDRSKAALIE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| RGKDKEWSPE | ELDQIAEAVG | YGALKYADLK | TNRITGYTFS | FDQMLNDKGD | TAVYLLYAHA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| RICSIIRKSG | KDIDELKKTG | KIALDHAAER | ALGLHLLQFA | ETVEEACTTL | LPNVLCKYLY |
| 550 | 560 | 570 | 580 | ||
| YLSEEFTKFY | SNCQVNGSAE | ETSRLLLCEA | TAIVMRKCFH | LLGITPVYKL |