Q05506
Gene name |
YDR341C (D9651.10) |
Protein name |
Arginine--tRNA ligase, cytoplasmic |
Names |
Arginyl-tRNA synthetase, ArgRS |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YDR341C |
EC number |
6.1.1.19: Ligases forming aminoacyl-tRNA and related compounds |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
4 structures for Q05506
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1BS2 | X-ray | 275 A | A | 1-607 | PDB |
| 1F7U | X-ray | 220 A | A | 1-607 | PDB |
| 1F7V | X-ray | 290 A | A | 1-607 | PDB |
| AF-Q05506-F1 | Predicted | AlphaFoldDB |
5 variants for Q05506
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s04-1153596 | 9 | S>P | No | SGRP | |
| s04-1152683 | 313 | G>D | No | SGRP | |
| s04-1152665 | 319 | K>R | No | SGRP | |
| s04-1152425 | 399 | H>L | No | SGRP | |
| s04-1152094 | 509 | E>D | No | SGRP |
No associated diseases with Q05506
4 regional properties for Q05506
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Aminoacyl-tRNA synthetase, class I, conserved site | 152 - 163 | IPR001412 |
| domain | Arginyl tRNA synthetase N-terminal domain | 33 - 114 | IPR005148 |
| domain | DALR anticodon binding | 489 - 607 | IPR008909 |
| domain | Arginyl-tRNA synthetase, catalytic core domain | 124 - 475 | IPR035684 |
Functions
| Description | ||
|---|---|---|
| EC Number | 6.1.1.19 | Ligases forming aminoacyl-tRNA and related compounds |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| arginine-tRNA ligase activity | Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| arginyl-tRNA aminoacylation | The process of coupling arginine to arginyl-tRNA, catalyzed by arginyl-tRNA synthetase. The arginyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of an alanine accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. |
| mitochondrial translation | The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q0P5H7 | RARS2 | Probable arginine--tRNA ligase, mitochondrial | Bos taurus (Bovine) | PR |
| Q5T160 | RARS2 | Probable arginine--tRNA ligase, mitochondrial | Homo sapiens (Human) | PR |
| Q3U186 | Rars2 | Probable arginine--tRNA ligase, mitochondrial | Mus musculus (Mouse) | PR |
| Q9C713 | At1g66530 | Arginine--tRNA ligase, cytoplasmic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O23247 | EMB1027 | Arginine--tRNA ligase, chloroplastic/mitochondrial | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MASTANMISQ | LKKLSIAEPA | VAKDSHPDVN | IVDLMRNYIS | QELSKISGVD | SSLIFPALEW |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TNTMERGDLL | IPIPRLRIKG | ANPKDLAVQW | AEKFPCGDFL | EKVEANGPFI | QFFFNPQFLA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KLVIPDILTR | KEDYGSCKLV | ENKKVIIEFS | SPNIAKPFHA | GHLRSTIIGG | FLANLYEKLG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| WEVIRMNYLG | DWGKQFGLLA | VGFERYGNEE | ALVKDPIHHL | FDVYVRINKD | IEEEGDSIPL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EQSTNGKARE | YFKRMEDGDE | EALKIWKRFR | EFSIEKYIDT | YARLNIKYDV | YSGESQVSKE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SMLKAIDLFK | EKGLTHEDKG | AVLIDLTKFN | KKLGKAIVQK | SDGTTLYLTR | DVGAAMDRYE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KYHFDKMIYV | IASQQDLHAA | QFFEILKQMG | FEWAKDLQHV | NFGMVQGMST | RKGTVVFLDN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ILEETKEKMH | EVMKKNENKY | AQIEHPEEVA | DLVGISAVMI | QDMQGKRINN | YEFKWERMLS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| FEGDTGPYLQ | YAHSRLRSVE | RNASGITQEK | WINADFSLLK | EPAAKLLIRL | LGQYPDVLRN |
| 550 | 560 | 570 | 580 | 590 | 600 |
| AIKTHEPTTV | VTYLFKLTHQ | VSSCYDVLWV | AGQTEELATA | RLALYGAARQ | VLYNGMRLLG |
| LTPVERM |