AiPD: Autoinhibited Protein Database

Q9BWS9

Gene name	CHID1 (GL008, PSEC0104, SB139)
Protein name	Chitinase domain-containing protein 1
Names	Stabilin-1-interacting chitinase-like protein, SI-CLP
Species	Homo sapiens (Human)
KEGG Pathway	hsa:66005
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-73 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-73 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for Q9BWS9

Entry ID	Method	Resolution	Chain	Position	Source
3BXW	X-ray	270 A	A/B	1-393	PDB
AF-Q9BWS9-F1	Predicted				AlphaFoldDB

348 variants for Q9BWS9

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs115345705 CA5793558	2	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5793559 rs549690523	2	R>W		No	ClinGen ExAC TOPMed gnomAD
rs549420384 CA216989981	3	T>R		No	ClinGen Ensembl
rs764219285 CA5793557	4	L>P		No	ClinGen ExAC gnomAD
rs1335323453 CA378966685	6	N>S		No	ClinGen gnomAD
CA378966688 rs1335323453	6	N>T		No	ClinGen gnomAD
CA378966623 rs1481369979	7	L>P		No	ClinGen TOPMed gnomAD
CA5793556 rs377581510	8	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs1197763557 CA378966564	9	W>C		No	ClinGen gnomAD
rs559255470 CA216989959	12	L>P		No	ClinGen 1000Genomes
rs1364057863 CA378966463	13	A>S		No	ClinGen TOPMed gnomAD
CA378966466 rs1364057863	13	A>T		No	ClinGen TOPMed gnomAD
CA216989956 rs1027394712	14	C>F		No	ClinGen Ensembl
rs765584828 CA5793554	15	S>I		No	ClinGen ExAC gnomAD
CA5793553 rs140024174	16	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA378966290 rs1157404760	17	V>I		No	ClinGen TOPMed gnomAD
CA378966291 rs1157404760	17	V>L		No	ClinGen TOPMed gnomAD
CA5793551 rs369537760	19	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs1565203809 CA378966023	26	A>T		No	ClinGen Ensembl
rs1349198129 CA378965993	26	A>V		No	ClinGen TOPMed
CA216989920 rs897447611	27	K>R		No	ClinGen Ensembl
rs1224101489 CA378965907	28	K>R		No	ClinGen TOPMed gnomAD
rs376582815 CA5793548	30	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA5793547 rs749230118	30	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1221433397 CA378965811	31	S>L		No	ClinGen gnomAD
CA5793546 rs146843043	32	K>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1009120068 CA216989902 COSM1248238	33	T>M	Variant assessed as Somatic; 0.0 impact. oesophagus central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs1225467940 CA378965705	36	E>*		No	ClinGen TOPMed gnomAD
CA378965684 rs1225467940	36	E>K		No	ClinGen TOPMed gnomAD
rs1231394454 CA378963482	38	S>N		No	ClinGen TOPMed gnomAD
rs1298333021 CA378963471	38	S>R		No	ClinGen TOPMed
CA378963454 rs1372199943	39	Q>*		No	ClinGen TOPMed
rs1490599776 CA378963291	42	D>G		No	ClinGen gnomAD
CA5793515 rs754244115	42	D>N		No	ClinGen ExAC gnomAD
rs766738061 CA5793514	44	P>L		No	ClinGen ExAC TOPMed gnomAD
CA216988464 rs867012629	44	P>S		No	ClinGen Ensembl
CA378963170 rs1359316325	45	V>G		No	ClinGen gnomAD
rs200139988 CA378963063	48	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs200139988 CA5793509	48	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs200818734 CA378963053	49	G>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs200818734 CA5793508	49	G>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1441052732 CA378962999	51	V>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA216988408 rs749824532	53	T>M		No	ClinGen gnomAD
CA5793504 rs547880950	59	S>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA216988395 rs148598758	59	S>N		No	ClinGen ESP TOPMed gnomAD
rs148598758 CA378962672	59	S>T		No	ClinGen ESP TOPMed gnomAD
CA378962652 rs1420890430	60	V>L		No	ClinGen gnomAD
CA5793503 rs147773662	62	L>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA378962568 rs1176788602	63	E>G		No	ClinGen gnomAD
rs779066400 CA5793500	64	H>L		No	ClinGen ExAC gnomAD
rs779066400 CA5793501	64	H>R		No	ClinGen ExAC gnomAD
CA5793502 rs772457493	64	H>Y		No	ClinGen ExAC gnomAD
CA378962502 rs1220696886	65	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA5793499 rs754950202	65	R>H		No	ClinGen ExAC TOPMed gnomAD
CA378962476 rs1410845259	66	S>T		No	ClinGen TOPMed
rs568602461 CA5793498	69	S>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs756519811 CA5793496	70	A>G		No	ClinGen ExAC gnomAD
CA378962366 rs1318146960	70	A>T		No	ClinGen gnomAD
rs750755754 CA5793495	73	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA5793494 rs767819599	75	R>G		No	ClinGen ExAC gnomAD
rs1284870348 CA378962100	76	H>R		No	ClinGen gnomAD
CA5793492 rs762679519	78	A>V		No	ClinGen ExAC gnomAD
CA5793491 rs752223525	79	G>R		No	ClinGen ExAC gnomAD
CA5793490 rs149526989	81	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs1262891751 CA378961663	87	P>L		No	ClinGen gnomAD
rs771709076 CA5793484	87	P>S		No	ClinGen ExAC gnomAD
rs1163548201 CA378961323	88	W>G		No	ClinGen TOPMed gnomAD
rs1163548201 CA378961337	88	W>R		No	ClinGen TOPMed gnomAD
CA5793464 rs554156232	89	N>D		No	ClinGen 1000Genomes ExAC gnomAD
CA5793462 rs775559505	93	Y>C		No	ClinGen ExAC gnomAD
rs373864240 CA5793460 COSM1248237	94	D>N	Variant assessed as Somatic; 9.24e-05 impact. oesophagus central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA gnomAD
CA5793457 rs371483155	95	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5793458 rs371483155	95	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5793455 rs147404587	97	K>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed
rs778156977 CA5793456	97	K>R		No	ClinGen ExAC gnomAD
rs753486053 CA5793454	98	V>G		No	ClinGen ExAC gnomAD
rs1363349254 CA378961012	98	V>I		No	ClinGen TOPMed
CA5793452 rs755684842	101	S>R		No	ClinGen ExAC gnomAD
rs904749399 CA216987520	105	Q>H		No	ClinGen TOPMed
CA5793451 rs750446670	106	I>M		No	ClinGen ExAC gnomAD
CA5793450 rs767336380	108	P>A		No	ClinGen ExAC gnomAD
rs267603234 CA5793449	108	P>L		No	ClinGen ExAC TOPMed gnomAD
CA5793447 rs143153872	109	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs763164354 CA5793446	111	L>V		No	ClinGen ExAC gnomAD
rs775684422 CA5793445	112	Q>H		No	ClinGen ExAC gnomAD
CA378960284 rs1301828388	114	K>R		No	ClinGen TOPMed
rs202056261 CA5793444 COSM3953938	116	R>H	lung [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA5793443 rs759586674	117	G>S		No	ClinGen ExAC gnomAD
CA5793442 rs757215367	118	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA5793441 rs771369989	118	R>H		No	ClinGen ExAC TOPMed gnomAD
rs771369989 CA378960159	118	R>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA5793439 rs368061351	120	M>I		No	ClinGen ESP ExAC gnomAD
rs1039909944 CA216987481	120	M>K		No	ClinGen Ensembl
rs747497630 CA5793440	120	M>L		No	ClinGen ExAC TOPMed gnomAD
CA378959998 rs1589893123	123	V>G		No	ClinGen Ensembl
CA216987478 rs946798349	123	V>I		No	ClinGen TOPMed
rs139154177 COSM239321 CA5793438	124	T>M	Variant assessed as Somatic; 0.0 impact. prostate [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs1052435649 CA216987450	125	G>D		No	ClinGen TOPMed gnomAD
rs893907481 CA216987456	125	G>S		No	ClinGen Ensembl
CA216987449 rs935366038	126	L>F		No	ClinGen TOPMed gnomAD
rs935366038 CA378959918	126	L>V		No	ClinGen TOPMed gnomAD
rs199772507 CA5793435	127	H>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5793436 rs779843252	127	H>R		No	ClinGen ExAC gnomAD
rs757164828 CA5793432	128	D>N		No	ClinGen ExAC TOPMed gnomAD
CA5793433 rs757164828	128	D>Y		No	ClinGen ExAC TOPMed gnomAD
rs763860256 CA5793430	129	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1445954455 CA378958429	134	M>I		No	ClinGen TOPMed
COSM1178072 CA5793398 rs762370145	135	R>*	prostate [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA5793397 rs774880059	135	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA216986474 rs909333528	139	K>E		No	ClinGen Ensembl
CA5793396 rs769085275	142	K>E		No	ClinGen ExAC gnomAD
CA378958160 rs1278204752	142	K>R		No	ClinGen TOPMed gnomAD
rs1278204752 CA378958161	142	K>T		No	ClinGen TOPMed gnomAD
CA378958090 rs1341992500	145	H>Y		No	ClinGen gnomAD
rs1268922302 CA378958060	146	I>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1033335167 CA216985789	149	R>Q		No	ClinGen TOPMed
COSM932981 CA378957631 rs1288483282	149	R>W	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA378957597 rs1223932398	151	L>P		No	ClinGen TOPMed
rs767711694 CA5793363	154	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs757397947 CA5793362	156	T>I		No	ClinGen ExAC gnomAD
CA378957502 rs1345976427	156	T>P		No	ClinGen gnomAD
CA378957500 rs1345976427	156	T>S		No	ClinGen gnomAD
rs764630801 CA5793359	157	Y>*		No	ClinGen ExAC TOPMed
rs768146741 CA216985741	157	Y>D		No	ClinGen Ensembl
rs201164951 CA5793357	158	D>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA378957412 rs1460810850	160	F>S		No	ClinGen TOPMed
rs765458236 CA216985709	161	R>L		No	ClinGen ExAC TOPMed gnomAD
rs765458236 CA5793355	161	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA5793356 rs753123596	161	R>W		No	ClinGen ExAC TOPMed gnomAD
CA5793354 rs140948757	163	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs993756327 CA216985688	164	L>F		No	ClinGen Ensembl
rs4963182 CA216985685	165	D>H		No	ClinGen Ensembl
CA378957341 rs1173179201	166	S>G		No	ClinGen TOPMed gnomAD
rs771630933 CA5793352	166	S>N		No	ClinGen ExAC
rs1040582207 CA216985677	168	D>V		No	ClinGen Ensembl
TCGA novel	170	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA378957259 rs1189876604	170	I>T		No	ClinGen gnomAD
CA378957235 rs1243216164	172	E>*		No	ClinGen gnomAD
CA378957180 rs1330686216	174	S>R		No	ClinGen TOPMed gnomAD
TCGA novel	175	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs749130873 CA5793348	176	T>A		No	ClinGen ExAC gnomAD
rs749130873 CA5793349	176	T>S		No	ClinGen ExAC gnomAD
CA5793346 rs769409810	177	V>M		No	ClinGen ExAC TOPMed gnomAD
CA5793343 rs757451317	179	Q>*		No	ClinGen ExAC TOPMed gnomAD
rs777661005 CA378957092	180	V>A		No	ClinGen ExAC TOPMed gnomAD
CA5793341 rs777661005	180	V>G		No	ClinGen ExAC TOPMed gnomAD
CA5793342 COSM119852 rs751719046	180	V>L	ovary Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA5793340 rs758953726	181	A>S		No	ClinGen ExAC gnomAD
rs1441968015 CA378957085	182	K>Q		No	ClinGen TOPMed
CA5793318 rs552920405	186	F>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs552920405 CA5793317	186	F>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA378955894 rs1339909384	187	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs374659275 CA5793315	187	D>V		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	188	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5793313 rs762359264	189	F>L		No	ClinGen ExAC TOPMed gnomAD
rs148078031 CA378955708	190	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs148078031 CA5793311	190	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA378955660 rs765296392	192	E>*		No	ClinGen ExAC TOPMed gnomAD
CA5793310 rs765296392	192	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs1300213384 CA378955630	193	V>A		No	ClinGen TOPMed gnomAD
CA5793309 rs759497306	194	W>*		No	ClinGen ExAC gnomAD
CA378955562 CA5793308 rs746151251	195	N>K		No	ClinGen ExAC TOPMed gnomAD
rs1589884482 CA378955572	195	N>T		No	ClinGen Ensembl
CA378955311 rs1184914743	201	K>N		No	ClinGen gnomAD
CA378955337 rs1369743503	201	K>R		No	ClinGen gnomAD
rs772974142 CA378955298	202	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs773290323 CA5793305	202	R>H		No	ClinGen ExAC TOPMed gnomAD
rs773290323 CA378955269	202	R>L		No	ClinGen ExAC TOPMed gnomAD
rs772974142 CA5793306	202	R>S		No	ClinGen ExAC gnomAD
CA378955248 rs374093920	203	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5793303 rs374093920	203	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA378952679 rs1385725743	204	G>D		No	ClinGen gnomAD
rs1323561385 CA378952717	204	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA216980756 rs867862407	205	L>F		No	ClinGen TOPMed gnomAD
CA216980742 rs112060753	205	L>P		No	ClinGen gnomAD
CA378952608 rs1455281031	206	I>M		No	ClinGen gnomAD
rs1177143037 CA378952564	208	M>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1410800321 CA378952514	209	L>P		No	ClinGen gnomAD
CA216980740 rs1039488094	211	H>Y		No	ClinGen TOPMed
CA216980732 rs962266293	214	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA378952354 rs962266293	214	E>Q		No	ClinGen TOPMed gnomAD
rs1198146591 CA378952251	216	L>V		No	ClinGen gnomAD
CA378952194 rs1250020082	217	H>P		No	ClinGen TOPMed gnomAD
CA378952193 rs1250020082	217	H>R		No	ClinGen TOPMed gnomAD
CA378952108 rs1464572112	218	Q>*		No	ClinGen TOPMed gnomAD
CA378952157 rs1464572112	218	Q>E		No	ClinGen TOPMed gnomAD
rs373338550 CA216980730	218	Q>P		No	ClinGen ESP TOPMed gnomAD
rs113850108 CA5793291	219	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs11541325 CA378951978	220	R>L		No	ClinGen TOPMed gnomAD
CA216980726 rs11541325	220	R>Q		No	ClinGen TOPMed gnomAD
CA5793290 rs776704672	220	R>W		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	224	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA378951869 rs1203610916	225	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA378951807 rs1240249210	227	I>T		No	ClinGen gnomAD
rs953434134 CA216980724	227	I>V		No	ClinGen TOPMed gnomAD
CA216980722 rs1028958102	228	P>L		No	ClinGen gnomAD
TCGA novel	228	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA216980711 rs1000113020	229	P>L		No	ClinGen Ensembl
rs1399858508 CA378951680	230	A>T		No	ClinGen gnomAD
rs1589865595 CA378951591	232	T>P		No	ClinGen Ensembl
rs1391970697 CA378951562	233	P>L		No	ClinGen gnomAD
CA378951555 rs1267678898	234	G>R		No	ClinGen TOPMed
CA378946373 rs1420444013	235	T>S		No	ClinGen gnomAD
rs905315937 CA216971750	236	D>E		No	ClinGen gnomAD
rs143837907 CA5793267	236	D>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA378946259 CA216971749 rs149001064	240	M>I		No	ClinGen ESP
COSM932853 CA5793265 rs146861158	242	T>M	endometrium [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA378946149 rs1489063390	244	K>R		No	ClinGen gnomAD
rs1589842602 CA378946004	248	Q>H		No	ClinGen Ensembl
CA5793263 rs775506286	249	L>V		No	ClinGen ExAC
CA5793262 rs770223032	250	A>S		No	ClinGen ExAC gnomAD
CA5793261 rs746324429	250	A>V		No	ClinGen ExAC gnomAD
rs781411027 CA5793260	251	P>A		No	ClinGen ExAC gnomAD
CA5793257 rs536210286	252	V>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs376597827 CA216971696	252	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs376597827 CA5793258	252	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs754573713 CA5793256	256	F>L		No	ClinGen ExAC gnomAD
TCGA novel	257	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1486910105 CA378945819	260	T>I		No	ClinGen TOPMed
CA5793254 rs779663358	262	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1487507985 CA378945787	262	D>V		No	ClinGen TOPMed
CA378945763 rs1434380846	263	Y>C		No	ClinGen gnomAD
CA378945768 rs1295292498	263	Y>H		No	ClinGen gnomAD
rs1190584151 CA378945734	264	S>A		No	ClinGen TOPMed
rs756019950 CA5793253	265	T>A		No	ClinGen ExAC gnomAD
rs767285671 CA378945705	266	A>G		No	ClinGen ExAC TOPMed gnomAD
rs767285671 CA5793251	266	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1434120976 CA378945686	267	H>R		No	ClinGen gnomAD
rs1158810657 CA378945697	267	H>Y		No	ClinGen gnomAD
CA216970917 rs1038103160	272	N>H		No	ClinGen TOPMed
rs758620003 CA5793228	272	N>K		No	ClinGen ExAC gnomAD
rs752907443 CA5793226	273	A>E		No	ClinGen ExAC gnomAD
rs752907443 CA378944576	273	A>V		No	ClinGen ExAC gnomAD
rs942468617 CA216970905	275	L>V		No	ClinGen TOPMed
CA378944537 rs1396787401	276	S>F		No	ClinGen gnomAD
rs766939366 CA5793222	277	W>*		No	ClinGen ExAC gnomAD
CA378944514 rs777043780	277	W>G		No	ClinGen ExAC TOPMed gnomAD
CA5793223 rs777043780	277	W>R		No	ClinGen ExAC TOPMed gnomAD
rs376968788 CA5793221	278	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs1171104679 CA378944416	279	R>*		No	ClinGen TOPMed gnomAD
CA5793220 rs773727065	279	R>Q		No	ClinGen ExAC gnomAD
rs1426407248 CA378944386	280	A>D		No	ClinGen TOPMed gnomAD
rs772499627 CA5793219	280	A>P		No	ClinGen ExAC gnomAD
CA5793218 rs749015751	281	C>S		No	ClinGen ExAC TOPMed gnomAD
CA5793216 rs769240188	282	V>I		No	ClinGen ExAC TOPMed gnomAD
rs745355777 CA5793212	285	L>M		No	ClinGen ExAC gnomAD
CA378944261 rs1252429427	285	L>P		No	ClinGen gnomAD
rs1168139248 CA378944193	287	P>A		No	ClinGen TOPMed
CA5793210 rs757197761	287	P>L		No	ClinGen ExAC TOPMed gnomAD
CA378944152 rs757197761	287	P>R		No	ClinGen ExAC TOPMed gnomAD
CA216970833 rs954810231	290	K>E		No	ClinGen gnomAD
rs1310933713 CA378943948	291	W>*		No	ClinGen TOPMed gnomAD
rs1414539386 CA378943912	292	R>*		No	ClinGen gnomAD
CA378943905 rs758172690	292	R>L		No	ClinGen ExAC gnomAD
rs758172690 CA5793207	292	R>Q		No	ClinGen ExAC gnomAD
rs755114027 CA5793204	299	L>F		No	ClinGen ExAC gnomAD
rs373872718 CA216970818	302	Y>C		No	ClinGen ESP TOPMed
rs1295353338 CA378943323	304	M>V		No	ClinGen TOPMed
CA378943243 rs1369829408	305	D>G		No	ClinGen gnomAD
TCGA novel	305	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs768941590 CA216970795	307	A>G		No	ClinGen ExAC TOPMed gnomAD
rs766313099 CA5793201	307	A>T		No	ClinGen ExAC gnomAD
COSM932838 CA5793200 rs768941590	307	A>V	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs762249594 CA5793197	308	T>A		No	ClinGen ExAC gnomAD
CA216970786 rs149684575	308	T>I		No	ClinGen ESP gnomAD
rs878890981 CA216970782	309	S>F		No	ClinGen Ensembl
rs1023635066 CA216970781	310	K>R		No	ClinGen TOPMed
rs1487517317 CA378942997	311	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA5793195 rs769521441	312	A>S		No	ClinGen ExAC TOPMed gnomAD
rs893719722 CA216970774	312	A>V		No	ClinGen Ensembl
CA5793194 rs745451507 COSM178087	313	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA5793193 rs776207830	313	R>H		No	ClinGen ExAC TOPMed gnomAD
CA216970766 rs770419040	316	V>I		No	ClinGen ExAC gnomAD
CA5793192 rs770419040	316	V>L		No	ClinGen ExAC gnomAD
rs1589839862 CA378942835	317	V>D		No	ClinGen Ensembl
rs573813834 CA378942842	317	V>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5793190 rs573813834	317	V>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5793187 CA5793188 rs761220629	318	G>R		No	ClinGen ExAC TOPMed gnomAD
rs778522335 CA5793186	319	A>V		No	ClinGen ExAC gnomAD
rs772721428 CA5793153	322	I>S		No	ClinGen ExAC gnomAD
CA378936557 rs1441106376	324	T>I		No	ClinGen gnomAD
CA378936509 rs1216459839	328	H>R		No	ClinGen TOPMed
CA5793150 rs774142546	330	P>S		No	ClinGen ExAC gnomAD
rs1127800 CA378936472	331	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5793148 rs1127800 VAR_031173	331	R>Q		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA5793149 rs142743201	331	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs775389483 CA5793147	332	M>I		No	ClinGen ExAC gnomAD
rs1371190923 CA378936438	334	W>*		No	ClinGen Ensembl
rs1449934133 CA378936426	335	D>N		No	ClinGen TOPMed gnomAD
CA378936401 rs1245837767	336	S>I		No	ClinGen TOPMed
CA5793145 rs746032586	337	Q>P		No	ClinGen ExAC TOPMed gnomAD
rs6682 CA216958713	338	A>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5793143 rs757268762	338	A>T		No	ClinGen ExAC gnomAD
rs6682 CA5793142 VAR_031174	338	A>V		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs374232737 CA5793141	340	E>G		No	ClinGen ESP ExAC gnomAD
CA378936348 rs1326860808	340	E>K		No	ClinGen TOPMed gnomAD
CA378936345 rs1326860808	340	E>Q		No	ClinGen TOPMed gnomAD
rs370672044 CA5793140	341	H>Y		No	ClinGen ESP ExAC gnomAD
rs765526454 CA5793138	342	F>L	Variant assessed as Somatic; 4.734e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA378936286 rs1589810818	342	F>S		No	ClinGen Ensembl
CA378936292 rs1417546339	342	F>V		No	ClinGen gnomAD
CA5793136 rs142808709	343	F>L		No	ClinGen ESP ExAC gnomAD
CA5793137 rs755766935	343	F>L		No	ClinGen ExAC gnomAD
rs772327238 CA216958705	344	E>D		No	ClinGen TOPMed gnomAD
CA378936255 rs1201815172	344	E>K		No	ClinGen TOPMed gnomAD
rs761206835 CA5793134	346	K>Q		No	ClinGen ExAC gnomAD
rs774390750 CA5793133	347	K>*		No	ClinGen ExAC gnomAD
rs1441853400 CA378935918	349	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA5793109 rs140476082	349	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA5793108 rs370593417	350	S>G		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	354	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA378935660 rs748714060	354	V>F		No	ClinGen ExAC TOPMed gnomAD
rs748714060 CA5793105	354	V>I		No	ClinGen ExAC TOPMed gnomAD
rs138166915 CA5793104	355	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs138166915 CA378935589	355	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs769049099 CA5793103	356	F>Y		No	ClinGen ExAC gnomAD
rs1589809839 CA378935492	357	Y>C		No	ClinGen Ensembl
rs1589809823 CA378935393	359	T>P		No	ClinGen Ensembl
rs761978057 CA5793067	362	S>Y		No	ClinGen ExAC gnomAD
CA5793065 rs764097989	363	L>M		No	ClinGen ExAC gnomAD
CA5793063 rs763441480	364	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA5793061 rs374883925	366	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA5793062 rs142286202	366	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs771863477 CA5793059	368	E>A		No	ClinGen ExAC gnomAD
rs771863477 CA5793058	368	E>G		No	ClinGen ExAC gnomAD
rs1210528761 CA378934630	369	L>V		No	ClinGen gnomAD
rs747733825 CA378934588	371	R>G		No	ClinGen ExAC TOPMed gnomAD
CA5793056 rs778633553	371	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA5793057 rs747733825	371	R>W	Variant assessed as Somatic; 4.631e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs754522495 CA5793055	373	L>P		No	ClinGen ExAC gnomAD
rs750256778 CA5793051	375	V>A		No	ClinGen ExAC gnomAD
CA5793052 rs556045828	375	V>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1372720094 CA378934357	377	V>F		No	ClinGen TOPMed gnomAD
CA216958286 rs754145886	378	S>C		No	ClinGen TOPMed gnomAD
rs1468389732 CA378934204	380	W>*		No	ClinGen gnomAD
rs934223496 CA216958275	382	L>P		No	ClinGen TOPMed gnomAD
rs1369931568 CA378934133	382	L>V		No	ClinGen gnomAD
CA5793047 rs545997593	383	G>D		No	ClinGen 1000Genomes ExAC
CA5793048 rs751780638	383	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1199673911 CA378933966	386	L>R		No	ClinGen gnomAD
rs775388800 CA5793044	387	D>V		No	ClinGen ExAC
rs1303411346 CA378933918	388	Y>D		No	ClinGen TOPMed
rs1378154990 CA378933884	389	F>Y		No	ClinGen TOPMed
rs765793433 CA378933862	390	Y>C		No	ClinGen ExAC gnomAD
CA378933872 rs1251345734	390	Y>N		No	ClinGen TOPMed gnomAD
rs765793433 CA5793043	390	Y>S		No	ClinGen ExAC gnomAD
CA5793041 rs777138598	391	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs182950163 CA216958253	393	L>F		No	ClinGen 1000Genomes gnomAD

No associated diseases with Q9BWS9

2 regional properties for Q9BWS9

Type	Name	Position	InterPro Accession
domain	Glycoside hydrolase family 18, catalytic domain	79 - 393	IPR001223
domain	Chitinase II	79 - 385	IPR011583

Functions

		Description
EC Number
Subcellular Localization	Secreted Lysosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

9 GO annotations of cellular component

Name	Definition
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
extracellular region	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
extracellular space	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
late endosome	A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
lysosomal lumen	The volume enclosed within the lysosomal membrane.
lysosome	A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
trans-Golgi network	The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.

2 GO annotations of molecular function

Name	Definition
chitin binding	Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues.
oligosaccharide binding	Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages.

3 GO annotations of biological process

Name	Definition
carbohydrate metabolic process	The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
innate immune response	Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
negative regulation of cytokine production involved in inflammatory response	Any process that stops, prevents or reduces the frequency, rate or extent of cytokine production involved in inflammatory response.

3 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q5EAB4	CHID1	Chitinase domain-containing protein 1	Bos taurus (Bovine)	PR
Q922Q9	Chid1	Chitinase domain-containing protein 1	Mus musculus (Mouse)	PR
A0JPQ9	Chid1	Chitinase domain-containing protein 1	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MRTLFNLLWL	ALACSPVHTT	LSKSDAKKAA	SKTLLEKSQF	SDKPVQDRGL	VVTDLKAESV
70	80	90	100	110	120
VLEHRSYCSA	KARDRHFAGD	VLGYVTPWNS	HGYDVTKVFG	SKFTQISPVW	LQLKRRGREM
130	140	150	160	170	180
FEVTGLHDVD	QGWMRAVRKH	AKGLHIVPRL	LFEDWTYDDF	RNVLDSEDEI	EELSKTVVQV
190	200	210	220	230	240
AKNQHFDGFV	VEVWNQLLSQ	KRVGLIHMLT	HLAEALHQAR	LLALLVIPPA	ITPGTDQLGM
250	260	270	280	290	300
FTHKEFEQLA	PVLDGFSLMT	YDYSTAHQPG	PNAPLSWVRA	CVQVLDPKSK	WRSKILLGLN
310	320	330	340	350	360
FYGMDYATSK	DAREPVVGAR	YIQTLKDHRP	RMVWDSQASE	HFFEYKKSRS	GRHVVFYPTL
370	380	390
KSLQVRLELA	RELGVGVSIW	ELGQGLDYFY	DLL