Q5EAB4

PR
Gene name
CHID1
Protein name
Chitinase domain-containing protein 1
Names
Species
Bos taurus (Bovine)
KEGG Pathway
bta:504781
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-72 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5EAB4

Entry ID Method Resolution Chain Position Source
AF-Q5EAB4-F1 Predicted AlphaFoldDB

138 variants for Q5EAB4

Variant ID(s) Position Change Description Diseaes Association Provenance
rs455016967 3 V>G No EVA
rs444080424 11 T>P No EVA
rs477607521 18 H>L No EVA
rs477607521 18 H>P No EVA
rs438319107 20 T>P No EVA
rs459803737 38 T>S No EVA
rs442021573 46 Q>E No EVA
rs463751753 46 Q>H No EVA
rs482365454 47 E>Q No EVA
rs446300226 47 E>V No EVA
rs464647294 51 V>G No EVA
rs479829300 54 D>G No EVA
rs447007641 66 S>N No EVA
rs527058972 74 R>K No EVA
rs465848647 75 K>T No EVA
rs454480483 80 D>A No EVA
rs469769250 83 G>C No EVA
rs452431652 85 I>V No EVA
rs470846990 86 T>M No EVA
rs456773785 88 W>L No EVA
rs471992444 95 V>F No EVA
rs438983587 96 A>G No EVA
rs457858067 111 L>R No EVA
rs479527973 122 E>* No EVA
rs440018371 130 D>A No EVA
rs436322265 133 W>R No EVA
rs454512222 140 Q>R No EVA
rs476235778 145 R>C No EVA
rs380616187 145 R>H No EVA
rs380616187 145 R>L No EVA
rs473140132 149 R>C No EVA
rs520918393 163 V>A No EVA
rs433761042 171 E>* No EVA
rs455425246 173 L>H No EVA
rs473897229 174 S>R No EVA
rs444334514 176 T>S No EVA
rs456048552 177 V>A No EVA
rs471428052 182 K>N No EVA
rs465159460 187 D>H No EVA
rs432234118 196 Q>H No EVA
rs447604189 199 V>F No EVA
rs478466929 204 G>E No EVA
rs445445663 206 I>L No EVA
rs467265671 209 L>V No EVA
rs479350439 210 T>P No EVA
rs449286203 212 M>I No EVA
rs467799073 215 A>G No EVA
rs469109896 217 H>P No EVA
rs451444165 219 A>S No EVA
rs440295207 224 F>C No EVA
rs455147787 226 V>G No EVA
rs473847623 227 I>T No EVA
rs444057617 231 V>L No EVA
rs462655609 232 A>P No EVA
rs439016574 234 G>E No EVA
rs439016574 234 G>V No EVA
rs478004969 234 G>W No EVA
rs377906634 244 T>M No EVA
rs799399512 246 F>V No EVA
rs724011555 246 F>Y No EVA
rs454295985 269 A>P No EVA
rs443068731 273 A>E No EVA
rs455144361 274 P>R No EVA
rs476982795 275 L>R No EVA
rs458812244 278 V>G No EVA
rs477284322 281 C>R No EVA
rs477284322 281 C>S No EVA
rs441288929 282 V>F No EVA
rs449117214 285 L>P No EVA
rs467635046 286 D>A No EVA
rs482951653 287 P>R No EVA
rs449683566 289 S>F No EVA
rs464986685 290 K>E No EVA
rs464986685 290 K>Q No EVA
rs466334616 291 W>L No EVA
rs453754202 291 W>R No EVA
rs436577174 293 S>G No EVA
rs455162384 293 S>R No EVA
rs443923639 294 K>N No EVA
rs476923767 294 K>Q No EVA
rs452361299 295 I>L No EVA
rs441221323 296 L>P No EVA
rs442577055 299 L>I No EVA
rs461182363 299 L>R No EVA
rs442577055 299 L>V No EVA
rs482888425 300 N>H No EVA
rs450024579 300 N>K No EVA
rs476998201 301 F>L No EVA
rs458490883 301 F>L No EVA
rs447280148 302 Y>N No EVA
rs465813806 303 G>R No EVA
rs465813806 303 G>S No EVA
rs448560330 304 M>I No EVA
rs437423470 306 Y>C No EVA
rs470230318 306 Y>H No EVA
rs452699817 307 S>T No EVA
rs434769430 308 A>G No EVA
rs453316422 310 K>E No EVA
rs453316422 310 K>Q No EVA
rs475088637 311 D>E No EVA
rs461071564 313 R>P No EVA
rs443501687 314 E>A No EVA
rs476415877 314 E>Q No EVA
rs458825462 316 I>N No EVA
rs477338065 317 I>N No EVA
rs384919171 319 A>T No EVA
rs463740812 324 T>K No EVA
rs441682458 324 T>P No EVA
rs482221062 331 Q>* No EVA
rs446242613 332 V>A No EVA
rs480198826 338 A>S No EVA
rs446804848 341 H>R No EVA
rs451024767 344 E>D No EVA
rs435636963 344 E>G No EVA
rs475515323 352 R>G No EVA
rs439299925 352 R>T No EVA
rs449996380 358 P>R No EVA
rs467516714 363 L>S No EVA
rs456745988 367 L>R No EVA
rs438191519 367 L>V No EVA
rs432681869 368 E>G No EVA
rs472045589 368 E>K No EVA
rs472404127 369 L>P No EVA
rs472404127 369 L>Q No EVA
rs461269026 370 A>G No EVA
rs476548438 371 Q>L No EVA
rs476548438 371 Q>P No EVA
rs478121882 372 E>D No EVA
rs462776205 372 E>G No EVA
rs445137835 373 L>R No EVA
rs448942677 375 V>G No EVA
rs467445258 377 L>M No EVA
rs437712854 377 L>R No EVA
rs465584374 378 S>P No EVA
rs432628486 378 S>Y No EVA
rs472746273 379 I>S No EVA
rs436339261 381 E>G No EVA
rs476487069 385 G>C No EVA

No associated diseases with Q5EAB4

2 regional properties for Q5EAB4

Type Name Position InterPro Accession
domain Glycoside hydrolase family 18, catalytic domain 79 - 393 IPR001223
domain Chitinase II 79 - 385 IPR011583

Functions

Description
EC Number
Subcellular Localization
  • Secreted
  • Lysosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
lysosome A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.

2 GO annotations of molecular function

Name Definition
chitin binding Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues.
oligosaccharide binding Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages.

2 GO annotations of biological process

Name Definition
carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9BWS9 CHID1 Chitinase domain-containing protein 1 Homo sapiens (Human) PR
Q922Q9 Chid1 Chitinase domain-containing protein 1 Mus musculus (Mouse) PR
A0JPQ9 Chid1 Chitinase domain-containing protein 1 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MRVLLGTLWL TLACSSVHAT LSKSDAKKAA SKTLQEKTQV SGKPAQERGL VVTDLRAEDV
70 80 90 100 110 120
VLEHRSYCSA KAHRKHFAGD VLGYITPWNR HGYDVAKIFG GKFTHVAPVW LQLRRHGREM
130 140 150 160 170 180
FEVTGLDDVD QGWLRAVRKQ AKGLRIVPRL RFEDWTYEDF DSVLDNEDEI EELSRTVVQV
190 200 210 220 230 240
AKSQHFDGLV VEVWNQLLVQ KHAGLIHLLT HMAEALHQAR LLVFLVIPPA VAPGTNKLGM
250 260 270 280 290 300
FTNTEFEQLA PVLDGFSLMT YDYSTAQPAG PNAPLPWVRA CVQVLDPKSK WRSKILLGLN
310 320 330 340 350 360
FYGMDYSASK DAREPIIGAR YIQTLKDHRP QVVWDSQAAE HFFEYKKSRG GRHVVFYPTL
370 380 390
KSLQERLELA QELGVGLSIW ELGQGLDYFY DLL