Q99PI5
PR
Gene name |
Lpin2 |
Protein name |
Phosphatidate phosphatase LPIN2 |
Names |
Lipin-2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:64898 |
EC number |
3.1.3.4: Phosphoric monoester hydrolases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q99PI5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 7KIQ | X-ray | 252 A | A/B/C/D/E/F/G/H/I/J | 459-549 | PDB |
| AF-Q99PI5-F1 | Predicted | AlphaFoldDB |
57 variants for Q99PI5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389478815 | 4 | V>M | No | EVA | |
| rs3389489609 | 14 | T>A | No | EVA | |
| rs3389479377 | 24 | Q>H | No | EVA | |
| rs3389470102 | 29 | G>A | No | EVA | |
| rs864263291 | 39 | Q>L | No | EVA | |
| rs3389481394 | 49 | H>L | No | EVA | |
| rs3389437613 | 69 | I>N | No | EVA | |
| rs3389478810 | 73 | A>T | No | EVA | |
| rs3389446864 | 79 | K>R | No | EVA | |
| rs3389478802 | 87 | F>L | No | EVA | |
| rs107726727 | 125 | S>P | No | EVA | |
| rs3389494225 | 154 | K>R | No | EVA | |
| rs3408011749 | 164 | Q>* | No | EVA | |
| rs3389446855 | 172 | A>G | No | EVA | |
| rs3389472894 | 179 | D>Y | No | EVA | |
| rs3407926542 | 205 | K>N | No | EVA | |
| rs864273097 | 245 | S>F | No | EVA | |
| rs3389470024 | 249 | V>M | No | EVA | |
| rs3389478826 | 265 | T>M | No | EVA | |
| rs3389472848 | 266 | W>* | No | EVA | |
| rs3389485021 | 278 | R>K | No | EVA | |
| rs3389472851 | 291 | T>A | No | EVA | |
| rs233411544 | 321 | T>S | No | EVA | |
| rs3389481431 | 354 | I>V | No | EVA | |
| rs220121637 | 375 | K>R | No | EVA | |
| rs3389446843 | 387 | G>S | No | EVA | |
| rs3389446819 | 416 | Y>D | No | EVA | |
| rs3407880668 | 439 | Q>H | No | EVA | |
| rs3389494292 | 451 | S>N | No | EVA | |
| rs3389470061 | 499 | P>H | No | EVA | |
| rs3408093559 | 507 | L>SKI* | No | EVA | |
| rs3389427969 | 508 | V>L | No | EVA | |
| rs3389457314 | 539 | T>I | No | EVA | |
| rs3389446831 | 555 | W>* | No | EVA | |
| rs3389494265 | 570 | E>K | No | EVA | |
| rs3389478411 | 591 | P>R | No | EVA | |
| rs263009407 | 592 | T>S | No | EVA | |
| rs3389479454 | 595 | R>I | No | EVA | |
| rs3389457373 | 630 | A>T | No | EVA | |
| rs3389472537 | 658 | S>N | No | EVA | |
| rs250094278 | 677 | N>D | No | EVA | |
| rs212288053 | 679 | N>S | No | EVA | |
| rs3389478828 | 701 | L>F | No | EVA | |
| rs3389489630 | 714 | A>T | No | EVA | |
| rs3389481464 | 732 | A>T | No | EVA | |
| rs3389494252 | 742 | R>P | No | EVA | |
| rs3389472598 | 743 | G>D | No | EVA | |
| rs3389470090 | 764 | P>L | No | EVA | |
| rs3389472538 | 772 | H>Q | No | EVA | |
| rs3389470071 | 789 | N>I | No | EVA | |
| rs108530074 | 799 | R>K | No | EVA | |
| rs3408277529 | 814 | Y>* | No | EVA | |
| rs3407945254 | 816 | Y>S | No | EVA | |
| rs3407945301 | 817 | T>S | No | EVA | |
| rs3408011736 | 820 | G>E | No | EVA | |
| rs3389446850 | 844 | K>R | No | EVA | |
| rs3389481472 | 882 | D>Y | No | EVA |
No associated diseases with Q99PI5
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.3.4 | Phosphoric monoester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| phosphatidate phosphatase activity | Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate. |
| transcription coactivator activity | A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular lipid metabolic process | The chemical reactions and pathways involving lipids, as carried out by individual cells. |
| cellular response to insulin stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. |
| fatty acid catabolic process | The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. |
| lipid metabolic process | The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| triglyceride biosynthetic process | The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9BQK8 | LPIN3 | Phosphatidate phosphatase LPIN3 | Homo sapiens (Human) | PR |
| Q14693 | LPIN1 | Phosphatidate phosphatase LPIN1 | Homo sapiens (Human) | PR |
| Q92539 | LPIN2 | Phosphatidate phosphatase LPIN2 | Homo sapiens (Human) | PR |
| Q91ZP3 | Lpin1 | Phosphatidate phosphatase LPIN1 | Mus musculus (Mouse) | PR |
| Q9FMN2 | PAH2 | Phosphatidate phosphatase PAH2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNYVGQLAGQ | VLVTVKELYK | GINQATLSGC | IDVVVVRQQD | GSYQCSPFHV | RFGKLGVLRS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KEKVIDIEIN | GSAVDLHMKL | GDNGEAFFVE | ETEEEYEKLP | AYLATSPIPT | EDQFFKHIET |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PLVKSSGNER | PAQSSDVSHT | LESEAVFTQS | SVKKKKRRRK | KCKQDNRKEE | QAASPVAEDV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GDVGVSSDDE | KRAQAARGSS | NASLKEEDYK | EPSLFHSGDN | YPLSDGDWSP | LETTYPQAVC |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PKSDSELEVK | PSESLLRSEP | HMEWTWGGFP | ESTKVTKRER | YDYHPRTATI | TPSENTHFRV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IPSEDSLIRE | VEKDATVEDT | TCTIVKPKPR | ALCKQLSDAA | STELPESPLE | APQISSLLDA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DPVPSPSAEA | PSEPKPAAKD | SPTKKKGVHK | RSQHQGPDDI | YLDDLKALEP | EVAALYFPKS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DTDPGSRQWP | ESDTFSGSQS | PQSVGSAAAD | SGTECLSDSA | MDLPDVTLSL | CGGLSENGEI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SKEKFMEHII | TYHEFAENPG | LIDNPNLVIR | IYNRYYNWAL | AAPMILSLQV | FQKSLPKATV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ESWVKDKMPK | KSGRWWFWRK | KESMIKQLPE | TKEGKSEVPP | ANDLPSNAEE | PTSARPAEND |
| 610 | 620 | 630 | 640 | 650 | 660 |
| TSSDEGSQEL | EESIKVDPIT | VETLSHCGTA | SYKKSLRLSS | DQIAKLKLHD | GPNDVVFSIT |
| 670 | 680 | 690 | 700 | 710 | 720 |
| TQYQGTCRCA | GTIYLWNWND | KVIISDIDGT | ITKSDALGQI | LPQLGKDWTH | QGIARLYHSI |
| 730 | 740 | 750 | 760 | 770 | 780 |
| NENGYKFLYC | SARAIGMADM | TRGYLHWVND | KGTILPRGPL | MLSPSSLFSA | FHREVIEKKP |
| 790 | 800 | 810 | 820 | 830 | 840 |
| EKFKIECLND | IKNLFAPSRQ | PFYAAFGNRP | NDVYAYTQVG | VPDCRIFTVN | PKGELIQERT |
| 850 | 860 | 870 | 880 | 890 | |
| KGNKSSYHRL | SELVEHVFPL | LSKEQNSAFP | CPEFSSFCYW | RDPIPDLDLD | DLA |