Q91ZP3

PR
Gene name
Lpin1 (Flde)
Protein name
Phosphatidate phosphatase LPIN1
Names
Fatty liver dystrophy protein, Lipin-1
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:14245
EC number
3.1.3.4: Phosphoric monoester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

68-516 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for Q91ZP3

Entry ID Method Resolution Chain Position Source
7KIH X-ray 147 A A 491-581 PDB
7KIL X-ray 190 A A/B 491-581 PDB
AF-Q91ZP3-F1 Predicted AlphaFoldDB

1 variants for Q91ZP3

Variant ID(s) Position Change Description Diseaes Association Provenance
84 G>R allele FLD2J; causes the fatty liver dystrophy phenotype (fld), characterized by neonatal fatty liver and hypertriglyceridemia that resolve at weaning and neuropathy affecting peripheral nerve in adulthood [UniProt] No

1 associated diseases with Q91ZP3

Without disease ID

4 regional properties for Q91ZP3

Type Name Position InterPro Accession
domain Lipin, N-terminal 1 - 107 IPR007651
domain Lipin/Ned1/Smp2 (LNS2) 660 - 885 IPR013209
domain LNS2/PITP 708 - 864 IPR031315
domain Lipin, middle domain 498 - 591 IPR031703

Functions

Description
EC Number 3.1.3.4 Phosphoric monoester hydrolases
Subcellular Localization
  • [Isoform 1]: Mitochondrion outer membrane
  • Cytoplasm
  • Nucleus membrane
  • Recruited at the mitochondrion outer membrane following phosphatidic acid formation mediated by PLD6
  • In neuronals cells, isoform 1 is exclusively cytoplasmic (PubMed:21397848)
  • In 3T3-L1 pre-adipocytes, it primarily located in the cytoplasm (PubMed:16049017)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

8 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
mitochondrial outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
nuclear membrane Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
transcription regulator complex A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.

5 GO annotations of molecular function

Name Definition
histone deacetylase binding Binding to histone deacetylase.
peroxisome proliferator activated receptor binding Binding to a peroxisome proliferator activated receptor, alpha, beta or gamma.
phosphatidate phosphatase activity Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.
RNA polymerase II-specific DNA-binding transcription factor binding Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription.
transcription coactivator activity A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator.

20 GO annotations of biological process

Name Definition
actin cytoskeleton reorganization A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins.
cellular lipid metabolic process The chemical reactions and pathways involving lipids, as carried out by individual cells.
cellular response to insulin stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
fat cell differentiation The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat.
fatty acid catabolic process The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
immune response Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
mitochondrial fission The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments.
negative regulation of myelination Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of a myelin sheath around nerve axons.
negative regulation of phosphatidate phosphatase activity Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidate phosphatase activity.
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
phosphatidic acid metabolic process The chemical reactions and pathways involving phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.
positive regulation of cold-induced thermogenesis Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.
positive regulation of DNA replication Any process that activates or increases the frequency, rate or extent of DNA replication.
positive regulation of histone deacetylation Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of fat cell differentiation Any process that modulates the frequency, rate or extent of adipocyte differentiation.
ruffle organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ruffle, a projection at the leading edge of a crawling cell.
triglyceride biosynthetic process The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol.
triglyceride mobilization The release of triglycerides, any triester of glycerol, from storage within cells or tissues, making them available for metabolism.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q92539 LPIN2 Phosphatidate phosphatase LPIN2 Homo sapiens (Human) PR
Q9BQK8 LPIN3 Phosphatidate phosphatase LPIN3 Homo sapiens (Human) PR
Q14693 LPIN1 Phosphatidate phosphatase LPIN1 Homo sapiens (Human) PR
Q99PI5 Lpin2 Phosphatidate phosphatase LPIN2 Mus musculus (Mouse) PR
Q9FMN2 PAH2 Phosphatidate phosphatase PAH2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MNYVGQLAGQ VFVTVKELYK GLNPATLSGC IDIIVIRQPN GSLQCSPFHV RFGKMGVLRS
70 80 90 100 110 120
REKVVDIEIN GESVDLHMKL GDNGEAFFVQ ETDNDQEIIP MYLATSPILS EGAARMESQL
130 140 150 160 170 180
KRNSVDRIRC LDPTTAAQGL PPSDTPSTGS LGKKRRKRRR KAQLDNLKRD DNVNSSEDED
190 200 210 220 230 240
MFPIEMSSDE DTAPMDGSRT LPNDVPPFQD DIPKENFPSI STHPQSASYP SSDREWSPSP
250 260 270 280 290 300
SSLVDCQRTP PHLAEGVLSS SCPLQSCHFH ASESPSGSRP STPKSDSELV SKSADRLTPK
310 320 330 340 350 360
NNLEMLWLWG ELPQAAKSSS PHKMKESSPL GSRKTPDKMN FQAIHSESSD TFSDQSPTMA
370 380 390 400 410 420
RGLLIHQSKA QTEMQFVNEE DLESLGAAAP PSPVAEELKA PYPNTAQSSS KTDSPSRKKD
430 440 450 460 470 480
KRSRHLGADG VYLDDLTDMD PEVAALYFPK NGDPGGLPKQ ASDNGARSAN QSPQSVGGSG
490 500 510 520 530 540
IDSGVESTSD SLRDLPSIAI SLCGGLSDHR EITKDAFLEQ AVSYQQFADN PAIIDDPNLV
550 560 570 580 590 600
VKVGNKYYNW TTAAPLLLAM QAFQKPLPKA TVESIMRDKM PKKGGRWWFS WRGRNATIKE
610 620 630 640 650 660
ESKPEQCLTG KGHNTGEQPA QLGLATRIKH ESSSSDEEHA AAKPSGSSHL SLLSNVSYKK
670 680 690 700 710 720
TLRLTSEQLK SLKLKNGPND VVFSVTTQYQ GTCRCEGTIY LWNWDDKVII SDIDGTITRS
730 740 750 760 770 780
DTLGHILPTL GKDWTHQGIA KLYHKVSQNG YKFLYCSARA IGMADMTRGY LHWVNERGTV
790 800 810 820 830 840
LPQGPLLLSP SSLFSALHRE VIEKKPEKFK VQCLTDIKNL FFPNTEPFYA AFGNRPADVY
850 860 870 880 890 900
SYKQVGVSLN RIFTVNPKGE LVQEHAKTNI SSYVRLCEVV DHVFPLLKRS HSCDFPCSDT
910 920
FSNFTFWREP LPPFENQDMH SASA