Q99ME9
PR
Gene name |
Gtpbp4 (Crfg, Nog1) |
Protein name |
GTP-binding protein 4 |
Names |
Chronic renal failure gene protein, GTP-binding protein NGB, Nucleolar GTP-binding protein 1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:69237 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q99ME9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q99ME9-F1 | Predicted | AlphaFoldDB |
34 variants for Q99ME9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389227271 | 6 | F>Y | No | EVA | |
| rs248116203 | 17 | D>E | No | EVA | |
| rs3389235736 | 38 | Y>C | No | EVA | |
| rs3389279464 | 43 | I>V | No | EVA | |
| rs3389268421 | 46 | F>L | No | EVA | |
| rs3389284380 | 55 | Q>H | No | EVA | |
| rs3389270913 | 66 | L>M | No | EVA | |
| rs3389267254 | 69 | F>S | No | EVA | |
| rs3389253424 | 71 | K>Q | No | EVA | |
| rs3389263134 | 81 | D>E | No | EVA | |
| rs3389268490 | 122 | S>P | No | EVA | |
| rs3404190285 | 185 | I>* | No | EVA | |
| rs3389260994 | 218 | Q>H | No | EVA | |
| rs3389284384 | 285 | I>N | No | EVA | |
| rs3389253432 | 325 | E>D | No | EVA | |
| rs3389270832 | 333 | T>K | No | EVA | |
| rs3389263102 | 338 | R>* | No | EVA | |
| rs3389227263 | 340 | L>W | No | EVA | |
| rs3403878910 | 349 | K>Q | No | EVA | |
| rs33802766 | 360 | L>M | No | EVA | |
| rs3389269096 | 404 | E>G | No | EVA | |
| rs3389279461 | 425 | K>N | No | EVA | |
| rs3389268444 | 457 | E>K | No | EVA | |
| rs3389261063 | 471 | E>V | No | EVA | |
| rs3389227245 | 475 | E>G | No | EVA | |
| rs3389269155 | 501 | K>R | No | EVA | |
| rs3389284442 | 506 | P>R | No | EVA | |
| rs3389269083 | 511 | T>I | No | EVA | |
| rs3389268427 | 557 | E>* | No | EVA | |
| rs235295941 | 564 | T>I | No | EVA | |
| rs254347500 | 566 | R>L | No | EVA | |
| rs216246758 | 572 | R>K | No | EVA | |
| rs3413127831 | 596 | A>T | No | EVA | |
| rs3389279460 | 628 | A>V | No | EVA |
No associated diseases with Q99ME9
8 regional properties for Q99ME9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Small GTP-binding protein domain | 168 - 330 | IPR005225 |
| domain | GTP binding domain | 171 - 191 | IPR006073-1 |
| domain | GTP binding domain | 192 - 210 | IPR006073-2 |
| domain | GTP binding domain | 219 - 234 | IPR006073-3 |
| domain | Nucleolar GTP-binding protein 1, Rossman-fold domain | 235 - 292 | IPR010674 |
| domain | NOG, C-terminal | 395 - 446 | IPR012973 |
| domain | OBG-type guanine nucleotide-binding (G) domain | 169 - 340 | IPR031167 |
| domain | NOG1, N-terminal helical domain | 6 - 165 | IPR041623 |
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nuclear membrane | Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| perinuclear region of cytoplasm | Cytoplasm situated near, or occurring around, the nucleus. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. |
| preribosome binding | Binding to a preribosome. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
10 GO annotations of biological process
| Name | Definition |
|---|---|
| maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript. |
| negative regulation of cell migration | Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration. |
| negative regulation of cell population proliferation | Any process that stops, prevents or reduces the rate or extent of cell proliferation. |
| negative regulation of cell-cell adhesion | Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell. |
| negative regulation of collagen binding | Any process that stops, prevents, or reduces the frequency, rate or extent of collagen binding. |
| negative regulation of DNA replication | Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication. |
| negative regulation of protein ubiquitination | Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein. |
| protein stabilization | Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation. |
| regulation of cyclin-dependent protein serine/threonine kinase activity | Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity. |
| ribosomal large subunit biogenesis | A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q02892 | NOG1 | Nucleolar GTP-binding protein 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q9V411 | Non1 | Nucleolar GTP-binding protein 1 | Drosophila melanogaster (Fruit fly) | PR |
| Q9BZE4 | GTPBP4 | GTP-binding protein 4 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAHYNFKKIT | VVPSAKDFID | LTLSKTQRKT | PTVIHKHYQI | HRIRHFYMRK | VKFTQQNYHD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RLSQILSDFP | KLDDIHPFYA | DLMNILYDKD | HYKLALGQIN | IAKNLVDNVA | KDYVRLMKYG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DSLYRCKQLK | RAALGRMCTI | IKRQRQSLEY | LEQVRQHLSR | LPTIDPNTRT | LLLCGYPNVG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KSSFINKVTR | ADVDVQPYAF | TTKSLFVGHM | DYKYLRWQVV | DTPGILDHPL | EDRNTIEMQA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ITALAHLRAA | VLYVMDLSEQ | CGHGLKEQLE | LFQNIRPLFI | NKPLIVVANK | CDVKRIAELS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EEDQKIFLDL | QAEGFPVIET | STLTEEGVIQ | VKTEACDRLL | AHRVETKMKG | NKVNEVLNRL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| HLAVPNKRDD | KERPPFIPEG | VIARRKRMEI | EEPKKKRERD | LELEMGDDYI | LDLQKYWDLM |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NSSEKYDKIP | EIWEGHNVAD | YIDPAIMKKL | EELEKEEELR | TAAGEYDSDS | ESEDEEMMEI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| RQLAKQIREK | KKLKILQSKE | KNKQGPRMPR | TAKKVQRADL | ENEMRSLGVD | MDDKNNAHYA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VQARRSRSVT | RKRKREESVP | PSSTARSRSC | SRTPRDVSGL | RDVKMVKKAK | TMMKKAQKKM |
| 610 | 620 | 630 | |||
| NRLGKKGEAD | RHVFDMKPKH | LLSGKRKAGK | KDRR |