Q02892

PR
Gene name
NOG1 (YPL093W, LPG15W)
Protein name
Nucleolar GTP-binding protein 1
Names
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YPL093W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

324-397 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

45 structures for Q02892

Entry ID Method Resolution Chain Position Source
3JCT EM 308 A b 1-647 PDB
4V7F EM 870 A o 1-647 PDB
5JCS EM 950 A o 1-647 PDB
6C0F EM 370 A W 1-647 PDB
6ELZ EM 330 A b 1-647 PDB
6EM1 EM 360 A b 1-647 PDB
6EM5 EM 430 A b 1-647 PDB
6FT6 EM 390 A b 1-647 PDB
6M62 EM 320 A b 1-647 PDB
6N8J EM 350 A b 1-647 PDB
6N8K EM 360 A b 1-647 PDB
6N8L EM 360 A b 1-647 PDB
6YLG EM 300 A b 1-647 PDB
6YLH EM 310 A b 1-647 PDB
6YLX EM 390 A b 1-647 PDB
6YLY EM 380 A b 1-647 PDB
7BT6 EM 312 A b 1-647 PDB
7BTB EM 322 A b 1-647 PDB
7NAC EM 304 A b 1-647 PDB
7NAD EM 304 A b 1-647 PDB
7NAF EM 313 A b 20-59 PDB
7OF1 EM 310 A b 1-647 PDB
7OH3 EM 340 A b 1-647 PDB
7OHP EM 390 A b 1-647 PDB
7OHQ EM 310 A b 1-647 PDB
7OHR EM 472 A b 1-647 PDB
7OHS EM 438 A b 1-647 PDB
7OHT EM 470 A b 1-647 PDB
7OHU EM 370 A b 1-647 PDB
7OHV EM 390 A b 1-647 PDB
7OHW EM 350 A b 1-647 PDB
7OHX EM 330 A b 1-647 PDB
7OHY EM 390 A b 1-647 PDB
7R72 EM 307 A b 1-647 PDB
7R7A EM 304 A b 1-647 PDB
7R7C EM 371 A b 92-142 PDB
7U0H EM 276 A b 1-647 PDB
7UG6 EM 290 A b 1-647 PDB
7UOO EM 234 A b 1-647 PDB
7UQB EM 243 A b 1-647 PDB
7UQZ EM 244 A b 1-647 PDB
7V08 EM 236 A b 1-647 PDB
7Z34 EM 380 A b 1-647 PDB
8HFR EM 264 A rA 1-647 PDB
AF-Q02892-F1 Predicted AlphaFoldDB

3 variants for Q02892

Variant ID(s) Position Change Description Diseaes Association Provenance
s16-371911 313 P>A No SGRP
s16-371911 313 P>S No SGRP
s16-372088 372 V>I No SGRP

No associated diseases with Q02892

7 regional properties for Q02892

Type Name Position InterPro Accession
domain GTP binding domain 170 - 190 IPR006073-1
domain GTP binding domain 191 - 209 IPR006073-2
domain GTP binding domain 218 - 233 IPR006073-3
domain Nucleolar GTP-binding protein 1, Rossman-fold domain 234 - 291 IPR010674
domain NOG, C-terminal 396 - 449 IPR012973
domain OBG-type guanine nucleotide-binding (G) domain 168 - 340 IPR031167
domain NOG1, N-terminal helical domain 6 - 164 IPR041623

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
preribosome, large subunit precursor A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit.

3 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
RNA binding Binding to an RNA molecule or a portion thereof.

4 GO annotations of biological process

Name Definition
assembly of large subunit precursor of preribosome The aggregation, arrangement and bonding together of a set of components to form the large subunit precursor of the preribosome.
ribosomal large subunit biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis.
ribosomal subunit export from nucleus The directed movement of a ribosomal subunit from the nucleus into the cytoplasm.
rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9V411 Non1 Nucleolar GTP-binding protein 1 Drosophila melanogaster (Fruit fly) PR
Q9BZE4 GTPBP4 GTP-binding protein 4 Homo sapiens (Human) PR
Q99ME9 Gtpbp4 GTP-binding protein 4 Mus musculus (Mouse) PR
10 20 30 40 50 60
MQLSWKDIPT VAPANDLLDI VLNRTQRKTP TVIRPGFKIT RIRAFYMRKV KYTGEGFVEK
70 80 90 100 110 120
FEDILKGFPN INDVHPFHRD LMDTLYEKNH YKISLAAISR AKSLVEQVAR DYVRLLKFGQ
130 140 150 160 170 180
SLFQCKQLKR AALGRMATIV KKLRDPLAYL EQVRQHIGRL PSIDPNTRTL LICGYPNVGK
190 200 210 220 230 240
SSFLRCITKS DVDVQPYAFT TKSLYVGHFD YKYLRFQAID TPGILDRPTE EMNNIEMQSI
250 260 270 280 290 300
YAIAHLRSCV LYFMDLSEQC GFTIEAQVKL FHSIKPLFAN KSVMVVINKT DIIRPEDLDE
310 320 330 340 350 360
ERAQLLESVK EVPGVEIMTS SCQLEENVME VRNKACEKLL ASRIENKLKS QSRINNVLNK
370 380 390 400 410 420
IHVAQPQARD DVKRTPFIPE SVKNLKKYDP EDPNRRKLAR DIEAENGGAG VFNVNLKDKY
430 440 450 460 470 480
LLEDDEWKND IMPEILDGKN VYDFLDPEIA AKLQALEEEE EKLENEGFYN SDDEEEIYDG
490 500 510 520 530 540
FEASEVDDIK EKAAWIRNRQ KTMIAEARNR KSLKNKAIMP RSKLTKSFGK MEEHMSTLGH
550 560 570 580 590 600
DMSALQDKQN RAARKNRYVE RGSDVVFGDQ DALTASTENG VKLRQTDRLL DGVADGSMRS
610 620 630 640
KADRMAKMER RERNRHAKQG ESDRHNAVSL SKHLFSGKRG VGKTDFR