Q99LZ3
Gene name |
Gins4 (Sld5) |
Protein name |
DNA replication complex GINS protein SLD5 |
Names |
GINS complex subunit 4 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:109145 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q99LZ3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q99LZ3-F1 | Predicted | AlphaFoldDB |
12 variants for Q99LZ3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388973218 | 3 | E>V | No | EVA | |
| rs224253477 | 4 | V>I | No | EVA | |
| rs3388976810 | 21 | L>V | No | EVA | |
| rs3388973208 | 29 | K>* | No | EVA | |
| rs3388929158 | 43 | L>P | No | EVA | |
| rs3388973126 | 55 | M>K | No | EVA | |
| rs3388981230 | 64 | N>I | No | EVA | |
| rs3388981253 | 87 | Y>* | No | EVA | |
| rs3388976283 | 102 | K>* | No | EVA | |
| rs246901007 | 115 | S>T | No | EVA | |
| rs224577059 | 137 | T>M | No | EVA | |
| rs3388981320 | 174 | R>G | No | EVA |
No associated diseases with Q99LZ3
No regional properties for Q99LZ3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q99LZ3 | |||
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| CMG complex | A protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| GINS complex | A heterotetrameric protein complex that associates with replication origins, where it is required for the initiation of DNA replication, and with replication forks. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA unwinding involved in DNA replication | The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication. |
| double-strand break repair via break-induced replication | The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome. |
| inner cell mass cell proliferation | The proliferation of cells in the inner cell mass. |
| positive regulation of DNA primase activity | Any process that activates or increases the frequency, rate or extent of DNA primase activity. |
| positive regulation of DNA-directed DNA polymerase activity | Any process that activates or increases the frequency, rate or extent of DNA-directed DNA polymerase activity. |
3 homologous proteins in AiPD
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTEVLDLHGQ | DSDGGSEEMV | LTPAELIEKL | EQAWMNEKFA | PELLESKAEI | VECVMEQLEH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| MEENLRRAKK | GDLKVSIHRM | EMERIRYVLS | SYLRCRLMKI | EKFFPHILEK | EKVRSEGEPS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SLSPEEFVFA | KEYMDHTETH | FKNVALKHMP | PNLQKVDLLR | AVPKPDLDSY | VFLRVKERQE |
| 190 | 200 | 210 | 220 | ||
| NILVEPEADE | QRDYVIDLEV | GSQHLIRYKT | IAPLVASGAV | QLI |