Q499W2

PR
Gene name
Gins4 (Sld5)
Protein name
DNA replication complex GINS protein SLD5
Names
GINS complex subunit 4
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:290842
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-52 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q499W2

Entry ID Method Resolution Chain Position Source
AF-Q499W2-F1 Predicted AlphaFoldDB

No variants for Q499W2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q499W2

No associated diseases with Q499W2

3 regional properties for Q499W2

Type Name Position InterPro Accession
domain GINS subunit, domain A 34 - 126 IPR021151
domain DNA replication complex GINS protein SLD5, C-terminal 165 - 223 IPR031633
domain GINS complex protein Sld5, alpha-helical domain 26 - 146 IPR038749

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Chromosome
  • Associates with chromatin
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
CMG complex A protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
GINS complex A heterotetrameric protein complex that associates with replication origins, where it is required for the initiation of DNA replication, and with replication forks.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

5 GO annotations of biological process

Name Definition
DNA unwinding involved in DNA replication The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication.
double-strand break repair via break-induced replication The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome.
inner cell mass cell proliferation The proliferation of cells in the inner cell mass.
positive regulation of DNA primase activity Any process that activates or increases the frequency, rate or extent of DNA primase activity.
positive regulation of DNA-directed DNA polymerase activity Any process that activates or increases the frequency, rate or extent of DNA-directed DNA polymerase activity.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A2VE40 GINS4 DNA replication complex GINS protein SLD5 Bos taurus (Bovine) PR
Q9BRT9 GINS4 DNA replication complex GINS protein SLD5 Homo sapiens (Human) PR
Q99LZ3 Gins4 DNA replication complex GINS protein SLD5 Mus musculus (Mouse) PR
10 20 30 40 50 60
MTEVQDLHGQ DSDEGSEEVV LTPAELIERL EQAWMNEKFA PELLESKSEI VECVMEQLEH
70 80 90 100 110 120
MEENLRRAKK GDLKVSIHRM EMERIRYVLS SYLRCRLMKI EKFFPHILEK EKTRPAGEPS
130 140 150 160 170 180
SLSPEEFVFA KEYMDHTETH FKNVALKHMP PNLQKVDLMR AVPKPDLDSY VFLRVKERQE
190 200 210 220
NILVEPEADE QRDYVIDLEE GSQHLIRYKT IAPLVASGAV QLI