A2VE40
Gene name |
GINS4 (SLD5) |
Protein name |
DNA replication complex GINS protein SLD5 |
Names |
GINS complex subunit 4 |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:616799 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A2VE40
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A2VE40-F1 | Predicted | AlphaFoldDB |
63 variants for A2VE40
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs434661483 | 20 | I>V | No | EVA | |
| rs453932038 | 62 | E>G | No | EVA | |
| rs465863887 | 63 | E>* | No | EVA | |
| rs432912243 | 64 | N>K | No | EVA | |
| rs451181630 | 65 | L>P | No | EVA | |
| rs443220794 | 75 | V>A | No | EVA | |
| rs456638257 | 85 | I>M | No | EVA | |
| rs475118331 | 87 | F>C | No | EVA | |
| rs442127622 | 90 | S>G | No | EVA | |
| rs460626468 | 91 | S>R | No | EVA | |
| rs479141457 | 92 | Y>S | No | EVA | |
| rs439715970 | 93 | L>V | No | EVA | |
| rs483037221 | 96 | R>P | No | EVA | |
| rs458041495 | 96 | R>W | No | EVA | |
| rs450120665 | 98 | M>K | No | EVA | |
| rs456193999 | 100 | I>M | No | EVA | |
| rs474707052 | 101 | E>* | No | EVA | |
| rs441591139 | 101 | E>D | No | EVA | |
| rs453738047 | 102 | K>M | No | EVA | |
| rs473689299 | 102 | K>N | No | EVA | |
| rs453738047 | 102 | K>R | No | EVA | |
| rs453738047 | 102 | K>T | No | EVA | |
| rs440721634 | 104 | F>S | No | EVA | |
| rs477374725 | 106 | H>P | No | EVA | |
| rs444610009 | 107 | T>P | No | EVA | |
| rs444610009 | 107 | T>S | No | EVA | |
| rs462842541 | 108 | L>F | No | EVA | |
| rs448378099 | 109 | E>K | No | EVA | |
| rs478929010 | 111 | E>D | No | EVA | |
| rs467026897 | 111 | E>K | No | EVA | |
| rs467026897 | 111 | E>Q | No | EVA | |
| rs445895934 | 112 | K>N | No | EVA | |
| rs464471833 | 113 | T>P | No | EVA | |
| rs456330996 | 117 | E>Q | No | EVA | |
| rs468267275 | 118 | E>* | No | EVA | |
| rs468267275 | 118 | E>K | No | EVA | |
| rs468267275 | 118 | E>Q | No | EVA | |
| rs435319603 | 119 | P>R | No | EVA | |
| rs472257433 | 125 | E>D | No | EVA | |
| rs453623293 | 125 | E>G | No | EVA | |
| rs439201824 | 126 | E>A | No | EVA | |
| rs439201824 | 126 | E>G | No | EVA | |
| rs518068459 | 127 | L>F | No | EVA | |
| rs452735874 | 127 | L>V | No | EVA | |
| rs471111448 | 128 | V>D | No | EVA | |
| rs481308202 | 129 | F>L | No | EVA | |
| rs463030626 | 129 | F>Y | No | EVA | |
| rs442136664 | 130 | A>S | No | EVA | |
| rs442136664 | 130 | A>T | No | EVA | |
| rs460623822 | 130 | A>V | No | EVA | |
| rs435924303 | 136 | N>D | No | EVA | |
| rs454290661 | 136 | N>S | No | EVA | |
| rs466351844 | 139 | T>P | No | EVA | |
| rs433378778 | 140 | Y>C | No | EVA | |
| rs451788286 | 143 | D>Y | No | EVA | |
| rs461848004 | 148 | H>Y | No | EVA | |
| rs455695080 | 149 | M>I | No | EVA | |
| rs443644980 | 149 | M>L | No | EVA | |
| rs474111726 | 151 | P>S | No | EVA | |
| rs450789241 | 162 | V>D | No | EVA | |
| rs474591797 | 201 | G>C | No | EVA | |
| rs441606000 | 202 | S>L | No | EVA | |
| rs440831634 | 216 | A>T | No | EVA |
No associated diseases with A2VE40
4 regional properties for A2VE40
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) | 223 - 402 | IPR002314 |
| domain | Aminoacyl-tRNA synthetase, class II | 179 - 412 | IPR006195 |
| domain | Serine-tRNA synthetase, type1, N-terminal | 1 - 109 | IPR015866 |
| domain | Serine-tRNA ligase catalytic core domain | 122 - 419 | IPR033729 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| CMG complex | A protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| GINS complex | A heterotetrameric protein complex that associates with replication origins, where it is required for the initiation of DNA replication, and with replication forks. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA unwinding involved in DNA replication | The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication. |
| double-strand break repair via break-induced replication | The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome. |
| inner cell mass cell proliferation | The proliferation of cells in the inner cell mass. |
| positive regulation of DNA primase activity | Any process that activates or increases the frequency, rate or extent of DNA primase activity. |
| positive regulation of DNA-directed DNA polymerase activity | Any process that activates or increases the frequency, rate or extent of DNA-directed DNA polymerase activity. |
3 homologous proteins in AiPD
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAEEADLLGQ | DSDGDSEEVI | LTPAELIDRL | EQAWMNEKFA | PELLENKSEI | VECVMEQLEH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| MEENLKRAKK | GDLKVSIHQM | EMERIRFVLS | SYLRCRLMKI | EKFFPHTLEK | EKTRREEEPP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ILSPEELVFA | KEFLANTETY | LKDTALKHMP | PNLQKVDLLR | TVPKPDLDAY | VFLRVKERQE |
| 190 | 200 | 210 | 220 | ||
| NILVEPENDE | QRDYVIDLEE | GSQHLMRYRT | VAPLVASGAI | QLI |