Q99LI7

PR
Gene name
Cstf3
Protein name
Cleavage stimulation factor subunit 3
Names
CF-1 77 kDa subunit, Cleavage stimulation factor 77 kDa subunit, CSTF 77 kDa subunit, CstF-77
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:228410
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-55 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for Q99LI7

Entry ID Method Resolution Chain Position Source
2OND X-ray 280 A A/B 242-549 PDB
2OOE X-ray 300 A A 21-549 PDB
AF-Q99LI7-F1 Predicted AlphaFoldDB

35 variants for Q99LI7

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3391712618 18 V>G No EVA
rs3388577896 90 R>K No EVA
rs3388576129 113 G>D No EVA
rs1132002718 143 W>R No EVA
rs1132885940 161 E>* No EVA
rs1131699577 181 I>F No EVA
rs1134382313 181 I>S No EVA
rs1135261183 184 E>K No EVA
rs3388570879 263 P>S No EVA
rs3388562937 274 K>Q No EVA
rs3388574007 283 C>S No EVA
rs3388577892 301 L>M No EVA
rs3388569366 310 E>V No EVA
rs3388570802 326 N>I No EVA
rs3388569133 327 I>N No EVA
rs3388569133 327 I>S No EVA
rs3388574482 334 T>R No EVA
rs3388569356 346 Y>C No EVA
rs3388570866 369 I>F No EVA
rs3388569399 409 H>Q No EVA
rs3388575316 462 N>Y No EVA
rs3388577868 501 I>K No EVA
rs3388577778 501 I>V No EVA
rs3388574269 559 P>T No EVA
rs3388575066 570 V>F No EVA
rs3388575264 574 E>* No EVA
rs3388568345 597 L>I No EVA
rs3388577928 623 L>P No EVA
rs3388574021 641 E>G No EVA
rs3388569082 649 P>S No EVA
rs3388574528 656 V>E No EVA
rs3388577875 663 A>T No EVA
rs3388568306 663 A>V No EVA
rs3391857352 701 V>A No EVA
rs3388570831 703 P>S No EVA

No associated diseases with Q99LI7

11 regional properties for Q99LI7

Type Name Position InterPro Accession
repeat HAT (Half-A-TPR) repeat 45 - 77 IPR003107-1
repeat HAT (Half-A-TPR) repeat 79 - 110 IPR003107-2
repeat HAT (Half-A-TPR) repeat 117 - 152 IPR003107-3
repeat HAT (Half-A-TPR) repeat 163 - 196 IPR003107-4
repeat HAT (Half-A-TPR) repeat 229 - 261 IPR003107-5
repeat HAT (Half-A-TPR) repeat 271 - 303 IPR003107-6
repeat HAT (Half-A-TPR) repeat 319 - 352 IPR003107-7
repeat HAT (Half-A-TPR) repeat 354 - 387 IPR003107-8
repeat HAT (Half-A-TPR) repeat 424 - 456 IPR003107-9
repeat HAT (Half-A-TPR) repeat 458 - 494 IPR003107-10
domain Suppressor of forked 375 - 649 IPR008847

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name Definition
mRNA binding Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.

2 GO annotations of biological process

Name Definition
mRNA 3'-end processing Any process involved in forming the mature 3' end of an mRNA molecule.
RNA 3'-end processing Any process involved in forming the mature 3' end of an RNA molecule.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P25298 RNA14 mRNA 3'-end-processing protein RNA14 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q12996 CSTF3 Cleavage stimulation factor subunit 3 Homo sapiens (Human) PR
10 20 30 40 50 60
MSGDAAAEQA AEYVPEKVKK AEKKLEENPY DLDAWSILIR EAQNQPIDKA RKTYERLVAQ
70 80 90 100 110 120
FPSSGRFWKL YIEAEIKAKN YDKVEKLFQR CLMKVLHIDL WKCYLSYVRE TKGKLPSYKE
130 140 150 160 170 180
KMAQAYDFAL DKIGMEIMSY QIWVDYINFL KGVEAVGSYA ENQRITAVRR VYQRGCVNPM
190 200 210 220 230 240
INIEQLWRDY NKYEEGINIH LAKKMIEDRS RDYMNARRVA KEYETVMKGL DRNAPSVPPQ
250 260 270 280 290 300
NTPQEAQQVD MWKKYIQWEK SNPLRTEDQT LITKRVMFAY EQCLLVLGHH PDIWYEAAQY
310 320 330 340 350 360
LEQSSKLLAE KGDMNNAKLF SDEAANIYER AISTLLKKNM LLYFAYADYE ESRMKYEKVH
370 380 390 400 410 420
SIYNRLLAIE DIDPTLVYIQ YMKFARRAEG IKSGRMIFKK AREDARTRHH VYVTAALMEY
430 440 450 460 470 480
YCSKDKSVAF KIFELGLKKY GDIPEYVLAY IDYLSHLNED NNTRVLFERV LTSGSLPPEK
490 500 510 520 530 540
SGEIWARFLA FESNIGDLAS ILKVEKRRFT AFREEYEGKE TALLVDRYKF MDLYPCSASE
550 560 570 580 590 600
LKALGYKDVS RAKLAAIIPD PVVAPSIVPV LKDEVDRKPE YPKPDTQQMI PFQPRHLAPP
610 620 630 640 650 660
GLHPVPGGVF PVPPAAVVLM KLLPPPICFQ GPFVQVDELM EIFRRCKIPN TVEEAVRIIT
670 680 690 700 710
GGAPELAVEG NGPVESSAVL TKAVKRPNED SDEDEEKGAV VPPVHDIYRA RQQKRIR