P25298
Gene name |
RNA14 (YMR061W, YM9796.14) |
Protein name |
mRNA 3'-end-processing protein RNA14 |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YMR061W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for P25298
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2L9B | NMR | - | B | 626-677 | PDB |
| AF-P25298-F1 | Predicted | AlphaFoldDB |
17 variants for P25298
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s13-392929 | 59 | A>D | No | SGRP | |
| s13-393280 | 176 | K>R | No | SGRP | |
| s13-393598 | 282 | N>S | No | SGRP | |
| s13-393663 | 304 | S>C | No | SGRP | |
| s13-393664 | 304 | S>I | No | SGRP | |
| s13-393787 | 345 | N>I | No | SGRP | |
| s13-393826 | 358 | C>Y | No | SGRP | |
| s13-393855 | 368 | V>I | No | SGRP | |
| s13-393872 | 373 | D>E | No | SGRP | |
| s13-393925 | 391 | N>I | No | SGRP | |
| s13-394086 | 445 | I>V | No | SGRP | |
| s13-394302 | 517 | T>A | No | SGRP | |
| s13-394407 | 552 | Q>K | No | SGRP | |
| s13-394501 | 583 | E>G | No | SGRP | |
| s13-394540 | 596 | H>R | No | SGRP | |
| s13-394600 | 616 | N>S | No | SGRP | |
| s13-394662 | 637 | D>N | No | SGRP |
No associated diseases with P25298
10 regional properties for P25298
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | HAT (Half-A-TPR) repeat | 56 - 88 | IPR003107-1 |
| repeat | HAT (Half-A-TPR) repeat | 90 - 124 | IPR003107-2 |
| repeat | HAT (Half-A-TPR) repeat | 134 - 170 | IPR003107-3 |
| repeat | HAT (Half-A-TPR) repeat | 181 - 214 | IPR003107-4 |
| repeat | HAT (Half-A-TPR) repeat | 251 - 289 | IPR003107-5 |
| repeat | HAT (Half-A-TPR) repeat | 298 - 330 | IPR003107-6 |
| repeat | HAT (Half-A-TPR) repeat | 463 - 495 | IPR003107-7 |
| repeat | HAT (Half-A-TPR) repeat | 497 - 532 | IPR003107-8 |
| domain | Suppressor of forked | 413 - 596 | IPR008847-1 |
| domain | Suppressor of forked | 598 - 669 | IPR008847-2 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| mRNA cleavage factor complex | Any macromolecular complex involved in cleavage or polyadenylation of mRNA molecules. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| mRNA polyadenylation | The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript. |
| pre-mRNA cleavage required for polyadenylation | The targeted, endonucleolytic cleavage of a pre-mRNA, required for polyadenylation of the 3' end. This cleavage is directed by binding sites near the 3' end of the mRNA and leaves a 3' hydoxyl end which then becomes a target for adenylation. |
| response to DNA damage checkpoint signaling | A process that occurs in response to signals generated as a result of DNA damage checkpoint signaling. |
| RNA 3'-end processing | Any process involved in forming the mature 3' end of an RNA molecule. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSSTTPDLL | YPSADKVAEP | SDNIHGDELR | LRERIKDNPT | NILSYFQLIQ | YLETQESYAK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VREVYEQFHN | TFPFYSPAWT | LQLKGELARD | EFETVEKILA | QCLSGKLENN | DLSLWSTYLD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YIRRKNNLIT | GGQEARAVIV | KAFQLVMQKC | AIFEPKSSSF | WNEYLNFLEQ | WKPFNKWEEQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QRIDMLREFY | KKMLCVPFDN | LEKMWNRYTQ | WEQEINSLTA | RKFIGELSAE | YMKARSLYQE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| WLNVTNGLKR | ASPINLRTAN | KKNIPQPGTS | DSNIQQLQIW | LNWIKWEREN | KLMLSEDMLS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QRISYVYKQG | IQYMIFSAEM | WYDYSMYISE | NSDRQNILYT | ALLANPDSPS | LTFKLSECYE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LDNDSESVSN | CFDKCTQTLL | SQYKKIASDV | NSGEDNNTEY | EQELLYKQRE | KLTFVFCVYM |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NTMKRISGLS | AARTVFGKCR | KLKRILTHDV | YVENAYLEFQ | NQNDYKTAFK | VLELGLKYFQ |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NDGVYINKYL | DFLIFLNKDS | QIKTLFETSV | EKVQDLTQLK | EIYKKMISYE | SKFGNLNNVY |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SLEKRFFERF | PQENLIEVFT | SRYQIQNSNL | IKKLELTYMY | NEEEDSYFSS | GNGDGHHGSY |
| 610 | 620 | 630 | 640 | 650 | 660 |
| NMSSSDRKRL | MEETGNNGNF | SNKKFKRDSE | LPTEVLDLLS | VIPKRQYFNT | NLLDAQKLVN |
| 670 | |||||
| FLNDQVEIPT | VESTKSG |