AiPD: Autoinhibited Protein Database

Q12996

Gene name	CSTF3
Protein name	Cleavage stimulation factor subunit 3
Names	CF-1 77 kDa subunit, Cleavage stimulation factor 77 kDa subunit, CSTF 77 kDa subunit, CstF-77
Species	Homo sapiens (Human)
KEGG Pathway	hsa:1479
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-55 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-55 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

4 structures for Q12996

Entry ID	Method	Resolution	Chain	Position	Source
6B3X	X-ray	230 A	B	581-600	PDB
6URO	EM	360 A	E/F	1-717	PDB
7ZY4	X-ray	255 A	A/B	241-549	PDB
AF-Q12996-F1	Predicted				AlphaFoldDB

240 variants for Q12996

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA380004544 rs1457070110	4	D>N		No	ClinGen gnomAD
CA380004536 rs1258117306	5	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA380004519 rs1320616744	7	T>M		No	ClinGen TOPMed gnomAD
CA380004524 rs1202764648	7	T>P		No	ClinGen TOPMed gnomAD
rs543353295 CA219562684	9	Q>P		No	ClinGen Ensembl
CA380000302 rs1173190902	11	A>D		No	ClinGen gnomAD
rs1023167813 CA219556544 COSM1353588 COSM1353589	23	K>N	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated Ensembl NCI-TCGA
TCGA novel	25	L>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA219556536 rs201161735	29	P>L		No	ClinGen 1000Genomes
rs146141311 CA5938262	29	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	34	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1198017824 CA380000121	36	S>N		No	ClinGen gnomAD
TCGA novel	40	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs770748628 CA5938244	44	N>S		No	ClinGen ExAC gnomAD
rs988931195 CA380000035	45	Q>H		No	ClinGen TOPMed gnomAD
rs1351261106 CA380000024	47	I>T		No	ClinGen TOPMed gnomAD
CA380000028 rs1212682297	47	I>V		No	ClinGen TOPMed gnomAD
CA379999997 rs1240382013	51	R>Q		No	ClinGen TOPMed gnomAD
rs1459100494 CA379999998	51	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA5938242 rs773179561	52	K>N		No	ClinGen ExAC gnomAD
CA5938239 rs370295642	56	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
TCGA novel	57	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs754549742 CA5938238	59	A>V		No	ClinGen ExAC TOPMed gnomAD
CA379999862 rs1314038304	60	Q>E		No	ClinGen TOPMed gnomAD
CA5938237 rs143051189	60	Q>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA379999829 rs1395490636	61	F>L		No	ClinGen TOPMed
rs750862039 CA5938234	62	P>L		No	ClinGen ExAC gnomAD
rs758817866 CA5938235	62	P>S		No	ClinGen ExAC gnomAD
rs1590283283 CA379999648	71	Y>C		No	ClinGen Ensembl
TCGA novel	71	Y>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA379999639 rs1258076169	72	I>L		No	ClinGen gnomAD
rs1283898276 CA379999628	72	I>T		No	ClinGen TOPMed gnomAD
CA379999585 rs1487290549	75	E>K		No	ClinGen gnomAD
rs1476249663 CA379992956	77	K>N		No	ClinGen gnomAD
CA219542311 rs868525397	82	D>G		No	ClinGen Ensembl
TCGA novel	84	V>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1171706910 CA379992620	98	I>L		No	ClinGen gnomAD
TCGA novel	101	W>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs976474876 CA219542115	101	W>R		No	ClinGen Ensembl
TCGA novel	101	W>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1200287359 CA379992492	103	C>G		No	ClinGen TOPMed
TCGA novel	103	C>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs908175246 CA219542100	104	Y>N		No	ClinGen Ensembl
TCGA novel	109	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM926465 rs369649984 CA219542099	111	T>A	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP NCI-TCGA TOPMed
TCGA novel	111	T>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	113	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs748517458 CA5938170	120	E>G		No	ClinGen ExAC gnomAD
CA379991344 rs1214985238	121	K>E		No	ClinGen gnomAD
TCGA novel	122	M>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1311277773 CA379991290	124	Q>E		No	ClinGen TOPMed
rs1565006205 CA379991125	133	I>T		No	ClinGen Ensembl
rs1225487009 CA379991030	139	S>F		No	ClinGen gnomAD
CA379991036 rs1285231074	139	S>T		No	ClinGen gnomAD
rs138450714 CA5938168	140	Y>H		No	ClinGen ESP ExAC gnomAD
CA219540768 rs371469100	145	D>E		No	ClinGen ESP TOPMed
CA5938155 rs770453717	148	N>S		No	ClinGen ExAC TOPMed gnomAD
CA379990730 rs1372237103	159	Y>F		No	ClinGen TOPMed gnomAD
rs1169458534 CA379990671	163	Q>H		No	ClinGen gnomAD
CA5938139 rs752507894	169	R>*		No	ClinGen ExAC gnomAD
CA219540585 rs928271515	171	V>I		No	ClinGen Ensembl
rs767308681 CA5938138	174	R>*		No	ClinGen ExAC TOPMed gnomAD
CA5938135 rs765989081	181	I>F		No	ClinGen ExAC gnomAD
rs762422604 CA5938134	183	I>T		No	ClinGen ExAC gnomAD
rs1308025687 CA379990141	191	N>S		No	ClinGen gnomAD
CA379990108 rs765732601	192	K>N		No	ClinGen ExAC TOPMed gnomAD
CA379989695 rs1391533502	197	I>V		No	ClinGen gnomAD
rs1300471016	205	M>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1300471016	205	M>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1275883494 CA379989295	219	V>I		No	ClinGen TOPMed gnomAD
rs935184836 CA219539032	220	A>P		No	ClinGen Ensembl
TCGA novel	222	E>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA380003618 rs1487102470	222	E>D		No	ClinGen gnomAD
rs1444389661 CA380003580	227	M>I		No	ClinGen TOPMed
rs1240203239 CA380003540	233	N>S		No	ClinGen TOPMed
rs761178670 CA5938106	236	S>L		No	ClinGen ExAC gnomAD
rs775992303 CA380003512	238	P>A		No	ClinGen ExAC gnomAD
rs775992303 CA5938105	238	P>S		No	ClinGen ExAC gnomAD
CA380003406 rs1425693457	252	W>C		No	ClinGen TOPMed
CA5938103 rs746111488	256	I>V		No	ClinGen ExAC gnomAD
TCGA novel	261	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA380003328 rs1474802559	262	N>I		No	ClinGen gnomAD
CA219553729 rs1048998468	263	P>A		No	ClinGen TOPMed
CA380003275 rs1418573446	270	T>N		No	ClinGen gnomAD
rs756022140 CA219553726	272	I>K		No	ClinGen Ensembl
CA380003216 rs1327439999	277	M>T		No	ClinGen TOPMed
rs1397709098 CA380003181	282	Q>E		No	ClinGen TOPMed
rs1565004330 CA380003154	286	V>M		No	ClinGen Ensembl
CA380003147 rs1040714477	287	L>V		No	ClinGen gnomAD
CA380003133 rs1228699551	289	H>R		No	ClinGen gnomAD
rs1174898698 CA380003103	293	I>T		No	ClinGen gnomAD
CA380003087 rs1309471424	295	Y>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs970654610 CA219552943	297	A>D		No	ClinGen TOPMed
CA5938085 rs774678370	299	Q>R		No	ClinGen ExAC gnomAD
CA5938083 rs763082197	305	S>C		No	ClinGen ExAC gnomAD
CA380002994 rs769799632	309	A>S		No	ClinGen ExAC gnomAD
CA5938081 rs769799632	309	A>T		No	ClinGen ExAC gnomAD
rs773366714 CA5938057	314	M>I		No	ClinGen ExAC gnomAD
CA380002818 rs1442488198	327	I>V		No	ClinGen gnomAD
rs1455824124 CA380002769	331	A>S		No	ClinGen TOPMed
CA380002770 rs1455824124	331	A>T		No	ClinGen TOPMed
CA219552710 rs1008165952	336	L>S		No	ClinGen TOPMed
rs775545700 CA5938054	346	Y>C		No	ClinGen ExAC gnomAD
CA380002596 rs1363702632	346	Y>H		No	ClinGen TOPMed
CA380002579 rs1160364098	347	A>V		No	ClinGen TOPMed
TCGA novel	348	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5938035 rs184046143	352	S>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs761937370 CA5938034	352	S>R		No	ClinGen ExAC gnomAD
rs1213854449 CA380002475	353	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1284968775 CA380002406	358	K>N		No	ClinGen gnomAD
rs776567292 CA5938033	361	S>G		No	ClinGen ExAC gnomAD
rs1022053463 CA219552528	361	S>N		No	ClinGen gnomAD
CA219552525 rs181095002	362	I>V		No	ClinGen 1000Genomes TOPMed
CA380002358 rs1272523811	363	Y>C		No	ClinGen TOPMed gnomAD
rs764167058 CA5938032	364	N>D		No	ClinGen ExAC gnomAD
CA219552513 rs200350025	367	L>V		No	ClinGen gnomAD
rs953610086 CA219552486	369	I>F		No	ClinGen Ensembl
CA380002232 rs1458908357	375	T>I		No	ClinGen gnomAD
CA380001803 rs1352188784	380	Q>E		No	ClinGen gnomAD
CA380001762 rs1208092891	385	A>S		No	ClinGen gnomAD
CA5938011 rs760765425	392	K>R		No	ClinGen ExAC gnomAD
rs774193413 CA5938010	397	I>V		No	ClinGen ExAC gnomAD
rs1452834277 CA380001668	399	K>*		No	ClinGen gnomAD
CA380001629 rs1449278647	404	D>G		No	ClinGen TOPMed
rs1169750503 CA380001622	405	T>N		No	ClinGen TOPMed
rs1590264224 CA380001625	405	T>P		No	ClinGen Ensembl
rs74989023 CA219551734	406	R>K		No	ClinGen Ensembl
rs1590264218 CA380001613	407	T>P		No	ClinGen Ensembl
rs773139989 CA5938006	408	R>C		No	ClinGen ExAC TOPMed gnomAD
COSM2114923 CA5938005 rs11553357	408	R>H	Variant assessed as Somatic; 0.0 impact. pancreas haematopoietic_and_lymphoid_tissue [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA380001593 rs1203529211	410	H>Y		No	ClinGen gnomAD
CA380001587 rs1312426530	411	V>I		No	ClinGen TOPMed
CA5938004 rs747773840	414	T>S		No	ClinGen ExAC TOPMed gnomAD
CA5938003 rs561886549	420	Y>*		No	ClinGen 1000Genomes ExAC gnomAD
CA5937989 rs762991154	434	E>*		No	ClinGen ExAC gnomAD
TCGA novel	438	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA380001360 rs1184901333	441	G>E		No	ClinGen Ensembl
CA5937988 rs750331923	442	D>N		No	ClinGen ExAC gnomAD
rs1314575981 CA380001328	446	Y>H		No	ClinGen gnomAD
CA380001313 rs1165865259	448	L>Q		No	ClinGen gnomAD
rs776188354 CA5937985	451	I>T		No	ClinGen ExAC TOPMed gnomAD
rs1416024472 COSM3670754 CA380001295	451	I>V	Variant assessed as Somatic; impact. prostate [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA5937984 rs768333946	452	D>V		No	ClinGen ExAC gnomAD
CA380001282 rs1413382563	453	Y>H		No	ClinGen gnomAD
rs1384260400 CA380001261	456	H>Y		No	ClinGen gnomAD
rs1467799122 CA380001246	458	N>S		No	ClinGen gnomAD
rs773633893	459	E>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA219549858 rs987209279	461	N>T		No	ClinGen TOPMed
CA5937954 rs769999645	464	R>*		No	ClinGen ExAC gnomAD
CA5937953 rs748406781	467	F>S		No	ClinGen ExAC gnomAD
CA219549847 rs571388005	469	R>*		No	ClinGen TOPMed gnomAD
TCGA novel	473	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA380000825 rs1230808210	477	P>R		No	ClinGen gnomAD
CA380000765 rs1284664862	484	I>T		No	ClinGen TOPMed
rs1318561833 CA380000759	485	W>*		No	ClinGen TOPMed
CA380000746 rs1294592384	487	R>*		No	ClinGen gnomAD
rs765742783 CA5937939	487	R>Q		No	ClinGen ExAC gnomAD
rs768987291 CA5937933	508	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs865805106 CA219549154	518	G>V		No	ClinGen Ensembl
CA219549144 rs868690281	525	V>L		No	ClinGen Ensembl
rs768459848 CA219549129	530	F>L		No	ClinGen Ensembl
CA5937925 rs755947614	533	L>I		No	ClinGen ExAC TOPMed gnomAD
rs767220700 CA5937923	535	P>T		No	ClinGen ExAC TOPMed gnomAD
CA5937922 rs754627840	537	S>C		No	ClinGen ExAC gnomAD
CA219549114 rs758898746	540	E>K		No	ClinGen Ensembl
TCGA novel	543	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA598410383 rs1230187823	548	D>Y		No	ClinGen gnomAD
rs1283400504 CA379999958	549	V>G		No	ClinGen gnomAD
CA379999947 rs1448222905	550	S>F		No	ClinGen gnomAD
CA379999942 rs1315598913	551	R>C		No	ClinGen gnomAD
rs769717692 CA5937905	554	L>V		No	ClinGen ExAC gnomAD
rs910314397 CA219547632	557	I>V		No	ClinGen TOPMed gnomAD
rs748010913 CA5937904 COSM3719377	559	P>L	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA379999867 rs1266419939	559	P>S		No	ClinGen gnomAD
rs754720144 CA5937902	562	V>A		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	566	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs745985559 CA5937901	567	I>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	569	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA379999758 rs756792158	571	L>M		No	ClinGen TOPMed gnomAD
CA219547599 rs756792158	571	L>V		No	ClinGen TOPMed gnomAD
CA5937898 rs749891940	577	R>G		No	ClinGen ExAC gnomAD
CA379999689 rs1288874012	577	R>K		No	ClinGen gnomAD
rs1288874012 CA379999688	577	R>T		No	ClinGen gnomAD
rs1590259768 CA379999674	578	K>N		No	ClinGen Ensembl
CA379999670 rs1590259766	579	P>T		No	ClinGen Ensembl
rs765914953 CA5937897	580	E>G		No	ClinGen ExAC gnomAD
CA5937896 rs762417208	581	Y>S		No	ClinGen ExAC gnomAD
CA379999627 rs1165256478	582	P>L		No	ClinGen TOPMed
rs754345078 CA5937895	583	K>N		No	ClinGen ExAC gnomAD
CA5937894 rs764581305	584	P>S		No	ClinGen ExAC gnomAD
rs760913649 CA5937893	587	Q>E		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	588	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5937892 rs775825908	591	P>Q		No	ClinGen ExAC gnomAD
rs776599477 CA5937864	602	L>S		No	ClinGen ExAC gnomAD
rs1208057545 CA379999058	603	H>Y		No	ClinGen gnomAD
rs563376018 CA5937862	604	P>S		No	ClinGen 1000Genomes ExAC gnomAD
rs1220252982 CA379999012	607	G>D		No	ClinGen gnomAD
TCGA novel	609	V>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs771844785 COSM428925 CA5937860	614	P>S	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs1409658306 CA379998941	615	A>T		No	ClinGen gnomAD
CA379998922 rs1310047634	617	V>I		No	ClinGen gnomAD
CA5937858 rs778674552	622	L>R		No	ClinGen ExAC gnomAD
rs1007095295 CA219547003	628	C>G		No	ClinGen Ensembl
CA5937855 rs748790656	630	Q>R		No	ClinGen ExAC gnomAD
CA379998640 rs1484586738	637	D>E		No	ClinGen gnomAD
CA5937831 rs755599842	640	M>T		No	ClinGen ExAC gnomAD
rs1465747134 CA379998575	642	I>V		No	ClinGen gnomAD
rs749330202 COSM167907 CA5937830	644	R>Q	large_intestine Variant assessed as Somatic; 4.619e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA379998485 rs1321321104	648	I>M		No	ClinGen gnomAD
rs1223976439 CA379998367	652	V>F		No	ClinGen TOPMed gnomAD
rs1397391220 CA379998309	656	V>A		No	ClinGen TOPMed
CA5937809 rs747673379	657	R>M		No	ClinGen ExAC gnomAD
rs781609088 CA5937808	660	T>I		No	ClinGen ExAC gnomAD
rs769147168 CA5937807	661	G>A		No	ClinGen ExAC gnomAD
CA219546664 rs774690642	661	G>C		No	ClinGen TOPMed gnomAD
rs774690642 CA379998254	661	G>S		No	ClinGen TOPMed gnomAD
CA379998116 rs1369622217	672	G>S		No	ClinGen gnomAD
rs750644457 CA5937803	673	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA5937801 rs757337076	674	V>M	Variant assessed as Somatic; 9.336e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs753943459 CA5937800	679	V>I		No	ClinGen ExAC gnomAD
CA379998002 rs1433126781	681	T>N		No	ClinGen gnomAD
rs1268410444 CA379997990	682	K>R		No	ClinGen TOPMed gnomAD
CA219546617 rs947718358	683	A>S		No	ClinGen gnomAD
rs751491565 CA5937797	684	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1161226423 CA379997930	687	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA5937796 rs551015961	688	N>S		No	ClinGen 1000Genomes ExAC gnomAD
rs1254352690 CA379997868	693	E>A		No	ClinGen gnomAD
CA379997819 rs1331680486	696	E>D		No	ClinGen gnomAD
CA379997806 rs1303114033	697	K>M		No	ClinGen gnomAD
rs1184610844 CA379997781	699	A>D		No	ClinGen TOPMed
TCGA novel	699	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs769474687 CA5937793	700	V>I		No	ClinGen ExAC TOPMed gnomAD
rs776213981 CA5937791	702	P>A		No	ClinGen ExAC gnomAD
CA5937790 rs768101813	702	P>L		No	ClinGen ExAC gnomAD
rs747539023 CA5937789	703	P>T		No	ClinGen ExAC gnomAD
TCGA novel	704	V>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs772471859 CA5937787	705	H>R		No	ClinGen ExAC gnomAD
CA5937788 rs377162271	705	H>Y		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	711	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1199997337 CA379997653	717	R>Q		No	ClinGen gnomAD

No associated diseases with Q12996

11 regional properties for Q12996

Type	Name	Position	InterPro Accession
repeat	HAT (Half-A-TPR) repeat	45 - 77	IPR003107-1
repeat	HAT (Half-A-TPR) repeat	79 - 110	IPR003107-2
repeat	HAT (Half-A-TPR) repeat	117 - 152	IPR003107-3
repeat	HAT (Half-A-TPR) repeat	163 - 196	IPR003107-4
repeat	HAT (Half-A-TPR) repeat	229 - 261	IPR003107-5
repeat	HAT (Half-A-TPR) repeat	271 - 303	IPR003107-6
repeat	HAT (Half-A-TPR) repeat	319 - 352	IPR003107-7
repeat	HAT (Half-A-TPR) repeat	354 - 387	IPR003107-8
repeat	HAT (Half-A-TPR) repeat	424 - 456	IPR003107-9
repeat	HAT (Half-A-TPR) repeat	458 - 494	IPR003107-10
domain	Suppressor of forked	375 - 649	IPR008847

Functions

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name	Definition
mRNA binding	Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
RNA binding	Binding to an RNA molecule or a portion thereof.

3 GO annotations of biological process

Name	Definition
mRNA cleavage	Any process in which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner.
mRNA polyadenylation	The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript.
RNA 3'-end processing	Any process involved in forming the mature 3' end of an RNA molecule.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P25298	RNA14	mRNA 3'-end-processing protein RNA14	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q99LI7	Cstf3	Cleavage stimulation factor subunit 3	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MSGDGATEQA	AEYVPEKVKK	AEKKLEENPY	DLDAWSILIR	EAQNQPIDKA	RKTYERLVAQ
70	80	90	100	110	120
FPSSGRFWKL	YIEAEIKAKN	YDKVEKLFQR	CLMKVLHIDL	WKCYLSYVRE	TKGKLPSYKE
130	140	150	160	170	180
KMAQAYDFAL	DKIGMEIMSY	QIWVDYINFL	KGVEAVGSYA	ENQRITAVRR	VYQRGCVNPM
190	200	210	220	230	240
INIEQLWRDY	NKYEEGINIH	LAKKMIEDRS	RDYMNARRVA	KEYETVMKGL	DRNAPSVPPQ
250	260	270	280	290	300
NTPQEAQQVD	MWKKYIQWEK	SNPLRTEDQT	LITKRVMFAY	EQCLLVLGHH	PDIWYEAAQY
310	320	330	340	350	360
LEQSSKLLAE	KGDMNNAKLF	SDEAANIYER	AISTLLKKNM	LLYFAYADYE	ESRMKYEKVH
370	380	390	400	410	420
SIYNRLLAIE	DIDPTLVYIQ	YMKFARRAEG	IKSGRMIFKK	AREDTRTRHH	VYVTAALMEY
430	440	450	460	470	480
YCSKDKSVAF	KIFELGLKKY	GDIPEYVLAY	IDYLSHLNED	NNTRVLFERV	LTSGSLPPEK
490	500	510	520	530	540
SGEIWARFLA	FESNIGDLAS	ILKVEKRRFT	AFKEEYEGKE	TALLVDRYKF	MDLYPCSASE
550	560	570	580	590	600
LKALGYKDVS	RAKLAAIIPD	PVVAPSIVPV	LKDEVDRKPE	YPKPDTQQMI	PFQPRHLAPP
610	620	630	640	650	660
GLHPVPGGVF	PVPPAAVVLM	KLLPPPICFQ	GPFVQVDELM	EIFRRCKIPN	TVEEAVRIIT
670	680	690	700	710
GGAPELAVEG	NGPVESNAVL	TKAVKRPNED	SDEDEEKGAV	VPPVHDIYRA	RQQKRIR