Q99KJ8
PR
Gene name |
Dctn2 |
Protein name |
Dynactin subunit 2 |
Names |
50 kDa dynein-associated polypeptide, Dynactin complex 50 kDa subunit, DCTN-50, Growth cone membrane protein 23-48K, GMP23-48K, p50 dynamitin |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:69654 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q99KJ8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q99KJ8-F1 | Predicted | AlphaFoldDB |
21 variants for Q99KJ8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389127973 | 8 | D>Y | No | EVA | |
| rs3389123700 | 12 | I>T | No | EVA | |
| rs3389141719 | 68 | D>N | No | EVA | |
| rs3389123694 | 72 | R>L | No | EVA | |
| rs3389128027 | 75 | K>E | No | EVA | |
| rs3389141763 | 94 | G>E | No | EVA | |
| rs3401552017 | 129 | T>N | No | EVA | |
| rs3389129626 | 137 | V>M | No | EVA | |
| rs3389131027 | 147 | Q>K | No | EVA | |
| rs3389120411 | 184 | T>I | No | EVA | |
| rs217741577 | 199 | A>D | No | EVA | |
| rs256018337 | 199 | A>P | No | EVA | |
| rs217741577 | 199 | A>V | No | EVA | |
| rs3389109110 | 220 | S>F | No | EVA | |
| rs3389071018 | 231 | R>H | No | EVA | |
| rs3389132915 | 247 | N>I | No | EVA | |
| rs3389131059 | 260 | E>K | No | EVA | |
| rs3389131049 | 268 | K>* | No | EVA | |
| rs3389141157 | 347 | F>Y | No | EVA | |
| rs3389104344 | 352 | T>P | No | EVA | |
| rs3389128014 | 371 | L>H | No | EVA |
No associated diseases with Q99KJ8
No regional properties for Q99KJ8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q99KJ8 | |||
10 GO annotations of cellular component
| Name | Definition |
|---|---|
| centrosome | A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| dynactin complex | A 20S multiprotein assembly of total mass about 1.2 MDa that activates dynein-based activity in vivo. A large structural component of the complex is an actin-like 40 nm filament composed of actin-related protein, to which other components attach. |
| dynein complex | Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity. |
| growth cone | The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic. |
| kinetochore | A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| microtubule | Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. |
| vesicle | Any small, fluid-filled, spherical organelle enclosed by membrane. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| identical protein binding | Binding to an identical protein or proteins. |
| protein kinase binding | Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. |
| spectrin binding | Binding to spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| melanosome transport | The directed movement of melanosomes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| mitotic cell cycle | Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. |
| mitotic metaphase plate congression | The cell cycle process in which chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the mitotic spindle, during mitosis. |
| mitotic spindle organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle. |
| protein localization to centrosome | A process in which a protein is transported to, or maintained at, the centrosome. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MADPKYADLP | GIARNEPDVY | ETSDLPEDDQ | AEFDAEELSS | TSVEHIIVNP | NAAYDKFKDK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RVGTKGLDFS | DRIGKTKRTG | YESGDYEMLG | EGLGVKETPQ | QKYQRLLHEV | QELTTEVEKI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KTTVKESATE | EKLTPVVLAK | QLAALKQQLV | ASHLEKLLGP | DAAINLADPD | GALAKRLLLQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LEATKSSKGS | SGGKATAGAP | PDSSLVTYEL | HSRPEQDKFS | QAAKVAELEK | RLTELEATVR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| CDQDAQNPLS | AGLQGACLME | TVELLQAKVS | ALDLAVLDQV | EARLQSVLGK | VNEIAKHKAS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VEDADTQNKV | HQLYETIQRW | SPVASTLPEL | VQRLVTIKQL | HEQAMQFGQL | LTHLDTTQQM |
| 370 | 380 | 390 | 400 | ||
| MASSLKDNTA | LLTQVQTTMR | ENLATVEGNF | ASIDARMKRL | GK |