Q99KI3

PR
Gene name
Emc3 (Tmem111)
Protein name
ER membrane protein complex subunit 3
Names
Transmembrane protein 111
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:66087
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

59-133 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q99KI3

Entry ID Method Resolution Chain Position Source
AF-Q99KI3-F1 Predicted AlphaFoldDB

7 variants for Q99KI3

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3397395960 29 M>R No EVA
rs3388846755 32 H>P No EVA
rs3388854517 54 V>A No EVA
rs3397395944 97 P>Q No EVA
rs3388854548 106 M>T No EVA
rs3388846726 242 M>L No EVA
rs3388835234 242 M>T No EVA

No associated diseases with Q99KI3

No regional properties for Q99KI3

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q99KI3

Functions

Description
EC Number
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
EMC complex A transmembrane protein complex located in the endoplasmic reticulum (ER) involved in the insertion of newly synthesized proteins in the membrane of the ER. In S. cerevisiae, it has six members: EMC1, EMC2, AIM27, EMC4, KRE27, and EMC6.
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of endoplasmic reticulum membrane The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

1 GO annotations of molecular function

Name Definition
membrane insertase activity Binds transmembrane domain-containing proteins and mediates their integration into a membrane.

2 GO annotations of biological process

Name Definition
protein insertion into ER membrane by stop-transfer membrane-anchor sequence A process of protein insertion into the endoplasmic reticulum (ER) membrane in which stop-transfer membrane-anchor sequences become an ER membrane spanning helix.
tail-anchored membrane protein insertion into ER membrane A process of protein insertion into the endoplasmic reticulum (ER) membrane in which a tail-anchored (TA) transmembrane protein is incorporated into an endoplasmic reticulum (ER) membrane. TA transmembrane protein, also named type II transmembrane proteins, contain a single C- terminal transmembrane region.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3ZCB8 EMC3 ER membrane protein complex subunit 3 Bos taurus (Bovine) PR
Q9P0I2 EMC3 ER membrane protein complex subunit 3 Homo sapiens (Human) PR
Q5U2V8 Emc3 ER membrane protein complex subunit 3 Rattus norvegicus (Rat) PR
Q7SXW4 emc3 ER membrane protein complex subunit 3 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MAGPELLLDS NIRLWVVLPI VIITFFVGMI RHYVSILLQS DKKLTQEQVS DSQVLIRSRV
70 80 90 100 110 120
LRENGKYIPK QSFLTRKYYF NNPEDGFFKK TKRKVVPPSP MTDPTMLTDM MKGNVTNVLP
130 140 150 160 170 180
MILIGGWINM TFSGFVTTKV PFPLTLRFKP MLQQGIELLT LDASWVSSAS WYFLNVFGLR
190 200 210 220 230 240
SIYSLILGQD NAADQSRMMQ EQMTGAAMAM PADTNKAFKT EWEALELTDH QWALDDVEEE
250 260
LMARDLHFEG MFKKELQTSI F