Q7SXW4

PR
Gene name
emc3 (pob, tmem111, zgc:63727)
Protein name
ER membrane protein complex subunit 3
Names
Protein pob, Transmembrane protein 111
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:406826
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

58-138 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7SXW4

Entry ID Method Resolution Chain Position Source
AF-Q7SXW4-F1 Predicted AlphaFoldDB

No variants for Q7SXW4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7SXW4

No associated diseases with Q7SXW4

No regional properties for Q7SXW4

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q7SXW4

Functions

Description
EC Number
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
EMC complex A transmembrane protein complex located in the endoplasmic reticulum (ER) involved in the insertion of newly synthesized proteins in the membrane of the ER. In S. cerevisiae, it has six members: EMC1, EMC2, AIM27, EMC4, KRE27, and EMC6.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
integral component of endoplasmic reticulum membrane The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
trans-Golgi network transport vesicle A vesicle that mediates transport between the trans-Golgi network and other parts of the cell.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

4 GO annotations of biological process

Name Definition
photoreceptor cell maintenance Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light.
protein insertion into ER membrane by stop-transfer membrane-anchor sequence A process of protein insertion into the endoplasmic reticulum (ER) membrane in which stop-transfer membrane-anchor sequences become an ER membrane spanning helix.
retina development in camera-type eye The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.
tail-anchored membrane protein insertion into ER membrane A process of protein insertion into the endoplasmic reticulum (ER) membrane in which a tail-anchored (TA) transmembrane protein is incorporated into an endoplasmic reticulum (ER) membrane. TA transmembrane protein, also named type II transmembrane proteins, contain a single C- terminal transmembrane region.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3ZCB8 EMC3 ER membrane protein complex subunit 3 Bos taurus (Bovine) PR
Q9P0I2 EMC3 ER membrane protein complex subunit 3 Homo sapiens (Human) PR
Q99KI3 Emc3 ER membrane protein complex subunit 3 Mus musculus (Mouse) PR
Q5U2V8 Emc3 ER membrane protein complex subunit 3 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MAEPELLLDS NIRLWVVLPI VFITFLVGVI RHYVSILLQS DKKLTLEQVS DSQVLIRSRV
70 80 90 100 110 120
LRENGKYIPK QSFLMRKFYF NNQEDGFFKK TKRKVVPPSP MTDPSMLTDM MKGNVTNVLP
130 140 150 160 170 180
MILIGGWINW TFSGFVTTKV PFPLTLRFKP MLQQGIELLS LDASWVSSAS WYFLNVFGLR
190 200 210 220 230 240
SMYSLILGQD NGADQSRIMQ EQMSGAAMAM PADTNKAFKA EWEALELTDH QWALENVEED
250 260
LMSKDLDLSG MFSKDLPTGI F