Q3ZCB8
Gene name |
EMC3 (TMEM111) |
Protein name |
ER membrane protein complex subunit 3 |
Names |
Transmembrane protein 111 |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:508371 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q3ZCB8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q3ZCB8-F1 | Predicted | AlphaFoldDB |
49 variants for Q3ZCB8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs472058723 | 2 | A>E | No | EVA | |
| rs472058723 | 2 | A>G | No | EVA | |
| rs460970184 | 5 | E>G | No | EVA | |
| rs463698672 | 7 | L>S | No | EVA | |
| rs477361450 | 8 | L>I | No | EVA | |
| rs445199033 | 9 | D>A | No | EVA | |
| rs465367030 | 10 | S>F | No | EVA | |
| rs479064454 | 17 | V>F | No | EVA | |
| rs447836141 | 22 | I>N | No | EVA | |
| rs467952510 | 23 | I>V | No | EVA | |
| rs436624891 | 24 | T>P | No | EVA | |
| rs470475287 | 26 | F>C | No | EVA | |
| rs456692456 | 26 | F>I | No | EVA | |
| rs432682846 | 26 | F>L | No | EVA | |
| rs451953180 | 27 | V>G | No | EVA | |
| rs472042310 | 29 | M>K | No | EVA | |
| rs440862129 | 30 | I>L | No | EVA | |
| rs454502828 | 30 | I>T | No | EVA | |
| rs477291494 | 40 | S>R | No | EVA | |
| rs463540935 | 40 | S>R | No | EVA | |
| rs458929748 | 41 | D>A | No | EVA | |
| rs479035726 | 41 | D>E | No | EVA | |
| rs439496075 | 41 | D>Y | No | EVA | |
| rs447767752 | 42 | K>E | No | EVA | |
| rs467837530 | 42 | K>N | No | EVA | |
| rs481600795 | 43 | K>N | No | EVA | |
| rs450220440 | 44 | L>R | No | EVA | |
| rs432653112 | 45 | T>P | No | EVA | |
| rs452736640 | 47 | E>D | No | EVA | |
| rs465574856 | 50 | S>A | No | EVA | |
| rs434379259 | 51 | D>H | No | EVA | |
| rs136916942 | 65 | G>V | No | EVA | |
| rs442372090 | 86 | G>V | No | EVA | |
| rs456071082 | 94 | K>N | No | EVA | |
| rs438503189 | 100 | P>H | No | EVA | |
| rs458573340 | 101 | V>E | No | EVA | |
| rs474853966 | 126 | G>R | No | EVA | |
| rs481972994 | 157 | E>G | No | EVA | |
| rs450647178 | 159 | L>P | No | EVA | |
| rs522489332 | 165 | W>R | No | EVA | |
| rs441135848 | 192 | A>G | No | EVA | |
| rs460531233 | 193 | A>T | No | EVA | |
| rs449319198 | 200 | Q>R | No | EVA | |
| rs483123898 | 204 | T>S | No | EVA | |
| rs445420056 | 206 | A>T | No | EVA | |
| rs465566302 | 208 | M>I | No | EVA | |
| rs467374931 | 215 | N>K | No | EVA | |
| rs435920929 | 218 | F>L | No | EVA | |
| rs468355662 | 225 | L>V | No | EVA |
No associated diseases with Q3ZCB8
No regional properties for Q3ZCB8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q3ZCB8 | |||
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| EMC complex | A transmembrane protein complex located in the endoplasmic reticulum (ER) involved in the insertion of newly synthesized proteins in the membrane of the ER. In S. cerevisiae, it has six members: EMC1, EMC2, AIM27, EMC4, KRE27, and EMC6. |
| integral component of endoplasmic reticulum membrane | The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| membrane insertase activity | Binds transmembrane domain-containing proteins and mediates their integration into a membrane. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| protein insertion into ER membrane by stop-transfer membrane-anchor sequence | A process of protein insertion into the endoplasmic reticulum (ER) membrane in which stop-transfer membrane-anchor sequences become an ER membrane spanning helix. |
| tail-anchored membrane protein insertion into ER membrane | A process of protein insertion into the endoplasmic reticulum (ER) membrane in which a tail-anchored (TA) transmembrane protein is incorporated into an endoplasmic reticulum (ER) membrane. TA transmembrane protein, also named type II transmembrane proteins, contain a single C- terminal transmembrane region. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9P0I2 | EMC3 | ER membrane protein complex subunit 3 | Homo sapiens (Human) | PR |
| Q99KI3 | Emc3 | ER membrane protein complex subunit 3 | Mus musculus (Mouse) | PR |
| Q5U2V8 | Emc3 | ER membrane protein complex subunit 3 | Rattus norvegicus (Rat) | PR |
| Q7SXW4 | emc3 | ER membrane protein complex subunit 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAGPELLLDS | NIRLWVVLPI | VIITFFVGMI | RHYVSILLQS | DKKLTQEQVS | DSQVLIRSRV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LRENGKYIPK | QSFLTRKYYF | NNPEDGFFKK | TKRKVVPPSP | VTDPTMLTDM | MKGNVTNVLP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| MILIGGWINM | TFSGFVTTKV | PFPLTLRFKP | MLQQGIELLT | LDASWVSSAS | WYFLNVFGLR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SIYSLILGQD | NAADQSRMMQ | EQMTGAAMAM | PADTNKAFKT | EWEALELTDH | QWALDDVEEE |
| 250 | 260 | ||||
| LMAKDLHFEG | MFKKELQTSI | F |