Q99JU7

PR
Gene name
Bnipl
Protein name
Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein
Names
Species
Mus musculus (Mouse)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-63 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q99JU7

Entry ID Method Resolution Chain Position Source
AF-Q99JU7-F1 Predicted AlphaFoldDB

11 variants for Q99JU7

Variant ID(s) Position Change Description Diseaes Association Provenance
rs1133860734 153 R>Q No EVA
rs3393358983 198 S>R No EVA
rs3388642582 208 H>N No EVA
rs3388643035 239 V>M No EVA
rs3388647462 264 V>M No EVA
rs3388646423 266 V>I No EVA
rs3388644612 292 R>S No EVA
rs3393394117 295 D>A No EVA
rs3393394129 298 G>R No EVA
rs3413125047 301 A>S No EVA
rs223783742 302 Q>K No EVA

No associated diseases with Q99JU7

3 regional properties for Q99JU7

Type Name Position InterPro Accession
domain Protein kinase domain 77 - 327 IPR000719
active_site Serine/threonine-protein kinase, active site 196 - 208 IPR008271
binding_site Protein kinase, ATP binding site 83 - 106 IPR017441

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name Definition
identical protein binding Binding to an identical protein or proteins.

3 GO annotations of biological process

Name Definition
apoptotic process A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
negative regulation of cell population proliferation Any process that stops, prevents or reduces the rate or extent of cell proliferation.
regulation of growth rate Any process that modulates the rate of growth of all or part of an organism.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O54940 Bnip2 BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 Mus musculus (Mouse) PR
Q8BHE3 Atcay Caytaxin Mus musculus (Mouse) PR
10 20 30 40 50 60
MKLGELELRE EWQDEEFPRL LPEEPGSPGD PEDPQRGSQA GTPSSLALCG QRPMRKRLSA
70 80 90 100 110 120
PEWQLSLTEG TGENGASPTR SASSSSAGSL DLEVDELETP SDSEQLDSGH EFEWEDDLPR
130 140 150 160 170 180
AEGLGASEAA ERLGRGCVCD VAGEDGHRWR VFRTGQREQR VDMTIIEPYK KVLSHGGYHG
190 200 210 220 230 240
DGLNAVILFA SCYLPRSSIP NYTYIMEHLF RYMVGTLELL VAENYLLVHL SGGTSRAQVP
250 260 270 280 290 300
PLSWIRQCYR TLDRRLRKNL RALVVVHATW YVKAFLALVR PFISSKFTRK IRFLDSLGEL
310 320
AQLISLEQVH IPEVVRQLDR DLHGSKGT