Q99JR6
Gene name |
Nmnat3 |
Protein name |
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 |
Names |
NMN/NaMN adenylyltransferase 3, Nicotinamide-nucleotide adenylyltransferase 3, NMN adenylyltransferase 3, Nicotinate-nucleotide adenylyltransferase 3, NaMN adenylyltransferase 3 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:74080 |
EC number |
2.7.7.1: Nucleotidyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q99JR6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 5Z9R | X-ray | 200 A | A/B | 1-245 | PDB |
| AF-Q99JR6-F1 | Predicted | AlphaFoldDB |
17 variants for Q99JR6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3400014954 | 30 | R>T | No | EVA | |
| rs3400681245 | 31 | D>G | No | EVA | |
| rs3389068656 | 120 | P>L | No | EVA | |
| rs221562018 | 125 | A>V | No | EVA | |
| rs3389068679 | 150 | T>A | No | EVA | |
| rs3389045345 | 155 | I>K | No | EVA | |
| rs3400593085 | 156 | V>L | No | EVA | |
| rs3400792102 | 158 | K>N | No | EVA | |
| rs258611913 | 161 | L>V | No | EVA | |
| rs3400544883 | 167 | S>G | No | EVA | |
| rs226029296 | 204 | V>I | No | EVA | |
| rs3400551079 | 209 | G>* | No | EVA | |
| rs3400593072 | 230 | G>A | No | EVA | |
| rs3400345953 | 232 | Y>* | No | EVA | |
| rs3400792118 | 240 | G>V | No | EVA | |
| rs3400221668 | 240 | G>W | No | EVA | |
| rs248474343 | 243 | K>N | No | EVA |
No associated diseases with Q99JR6
1 regional properties for Q99JR6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cytidyltransferase-like domain | 10 - 207 | IPR004821 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.7.1 | Nucleotidyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| axon | The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| neuronal cell body | The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| nicotinamide-nucleotide adenylyltransferase activity | Catalysis of the reaction: ATP + nicotinamide nucleotide = diphosphate + NAD+. |
| nicotinate-nucleotide adenylyltransferase activity | Catalysis of the reaction: ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| NAD biosynthetic process | The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH. |
| response to tumor necrosis factor | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus. |
| response to wounding | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9BZQ4 | NMNAT2 | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 | Homo sapiens (Human) | PR |
| P91851 | nmat-2 | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 | Caenorhabditis elegans | PR |
| Q6PC93 | nmnat2 | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKNRIPVVLL | ACGSFNPITN | MHLRLFEVAR | DHLHQTGRYQ | VIEGIISPVN | DSYGKKDLVA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SHHRVAMARL | ALQTSDWIRV | DPWESEQAQW | METVKVLRHH | HRELLRSSAQ | MDGPDPSKTP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SASAALPELK | LLCGADVLKT | FQTPNLWKDT | HIQEIVEKFG | LVCVSRSGHD | PERYISDSPI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LQQFQHNIHL | AREPVLNEIS | ATYVRKALGQ | GQSVKYLLPE | AVITYIRDQG | LYINDGSWKG |
| KGKTG |