P91851
Gene name |
nmat-2 |
Protein name |
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 |
Names |
NMN/NaMN adenylyltransferase 2, Nicotinamide mononucleotide adenylyltransferase 2, NMN adenylyltransferase 2, Nicotinate-nucleotide adenylyltransferase 2, NaMN adenylyltransferase 2 |
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_F26H9.4 |
EC number |
2.7.7.1: Nucleotidyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P91851
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P91851-F1 | Predicted | AlphaFoldDB |
No variants for P91851
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P91851 | |||||
No associated diseases with P91851
1 regional properties for P91851
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cytidyltransferase-like domain | 7 - 195 | IPR004821 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.7.1 | Nucleotidyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| nicotinamide-nucleotide adenylyltransferase activity | Catalysis of the reaction: ATP + nicotinamide nucleotide = diphosphate + NAD+. |
| nicotinate-nucleotide adenylyltransferase activity | Catalysis of the reaction: ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| NAD biosynthetic process | The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9BZQ4 | NMNAT2 | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 | Homo sapiens (Human) | PR |
| Q99JR6 | Nmnat3 | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | Mus musculus (Mouse) | PR |
| Q6PC93 | nmnat2 | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKRVALLAVG | SFNPPTIAHL | RMLEVARSHL | ETINTQVVEG | IMSPVADSYN | NKPTLIKSNF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RIQMVRAATK | SSDWIRADDW | ECTRTTWTRT | IDVLRHHREL | VQEKFGSDVG | MMLVVGGDVV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DSFTRILPDG | SNLWNSSDIR | TIITEFGLIV | LSREGSNPLN | TIQSMPAISE | FCDRIIQVKD |
| 190 | 200 | 210 | 220 | ||
| EVCPSGVSST | RLRAAIMNKK | SIKYSTPDEV | INFIRENNLY | QKI |