Q6PC93
Gene name |
nmnat2 (si:dkey-161l11.3) |
Protein name |
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 |
Names |
NMN/NaMN adenylyltransferase 2, Nicotinamide mononucleotide adenylyltransferase 2, NMN adenylyltransferase 2, Nicotinate-nucleotide adenylyltransferase 2, NaMN adenylyltransferase 2 |
Species |
Danio rerio (Zebrafish) (Brachydanio rerio) |
KEGG Pathway |
dre:336257 |
EC number |
2.7.7.1: Nucleotidyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6PC93
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6PC93-F1 | Predicted | AlphaFoldDB |
No variants for Q6PC93
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6PC93 | |||||
No associated diseases with Q6PC93
1 regional properties for Q6PC93
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cytidyltransferase-like domain | 14 - 271 | IPR004821 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.7.1 | Nucleotidyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| axon | The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. |
| cytoplasmic vesicle membrane | The lipid bilayer surrounding a cytoplasmic vesicle. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| nicotinamide-nucleotide adenylyltransferase activity | Catalysis of the reaction: ATP + nicotinamide nucleotide = diphosphate + NAD+. |
| nicotinate-nucleotide adenylyltransferase activity | Catalysis of the reaction: ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+. |
| protein ADP-ribosyltransferase-substrate adaptor activity | An enzyme-substrate adaptor that bings together a protein ADP-ribosyl transferase and its substrate. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| NAD biosynthetic process | The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9BZQ4 | NMNAT2 | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 | Homo sapiens (Human) | PR |
| Q99JR6 | Nmnat3 | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | Mus musculus (Mouse) | PR |
| P91851 | nmat-2 | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTENTKTHVI | LLSCGSFNPI | TKGHIHMFEK | AREYLHKTGR | FIVIGGIVSP | VHDSYGKPGL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VPSRHRLTMC | QLAVQSSDWI | RVDPWECYQD | TWQTTCSVLE | HHRDLMKRVT | GCILSNVNTP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| STTPVIGQPQ | NETSAIYQNT | VNKSVAIKFW | GKMSESLGKI | CCVRPHMDRF | TFVDENANLG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TAMRYEEIEL | RILLLCGSDL | LESFCIPGLW | NESDMEVIVG | DFGIVVVPRD | GADTERIMNH |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SSVLRKHKDN | IIVVKDEIDH | PMSIVSSTKS | RLALQHGDGH | VVDYLSQPVI | DYILQSQLYI |
| NASG |