AiPD: Autoinhibited Protein Database

Q99442

Gene name	SEC62 (TLOC1)
Protein name	Translocation protein SEC62
Names	Translocation protein 1, TP-1, hTP-1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:7095
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

77-198 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

77-198 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for Q99442

Entry ID	Method	Resolution	Chain	Position	Source
7BRT	X-ray	200 A	A/B	361-376	PDB
AF-Q99442-F1	Predicted				AlphaFoldDB

233 variants for Q99442

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA355090267 rs1339101671	2	A>G		No	ClinGen TOPMed gnomAD
rs1339101671 CA355090269	2	A>V		No	ClinGen TOPMed gnomAD
rs1412787003 CA355090299	5	R>G		No	ClinGen gnomAD
rs1336138309 CA355090303	5	R>K		No	ClinGen gnomAD
CA2699057 rs762236006	7	H>N		No	ClinGen ExAC gnomAD
rs1228831361 CA355090335	7	H>Q		No	ClinGen TOPMed gnomAD
CA355090328 rs762236006	7	H>Y		No	ClinGen ExAC gnomAD
rs770118827 CA2699059	9	K>N		No	ClinGen ExAC TOPMed gnomAD
CA355090361 rs1343459504	9	K>R		No	ClinGen gnomAD
CA355090375 rs1423735649	10	R>L		No	ClinGen TOPMed
rs1261966351 CA355090371	10	R>W		No	ClinGen gnomAD
rs138379777 CA2699060	11	I>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA355090380 rs1461540335	11	I>V		No	ClinGen TOPMed gnomAD
CA355090394 rs1576852751	12	Q>*		No	ClinGen Ensembl
rs1260510087 CA355090400	12	Q>R		No	ClinGen TOPMed
CA355074048 rs1559964547	24	V>M		No	ClinGen Ensembl
CA2699081 rs774349665	28	L>F		No	ClinGen ExAC gnomAD
rs1406881255 CA355074168	29	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1245020010 CA355074186	30	F>L		No	ClinGen gnomAD
rs759646862 CA2699083	31	N>D		No	ClinGen ExAC gnomAD
CA2699082 rs759646862	31	N>H		No	ClinGen ExAC gnomAD
CA2699084 rs78992980	31	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2699085 rs761682982	32	C>S		No	ClinGen ExAC gnomAD
rs186147407 CA87602198	34	T>A		No	ClinGen 1000Genomes gnomAD
rs186147407 CA355074308	34	T>S		No	ClinGen 1000Genomes gnomAD
rs867322447 CA87602201	37	T>A		No	ClinGen Ensembl
CA2699086 rs765071900	37	T>I		No	ClinGen ExAC TOPMed gnomAD
CA355074386 rs1179196846	38	N>H		No	ClinGen gnomAD
rs750254201 CA2699087	39	M>V		No	ClinGen ExAC gnomAD
TCGA novel	41	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs758054837 CA2699088	43	R>G		No	ClinGen ExAC gnomAD
rs1184669999 CA355074555	43	R>Q		No	ClinGen gnomAD
rs1270083046 CA355075818	53	V>M		No	ClinGen gnomAD
rs1424860200 CA355076020	58	D>G		No	ClinGen TOPMed
CA2699110 rs767004839	58	D>Y		No	ClinGen ExAC gnomAD
rs1191653497 CA355076081	60	K>N		No	ClinGen TOPMed
rs752162637 CA2699111	60	K>R		No	ClinGen ExAC gnomAD
CA355076122 rs1477927087	62	A>S		No	ClinGen gnomAD
rs756548326 CA2699112	66	K>Q		No	ClinGen ExAC gnomAD
rs1445464288 CA355076258 COSM1287808	67	G>R	Variant assessed as Somatic; 0.0 impact. autonomic_ganglia [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1215600677 CA355076507	78	V>A		No	ClinGen gnomAD
CA2699113 rs778250141	81	Y>H		No	ClinGen ExAC gnomAD
rs765461271 CA87604653	85	L>F		No	ClinGen Ensembl
rs758444719 CA87604662	89	Q>H		No	ClinGen Ensembl
rs752886088 CA87604657	89	Q>K		No	ClinGen Ensembl
rs1285444016 COSM4153017 CA355077660	90	F>L	kidney [Cosmic]	No	ClinGen cosmic curated gnomAD
TCGA novel	92	H>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs180699945 CA2699138	93	R>*		No	ClinGen 1000Genomes ExAC gnomAD
CA355077687 rs1325620228	93	R>Q		No	ClinGen gnomAD
CA2699139 rs143177437	94	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA2699142 rs781454297	97	V>I		No	ClinGen ExAC TOPMed gnomAD
CA355077708 rs781454297	97	V>L		No	ClinGen ExAC TOPMed gnomAD
CA355077727 rs1360866978	99	K>R		No	ClinGen gnomAD
rs774131957 CA2699145	101	K>N		No	ClinGen ExAC gnomAD
rs770791327 CA2699144	101	K>R		No	ClinGen ExAC gnomAD
rs1180435962 CA355077754	103	D>H		No	ClinGen gnomAD
CA2699146 rs759249292	105	D>Y		No	ClinGen ExAC gnomAD
rs771963028 CA2699147	108	K>E		No	ClinGen ExAC gnomAD
CA355077856 rs1576860898	109	E>D		No	ClinGen Ensembl
CA2699148 rs202090306	109	E>K		No	ClinGen ExAC gnomAD
CA355077898 CA355077900 rs142871056	111	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs372456767 CA355077890	111	D>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs372456767 CA2699149	111	D>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA2699153 rs753355540	115	A>D		No	ClinGen ExAC TOPMed gnomAD
rs1366121023 CA355077978	115	A>T		No	ClinGen TOPMed
CA355078038 rs1409508619	117	S>N		No	ClinGen TOPMed gnomAD
CA2699155 rs572291779	118	G>R		No	ClinGen 1000Genomes ExAC gnomAD
CA2699157 rs750994854	119	K>E		No	ClinGen ExAC
rs1314812960 CA355078136	120	E>A		No	ClinGen gnomAD
rs867639779 CA87604841	120	E>K		No	ClinGen gnomAD
rs1314812960 CA355078141	120	E>V		No	ClinGen gnomAD
rs866257367 CA87604843	121	E>K		No	ClinGen Ensembl
CA355078200 rs1268980861	122	D>E		No	ClinGen gnomAD
TCGA novel	122	D>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs866931174 CA87604844	122	D>N		No	ClinGen gnomAD
CA355078186 rs866931174	122	D>Y		No	ClinGen gnomAD
CA355078246 rs1219836827	124	K>N		No	ClinGen TOPMed gnomAD
rs758670384 CA2699159	124	K>R		No	ClinGen ExAC gnomAD
CA355078300 rs1258128779	125	S>R		No	ClinGen TOPMed gnomAD
rs1194799698 CA355078291	125	S>T		No	ClinGen gnomAD
CA355078329 rs1201310223 COSM1041021	126	K>N	endometrium [Cosmic]	No	ClinGen cosmic curated gnomAD
rs200340300 CA2699160	126	K>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs766058747 CA2699161	127	K>T		No	ClinGen ExAC
rs751792463 CA2699162	128	E>*		No	ClinGen ExAC gnomAD
rs751792463 CA355078374	128	E>K		No	ClinGen ExAC gnomAD
CA355078434 rs1189336104	129	N>I		No	ClinGen gnomAD
rs897727271 CA87604880	129	N>Y		No	ClinGen gnomAD
rs1271713146 CA355078478	130	I>T		No	ClinGen TOPMed
CA2699164 rs201421974	130	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA355078574 rs1168630236	132	D>E		No	ClinGen gnomAD
TCGA novel	133	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA355078629 rs1468436130	135	T>A		No	ClinGen gnomAD
rs1336277507 CA355078648	135	T>I		No	ClinGen TOPMed gnomAD
rs1336277507 CA355078635	135	T>K		No	ClinGen TOPMed gnomAD
CA355078695 rs1398196327	138	E>K		No	ClinGen gnomAD
CA355078767 rs1316675410	140	E>K		No	ClinGen gnomAD
TCGA novel	142	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs751191303	144	D>M	Variant assessed as Somatic; 5.529e-05 impact. [NCI-TCGA]	No	NCI-TCGA
CA355078917 rs1437324205	144	D>Y		No	ClinGen gnomAD
TCGA novel	153	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs777938101 CA2699188	154	E>G		No	ClinGen ExAC gnomAD
rs1036600710 CA87605134	155	T>I		No	ClinGen TOPMed gnomAD
CA355079390 rs1559966324	155	T>P		No	ClinGen Ensembl
CA355079406 rs1349632594	156	P>A		No	ClinGen gnomAD
rs1364914167 CA355079421	157	G>A		No	ClinGen TOPMed
rs745741130 CA2699189	159	P>H		No	ClinGen ExAC gnomAD
CA355079442 rs1184541026	159	P>S		No	ClinGen TOPMed
rs758366354 CA2699190	164	T>A		No	ClinGen ExAC TOPMed gnomAD
rs779753003 CA2699191	166	K>R		No	ClinGen ExAC gnomAD
CA2699192 rs746802900	170	L>F		No	ClinGen ExAC gnomAD
CA355079665 rs1435131949	172	P>T		No	ClinGen gnomAD
CA2699193 rs150642223	177	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA2699194 rs368648934	180	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA355079798 rs1160789880	181	G>R		No	ClinGen gnomAD
rs760738195 CA2699221	186	V>I		No	ClinGen ExAC gnomAD
rs1241718311 CA355080749	189	Y>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs754066230 CA2699223	194	F>C		No	ClinGen ExAC gnomAD
rs1182785818 CA355080885	196	T>A		No	ClinGen TOPMed gnomAD
rs1416644255 CA355080903	197	F>L		No	ClinGen gnomAD
TCGA novel	201	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs761859410 CA355081033	203	L>F		No	ClinGen ExAC TOPMed gnomAD
CA2699224 rs761859410	203	L>I		No	ClinGen ExAC TOPMed gnomAD
CA355081082 rs1252787715	205	I>V		No	ClinGen TOPMed
CA355081089 rs1401973005	206	A>T		No	ClinGen gnomAD
CA355081103 rs1347204556	208	I>T		No	ClinGen TOPMed
CA355081101 rs1398039986	208	I>V		No	ClinGen TOPMed gnomAD
CA355081111 rs1367183145	209	A>V		No	ClinGen gnomAD
CA2699245 rs759402629	211	T>I		No	ClinGen ExAC gnomAD
CA355081122 rs759402629	211	T>N		No	ClinGen ExAC gnomAD
CA355081167 rs1287413431	218	A>S		No	ClinGen TOPMed gnomAD
rs1242667346 CA355081180	220	M>V		No	ClinGen gnomAD
rs1576863932 CA355081200	222	V>G		No	ClinGen Ensembl
CA355081207 rs1559967484	224	V>I		No	ClinGen Ensembl
rs755919368 CA2699248	225	Y>D		No	ClinGen ExAC gnomAD
rs1576863944 CA355081223	226	Y>S		No	ClinGen Ensembl
rs1427036197 CA355081251	230	G>D		No	ClinGen gnomAD
rs753504229 CA2699250	233	C>F		No	ClinGen ExAC
CA355081272 rs1157798739	233	C>W		No	ClinGen gnomAD
CA2699251 rs756980184	234	F>S		No	ClinGen ExAC TOPMed gnomAD
rs200028953 CA2699252	235	V>L		No	ClinGen 1000Genomes ExAC gnomAD
CA2699254 rs758036420	236	A>V		No	ClinGen ExAC TOPMed gnomAD
rs780586958 CA2699255	237	S>G		No	ClinGen ExAC gnomAD
rs1276877406 CA355081301	238	I>T		No	ClinGen gnomAD
rs747510631 CA2699256	239	L>I		No	ClinGen ExAC gnomAD
rs1310430988 CA355081323	242	A>S		No	ClinGen gnomAD
CA2699257 rs769022898	243	V>I		No	ClinGen ExAC TOPMed gnomAD
CA87607978 rs1036740894	244	A>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA355082185 rs1228467346	245	R>Q		No	ClinGen gnomAD
rs1200327109 CA355082192	246	C>R		No	ClinGen TOPMed
rs747499714 CA2699273	247	I>V		No	ClinGen ExAC gnomAD
rs755455194 CA2699274	248	L>P		No	ClinGen ExAC gnomAD
CA355082315 rs1458961019	251	I>M		No	ClinGen gnomAD
CA2699275 rs781470019	253	W>C		No	ClinGen ExAC gnomAD
TCGA novel	255	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1473077496 CA355082452	260	H>R		No	ClinGen TOPMed gnomAD
rs1480292182 CA355082564	267	N>S		No	ClinGen TOPMed
CA355082596 rs1417384859	270	A>T		No	ClinGen gnomAD
rs1402700487 CA355082669	274	F>L		No	ClinGen gnomAD
CA87609913 rs1057428695	275	I>T		No	ClinGen TOPMed
rs1282256469 CA355082782	281	L>V		No	ClinGen TOPMed
rs911576357 CA87609944	283	T>S		No	ClinGen Ensembl
rs771004739 CA2699280	284	H>R		No	ClinGen ExAC gnomAD
rs1450743038 CA355082829	285	E>K		No	ClinGen gnomAD
CA355082876 rs1217456328	288	G>E		No	ClinGen gnomAD
rs1315471381 CA355082873	288	G>R		No	ClinGen gnomAD
CA355082897 rs1319550141	290	K>E		No	ClinGen TOPMed gnomAD
rs1198576439 CA355082932	292	D>E		No	ClinGen TOPMed gnomAD
CA355082972 rs768471417 CA2699283	294	K>N		No	ClinGen ExAC TOPMed gnomAD
rs776763843 CA2699284	296	D>A		No	ClinGen ExAC TOPMed gnomAD
rs776763843 CA87609961	296	D>V		No	ClinGen ExAC TOPMed gnomAD
CA2699285 rs761675139	298	K>N		No	ClinGen ExAC gnomAD
rs946545429 CA87609962	302	K>R		No	ClinGen Ensembl
CA355083140 rs1426134545	306	K>T		No	ClinGen gnomAD
rs762533262 CA2699289	308	D>N		No	ClinGen ExAC TOPMed gnomAD
CA2699290 rs765856488	309	S>G		No	ClinGen ExAC TOPMed gnomAD
rs765856488 CA355083171	309	S>R		No	ClinGen ExAC TOPMed gnomAD
rs751037370 CA2699291	311	E>K		No	ClinGen ExAC gnomAD
rs1316899031 CA355083206	312	K>E		No	ClinGen gnomAD
CA87610004 rs999461917	313	S>T		No	ClinGen Ensembl
CA87610008 rs1056843778	315	S>C		No	ClinGen gnomAD
rs1056843778 CA355083240	315	S>G		No	ClinGen gnomAD
rs1398919036 CA355083244	315	S>N		No	ClinGen gnomAD
CA355083249 COSM582656 rs1177450218	315	S>R	lung [Cosmic]	No	ClinGen cosmic curated TOPMed
rs754584323 CA2699292	319	E>G		No	ClinGen ExAC gnomAD
CA2699295 CA2699296 rs34352823	321	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2699294 rs781656299	321	E>G		No	ClinGen ExAC TOPMed gnomAD
CA355083344 rs1283847389	323	G>R		No	ClinGen gnomAD
CA355083374 rs1399561174	325	V>A		No	ClinGen gnomAD
CA2699298 rs749481489	327	P>L		No	ClinGen ExAC gnomAD
CA355083469 rs1157224042	334	G>S		No	ClinGen gnomAD
CA2699301 rs779259601	335	S>L		No	ClinGen ExAC TOPMed gnomAD
CA2699300 rs779259601	335	S>W		No	ClinGen ExAC TOPMed gnomAD
rs769662010 CA2699306	336	G>A		No	ClinGen ExAC gnomAD
CA2699305 rs769662010	336	G>E		No	ClinGen ExAC gnomAD
CA87610050 CA355083489 rs377711845	336	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA2699304 rs377711845	336	G>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA2699308 rs765944822	339	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs762601555 CA2699307	339	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA355083589 rs1352920986	345	S>N		No	ClinGen gnomAD
rs1352920986 CA355083591	345	S>T		No	ClinGen gnomAD
rs201905627 CA2699311	347	R>G		No	ClinGen ExAC TOPMed gnomAD
rs753166992 CA2699312	349	E>G		No	ClinGen ExAC gnomAD
CA355083682 rs141360935	352	R>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2699313 rs141360935	352	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs146483233 COSM1041026 CA2699314	352	R>Q	endometrium [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs1268396120 CA355083725	355	H>Q		No	ClinGen gnomAD
rs1018282934 CA87610098	357	S>N		No	ClinGen TOPMed
CA355083854 rs1248036268	366	I>V		No	ClinGen Ensembl
CA355083866 rs1158142648	367	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA2699317 rs778976281	368	K>E		No	ClinGen ExAC gnomAD
CA2699318 rs746138382	376	D>Y		No	ClinGen ExAC gnomAD
rs1455969248 CA355083994	377	G>E		No	ClinGen gnomAD
CA2699321 rs748038777	379	C>Y		No	ClinGen ExAC gnomAD
TCGA novel	381	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1388095402 CA355084047	381	E>D		No	ClinGen gnomAD
CA2699322 rs769857452	382	D>G		No	ClinGen ExAC gnomAD
CA87610117 rs995653710	384	E>K		No	ClinGen Ensembl
rs1025849299 CA87610129	385	E>D		No	ClinGen Ensembl
CA2699324 rs749025420	385	E>V		No	ClinGen ExAC gnomAD
rs770810328 CA2699325	387	N>D		No	ClinGen ExAC gnomAD
rs773848101 CA2699326	387	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1244224978 CA355084113	388	D>G		No	ClinGen gnomAD
rs1027638351 CA87610145	390	E>K		No	ClinGen TOPMed
CA2699328 rs766969275	391	T>I		No	ClinGen ExAC gnomAD
CA87610148 rs951689927	392	P>S		No	ClinGen TOPMed
rs141059280 CA2699330	393	K>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1281707029 CA355084151	394	S>F		No	ClinGen TOPMed
CA2699333 rs143053763	396	H>L		No	ClinGen ESP ExAC gnomAD
rs180829030 CA2699334	396	H>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2699332 rs143053763	396	H>R		No	ClinGen ESP ExAC gnomAD
CA2699331 rs764568264	396	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA355084163 rs1163480637	397	E>K		No	ClinGen gnomAD
rs758933075 CA2699335	397	E>V		No	ClinGen ExAC TOPMed gnomAD

No associated diseases with Q99442

No regional properties for Q99442

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q99442

Functions

		Description
EC Number
Subcellular Localization	Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
integral component of endoplasmic reticulum membrane	The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
rough endoplasmic reticulum	The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae.

1 GO annotations of molecular function

Name	Definition
signaling receptor activity	Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.

3 GO annotations of biological process

Name	Definition
cotranslational protein targeting to membrane	The targeting of proteins to a membrane that occurs during translation. The transport of most secretory proteins, particularly those with more than 100 amino acids, into the endoplasmic reticulum lumen occurs in this manner, as does the import of some proteins into mitochondria.
post-translational protein targeting to endoplasmic reticulum membrane	The targeting of proteins to a membrane that occurs after their translation. Some secretory proteins exhibit posttranslational transport into the endoplasmic reticulum (ER) lumen: they are synthesized in their entirety on free cytosolic ribosomes and then released into the cytosol, where they are bound by chaperones which keep them in an unfolded state, and subsequently are translocated across the ER membrane.
post-translational protein targeting to membrane, translocation	The process in which a protein translocates through the ER membrane posttranslationally.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q5F3A1	SEC62	Translocation protein SEC62	Gallus gallus (Chicken)	PR
Q8BU14	Sec62	Translocation protein SEC62	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MAERRRHKKR	IQEVGEPSKE	EKAVAKYLRF	NCPTKSTNMM	GHRVDYFIAS	KAVDCLLDSK
70	80	90	100	110	120
WAKAKKGEEA	LFTTRESVVD	YCNRLLKKQF	FHRALKVMKM	KYDKDIKKEK	DKGKAESGKE
130	140	150	160	170	180
EDKKSKKENI	KDEKTKKEKE	KKKDGEKEES	KKEETPGTPK	KKETKKKFKL	EPHDDQVFLD
190	200	210	220	230	240
GNEVYVWIYD	PVHFKTFVMG	LILVIAVIAA	TLFPLWPAEM	RVGVYYLSVG	AGCFVASILL
250	260	270	280	290	300
LAVARCILFL	IIWLITGGRH	HFWFLPNLTA	DVGFIDSFRP	LYTHEYKGPK	ADLKKDEKSE
310	320	330	340	350	360
TKKQQKSDSE	EKSDSEKKED	EEGKVGPGNH	GTEGSGGERH	SDTDSDRRED	DRSQHSSGNG
370	380	390
NDFEMITKEE	LEQQTDGDCE	EDEEEENDGE	TPKSSHEKS