Q8BU14
Gene name |
Sec62 (Tloc1) |
Protein name |
Translocation protein SEC62 |
Names |
Translocation protein 1, TP-1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:69276 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8BU14
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8BU14-F1 | Predicted | AlphaFoldDB |
9 variants for Q8BU14
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388623502 | 29 | R>L | No | EVA | |
| rs3392656999 | 178 | F>* | No | EVA | |
| rs3388613964 | 192 | V>D | No | EVA | |
| rs3388622510 | 293 | L>V | No | EVA | |
| rs3388618034 | 355 | H>N | No | EVA | |
| rs3388627989 | 371 | L>M | No | EVA | |
| rs3388613920 | 377 | G>R | No | EVA | |
| rs3388620481 | 379 | C>S | No | EVA | |
| rs216575625 | 390 | V>M | No | EVA |
No associated diseases with Q8BU14
No regional properties for Q8BU14
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q8BU14 | |||
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| integral component of endoplasmic reticulum membrane | The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| post-translational protein targeting to endoplasmic reticulum membrane | The targeting of proteins to a membrane that occurs after their translation. Some secretory proteins exhibit posttranslational transport into the endoplasmic reticulum (ER) lumen: they are synthesized in their entirety on free cytosolic ribosomes and then released into the cytosol, where they are bound by chaperones which keep them in an unfolded state, and subsequently are translocated across the ER membrane. |
| post-translational protein targeting to membrane, translocation | The process in which a protein translocates through the ER membrane posttranslationally. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAERRRHKKR | IQEVGEPSKE | EKAVAKYLRF | NCPTKSTNMM | GHRVDYFIAS | KAVECLLDSK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| WAKAKKGEDA | LFTTRESVVD | YCNRLLKKQF | FHRALKVMKM | KYDKDVKKEK | DKGKSESGKE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DDKKSKKESV | KEEKTKKEKE | KKKDGEKEDS | KKEETPGTPK | KKETKKKFKL | EPHDDQVFLD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GNEVFVWIYD | PVHIKTFVMG | LILVIAVIAA | TLFPLWPAEM | RVGVYYLSVG | AGCFVASILL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LAIARCILFL | IIWLITGGRH | HFWFLPNLTA | DVGFIDSFRP | LYTHEYKGPK | ADLKKDEKSE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TKKQQKSDSE | EKSDSEKKED | EEGKGAPADH | GPEGSGGERH | SDTDSDRRED | DRSQHSSGNG |
| 370 | 380 | 390 | |||
| NDFEMITKEE | LEQQTDGDCD | EEDDDKDGEV | PKSAHEKS |