Q98949

PR
Gene name
TYRO3 (REK)
Protein name
Tyrosine-protein kinase receptor TYRO3
Names
Retina-expressed kinase, Rek
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:395336
EC number
2.7.10.1: Protein-tyrosine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

425-501 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

659-684 (Activation loop from InterPro)

Target domain

505-776 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q98949

Entry ID Method Resolution Chain Position Source
AF-Q98949-F1 Predicted AlphaFoldDB

No variants for Q98949

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q98949

No associated diseases with Q98949

13 regional properties for Q98949

Type Name Position InterPro Accession
domain Protein kinase domain 505 - 776 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 506 - 773 IPR001245
domain Immunoglobulin subtype 2 43 - 112 IPR003598
domain Immunoglobulin subtype 37 - 124 IPR003599-1
domain Immunoglobulin subtype 133 - 210 IPR003599-2
domain Fibronectin type III 213 - 308 IPR003961-1
domain Fibronectin type III 310 - 403 IPR003961-2
domain Immunoglobulin-like domain 10 - 122 IPR007110-1
domain Immunoglobulin-like domain 127 - 208 IPR007110-2
active_site Tyrosine-protein kinase, active site 638 - 650 IPR008266
domain Immunoglobulin I-set 32 - 116 IPR013098
binding_site Protein kinase, ATP binding site 511 - 537 IPR017441
domain Tyrosine-protein kinase, catalytic domain 505 - 773 IPR020635

Functions

Description
EC Number 2.7.10.1 Protein-tyrosine kinases
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
receptor complex Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
transmembrane receptor protein tyrosine kinase activity Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.

6 GO annotations of biological process

Name Definition
cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
cell migration The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
nervous system development The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
phagocytosis A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
positive regulation of kinase activity Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
transmembrane receptor protein tyrosine kinase signaling pathway The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.

15 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q91044 NTRK3 NT-3 growth factor receptor Gallus gallus (Chicken) SS
Q8AXY6 MUSK Muscle, skeletal receptor tyrosine protein kinase Gallus gallus (Chicken) SS
Q5F3X2 DDR1 receptor protein-tyrosine kinase Gallus gallus (Chicken) SS
Q91987 NTRK2 BDNF/NT-3 growth factors receptor Gallus gallus (Chicken) SS
Q8QHL3 FLT1 Vascular endothelial growth factor receptor 1 Gallus gallus (Chicken) SS
P21804 FGFR1 Fibroblast growth factor receptor 1 Gallus gallus (Chicken) SS
P18461 FGFR2 Fibroblast growth factor receptor 2 Gallus gallus (Chicken) SS
P18460 FGFR3 Fibroblast growth factor receptor 3 Gallus gallus (Chicken) SS
Q08156 KIT Mast/stem cell growth factor receptor Kit Gallus gallus (Chicken) SS
Q07494 EPHB1 Ephrin type-B receptor 1 Gallus gallus (Chicken) SS
Q91009 NTRK1 High affinity nerve growth factor receptor Gallus gallus (Chicken) SS
Q9PUF6 PDGFRA Platelet-derived growth factor receptor alpha Gallus gallus (Chicken) SS
Q06418 TYRO3 Tyrosine-protein kinase receptor TYRO3 Homo sapiens (Human) SS
P55144 Tyro3 Tyrosine-protein kinase receptor TYRO3 Mus musculus (Mouse) SS
Q9YI66 tyro3 Tyrosine-protein kinase receptor TYRO3 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MELRRSMALP RLLLLGLWAA ALRDGAVAAG MKFTGSPIKL KVSQGQPVKL NCSLEGMEDP
70 80 90 100 110 120
EMLWIKDGAV VQSVDQVYIP VDEDHWIGFL SLKSVERTDS GKYWCQVENG GKKEESQQVW
130 140 150 160 170 180
LIVEGVPYFT VEPEDVSVSP NAPFHMACAA VGPPEPVTIV WWMGDSRVGL PDISPSILNV
190 200 210 220 230 240
SGINQSTMFS CEAHNVKGLS SSRTATVQIK AMPLPPLNVT VSQVTSSNAS VVWVPGFDGR
250 260 270 280 290 300
APLHSCTLQV AESPDGQEVS TEVAPVPPFA YGVQGLKHST NYSVRVQCSN EMGSSPFTER
310 320 330 340 350 360
VYFQTLELAP SSTPQNIHVI QRDPGLVLEW EGVAPDVLKE NVLGYRLEWI QDNVTQGEMI
370 380 390 400 410 420
VQDTKANLTT WNPLKDLIIR VCVLNSAGCG PWSDLFLLEA QEVMGGQRQP PYGTSWVPVA
430 440 450 460 470 480
LGILTALVTA VALALILLRK RRKETRFGHA FGSVVGRGDP AVHFRAARSF NREGPELIEA
490 500 510 520 530 540
TLESVGISDE LKTKLKDVLI QEQQFTLGRM LGKGEFGSVR EALLKLDDGS FQKVAVKMLK
550 560 570 580 590 600
ADIFTSTDIE EFLREAACMK EFDHPHVTKL IGVSLRSRPK GRLPIPMVIL PFMKHGDLHA
610 620 630 640 650 660
FLLMSRIGEN PFNLPLQTLL KFMIDIASGM EYLSSKNFIH RDLAARNCML DENMNVSVAD
670 680 690 700 710 720
FGLSKKIYSG DYYRQGCASK LPVKWLALES LADNLYTTHS DVWAFGVTMW EIVTRGQTPY
730 740 750 760 770 780
AGIENAEIYN YLISGNRLKQ PPECLEDVYD LMCRCWHPEP KLRPSFGVLR SQLEMIRGRM
790 800 810 820 830 840
STLSLSQDPL YVNIGKDKES SVSDPAVHTS FGNTDGDETI AGAAAAAITS DYRYIMSPLC
850 860 870
LGDDVEGERH PEGQEGENKS LLYELETEGE KSC