Q8QHL3
SS
Gene name |
FLT1 (VEGFR1) |
Protein name |
Vascular endothelial growth factor receptor 1 |
Names |
VEGFR-1 , EC 2.7.10.1 |
Species |
Gallus gallus (Chicken) |
KEGG Pathway |
gga:374100 |
EC number |
2.7.10.1: Protein-tyrosine kinases |
Protein Class |
|
Descriptions
The vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) play crucial roles in vasculogenesis and angiogenesis. The unphosphorylated juxtamembrane region of VEGFR2 autoinhibits kinase activity by interacting with the activation loop in the kinase domain. Like other receptor tyrosine kinases, VEGFRs may have other autoinhibitory regions.
Autoinhibitory domains (AIDs)
Target domain |
819-1149 (Protein kinase domain) |
Relief mechanism |
PTM |
Assay |
|
Accessory elements
No accessory elements
References
- Roskoski R Jr (2008) "VEGF receptor protein-tyrosine kinases: structure and regulation", Biochemical and biophysical research communications, 375, 287-91
- Wang X et al. (2020) "Molecular Bases of VEGFR-2-Mediated Physiological Function and Pathological Role", Frontiers in cell and developmental biology, 8, 599281
- Shewchuk LM et al. (2000) "Structure of the Tie2 RTK domain: self-inhibition by the nucleotide binding loop, activation loop, and C-terminal tail", Structure (London, England : 1993), 8, 1105-13
- Stuttfeld E et al. (2009) "Structure and function of VEGF receptors", IUBMB life, 61, 915-22
Autoinhibited structure
Activated structure
1 structures for Q8QHL3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8QHL3-F1 | Predicted | AlphaFoldDB |
No variants for Q8QHL3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q8QHL3 | |||||
No associated diseases with Q8QHL3
28 regional properties for Q8QHL3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 819 - 1151 | IPR000719 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 819 - 1147 | IPR001245 |
| conserved_site | Tyrosine-protein kinase, receptor class III, conserved site | 878 - 891 | IPR001824 |
| domain | Immunoglobulin subtype 2 | 42 - 112 | IPR003598-1 |
| domain | Immunoglobulin subtype 2 | 239 - 314 | IPR003598-2 |
| domain | Immunoglobulin subtype 2 | 441 - 538 | IPR003598-3 |
| domain | Immunoglobulin subtype 2 | 564 - 633 | IPR003598-4 |
| domain | Immunoglobulin subtype 2 | 663 - 728 | IPR003598-5 |
| domain | Immunoglobulin subtype | 36 - 123 | IPR003599-1 |
| domain | Immunoglobulin subtype | 139 - 220 | IPR003599-2 |
| domain | Immunoglobulin subtype | 233 - 325 | IPR003599-3 |
| domain | Immunoglobulin subtype | 340 - 421 | IPR003599-4 |
| domain | Immunoglobulin subtype | 435 - 549 | IPR003599-5 |
| domain | Immunoglobulin subtype | 558 - 648 | IPR003599-6 |
| domain | Immunoglobulin subtype | 657 - 739 | IPR003599-7 |
| domain | Immunoglobulin-like domain | 30 - 106 | IPR007110-1 |
| domain | Immunoglobulin-like domain | 240 - 323 | IPR007110-2 |
| domain | Immunoglobulin-like domain | 359 - 417 | IPR007110-3 |
| domain | Immunoglobulin-like domain | 424 - 545 | IPR007110-4 |
| domain | Immunoglobulin-like domain | 552 - 644 | IPR007110-5 |
| domain | Immunoglobulin-like domain | 651 - 737 | IPR007110-6 |
| active_site | Tyrosine-protein kinase, active site | 1011 - 1023 | IPR008266 |
| domain | Immunoglobulin I-set | 347 - 403 | IPR013098-1 |
| domain | Immunoglobulin I-set | 652 - 738 | IPR013098-2 |
| domain | Immunoglobulin-like beta-sandwich domain | 236 - 316 | IPR013151 |
| binding_site | Protein kinase, ATP binding site | 825 - 853 | IPR017441 |
| domain | Tyrosine-protein kinase, catalytic domain | 819 - 1147 | IPR020635 |
| domain | VEGFR-2, transmembrane domain | 743 - 776 | IPR041348 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.10.1 | Protein-tyrosine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| endosome | A vacuole to which materials ingested by endocytosis are delivered. |
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| receptor complex | Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| growth factor binding | Binding to a growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate. |
| vascular endothelial growth factor receptor activity | Combining with a vascular endothelial growth factor (VEGF) receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| angiogenesis | Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. |
| cell differentiation | The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| chemotaxis | The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). |
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
| vascular endothelial growth factor receptor signaling pathway | The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor (VEGFR) on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
76 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P43481 | KIT | Mast/stem cell growth factor receptor Kit | Bos taurus (Bovine) | SS |
| Q06805 | TIE1 | Tyrosine-protein kinase receptor Tie-1 | Bos taurus (Bovine) | PR |
| Q06807 | TEK | Angiopoietin-1 receptor | Bos taurus (Bovine) | SS |
| Q28889 | KIT | Mast/stem cell growth factor receptor Kit | Felis catus (Cat) (Felis silvestris catus) | SS |
| P13369 | CSF1R | Macrophage colony-stimulating factor 1 receptor | Felis catus (Cat) (Felis silvestris catus) | SS |
| Q8AXY6 | MUSK | Muscle, skeletal receptor tyrosine protein kinase | Gallus gallus (Chicken) | SS |
| Q5F3X2 | DDR1 | receptor protein-tyrosine kinase | Gallus gallus (Chicken) | SS |
| Q91987 | NTRK2 | BDNF/NT-3 growth factors receptor | Gallus gallus (Chicken) | SS |
| Q91044 | NTRK3 | NT-3 growth factor receptor | Gallus gallus (Chicken) | SS |
| P21804 | FGFR1 | Fibroblast growth factor receptor 1 | Gallus gallus (Chicken) | SS |
| P18461 | FGFR2 | Fibroblast growth factor receptor 2 | Gallus gallus (Chicken) | SS |
| P18460 | FGFR3 | Fibroblast growth factor receptor 3 | Gallus gallus (Chicken) | SS |
| Q98949 | TYRO3 | Tyrosine-protein kinase receptor TYRO3 | Gallus gallus (Chicken) | PR |
| Q08156 | KIT | Mast/stem cell growth factor receptor Kit | Gallus gallus (Chicken) | SS |
| Q9PUF6 | PDGFRA | Platelet-derived growth factor receptor alpha | Gallus gallus (Chicken) | SS |
| Q91009 | NTRK1 | High affinity nerve growth factor receptor | Gallus gallus (Chicken) | SS |
| Q07494 | EPHB1 | Ephrin type-B receptor 1 | Gallus gallus (Chicken) | SS |
| Q07407 | htl | Fibroblast growth factor receptor homolog 1 | Drosophila melanogaster (Fruit fly) | PR |
| Q6J9G0 | STYK1 | Tyrosine-protein kinase STYK1 | Homo sapiens (Human) | PR |
| P36888 | FLT3 | Receptor-type tyrosine-protein kinase FLT3 | Homo sapiens (Human) | EV |
| P16234 | PDGFRA | Platelet-derived growth factor receptor alpha | Homo sapiens (Human) | EV |
| P09619 | PDGFRB | Platelet-derived growth factor receptor beta | Homo sapiens (Human) | EV |
| P35916 | FLT4 | Vascular endothelial growth factor receptor 3 | Homo sapiens (Human) | SS |
| P35968 | KDR | Vascular endothelial growth factor receptor 2 | Homo sapiens (Human) | EV |
| P07333 | CSF1R | Macrophage colony-stimulating factor 1 receptor | Homo sapiens (Human) | SS |
| P10721 | KIT | Mast/stem cell growth factor receptor Kit | Homo sapiens (Human) | EV |
| P22455 | FGFR4 | Fibroblast growth factor receptor 4 | Homo sapiens (Human) | SS |
| P22607 | FGFR3 | Fibroblast growth factor receptor 3 | Homo sapiens (Human) | EV |
| P07949 | RET | Proto-oncogene tyrosine-protein kinase receptor Ret | Homo sapiens (Human) | EV |
| P35590 | TIE1 | Tyrosine-protein kinase receptor Tie-1 | Homo sapiens (Human) | PR |
| Q02763 | TEK | Angiopoietin-1 receptor | Homo sapiens (Human) | SS |
| P11362 | FGFR1 | Fibroblast growth factor receptor 1 | Homo sapiens (Human) | EV |
| P21802 | FGFR2 | Fibroblast growth factor receptor 2 | Homo sapiens (Human) | EV |
| P17948 | FLT1 | Vascular endothelial growth factor receptor 1 | Homo sapiens (Human) | SS |
| Q03142 | Fgfr4 | Fibroblast growth factor receptor 4 | Mus musculus (Mouse) | PR |
| P05532 | Kit | Mast/stem cell growth factor receptor Kit | Mus musculus (Mouse) | PR |
| Q91V87 | Fgfrl1 | Fibroblast growth factor receptor-like 1 | Mus musculus (Mouse) | PR |
| P35917 | Flt4 | Vascular endothelial growth factor receptor 3 | Mus musculus (Mouse) | SS |
| P05622 | Pdgfrb | Platelet-derived growth factor receptor beta | Mus musculus (Mouse) | SS |
| P09581 | Csf1r | Macrophage colony-stimulating factor 1 receptor | Mus musculus (Mouse) | SS |
| P35546 | Ret | Proto-oncogene tyrosine-protein kinase receptor Ret | Mus musculus (Mouse) | SS |
| Q06806 | Tie1 | Tyrosine-protein kinase receptor Tie-1 | Mus musculus (Mouse) | SS |
| Q00342 | Flt3 | Receptor-type tyrosine-protein kinase FLT3 | Mus musculus (Mouse) | SS |
| Q6J9G1 | Styk1 | Tyrosine-protein kinase STYK1 | Mus musculus (Mouse) | PR |
| P16092 | Fgfr1 | Fibroblast growth factor receptor 1 | Mus musculus (Mouse) | SS |
| Q61851 | Fgfr3 | Fibroblast growth factor receptor 3 | Mus musculus (Mouse) | PR |
| Q02858 | Tek | Angiopoietin-1 receptor | Mus musculus (Mouse) | SS |
| P35918 | Kdr | Vascular endothelial growth factor receptor 2 | Mus musculus (Mouse) | PR |
| P21803 | Fgfr2 | Fibroblast growth factor receptor 2 | Mus musculus (Mouse) | SS |
| P26618 | Pdgfra | Platelet-derived growth factor receptor alpha | Mus musculus (Mouse) | SS |
| P35969 | Flt1 | Vascular endothelial growth factor receptor 1 | Mus musculus (Mouse) | SS |
| Q2HWD6 | KIT | Mast/stem cell growth factor receptor Kit | Sus scrofa (Pig) | SS |
| Q7TQM3 | Fgfrl1 | Fibroblast growth factor receptor-like 1 | Rattus norvegicus (Rat) | PR |
| P20786 | Pdgfra | Platelet-derived growth factor receptor alpha | Rattus norvegicus (Rat) | SS |
| Q91ZT1 | Flt4 | Vascular endothelial growth factor receptor 3 | Rattus norvegicus (Rat) | SS |
| Q04589 | Fgfr1 | Fibroblast growth factor receptor 1 | Rattus norvegicus (Rat) | SS |
| G3V9H8 | Ret | Proto-oncogene tyrosine-protein kinase receptor Ret | Rattus norvegicus (Rat) | SS |
| Q498D6 | Fgfr4 | Fibroblast growth factor receptor 4 | Rattus norvegicus (Rat) | PR |
| Q05030 | Pdgfrb | Platelet-derived growth factor receptor beta | Rattus norvegicus (Rat) | SS |
| O08775 | Kdr | Vascular endothelial growth factor receptor 2 | Rattus norvegicus (Rat) | SS |
| P53767 | Flt1 | Vascular endothelial growth factor receptor 1 | Rattus norvegicus (Rat) | PR |
| Q17833 | old-1 | Tyrosine-protein kinase receptor old-1 | Caenorhabditis elegans | PR |
| Q19238 | F09A5.2 | Putative tyrosine-protein kinase F09A5.2 | Caenorhabditis elegans | SS |
| Q10656 | egl-15 | Myoblast growth factor receptor egl-15 | Caenorhabditis elegans | PR |
| P34892 | kin-16 | Receptor-like tyrosine-protein kinase kin-16 | Caenorhabditis elegans | PR |
| G5ED65 | ver-1 | Protein ver-1 | Caenorhabditis elegans | PR |
| Q8AXB3 | kdrl | Vascular endothelial growth factor receptor kdr-like | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q5GIT4 | kdr | Vascular endothelial growth factor receptor 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O73791 | tek | Angiopoietin-1 receptor | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q90Z00 | fgfr1a | Fibroblast growth factor receptor 1-A | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q8JG38 | fgfr2 | Fibroblast growth factor receptor 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q9I8N6 | csf1r | Macrophage colony-stimulating factor 1 receptor | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q90413 | fgfr4 | Fibroblast growth factor receptor 4 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q9DE49 | pdgfra | Platelet-derived growth factor receptor alpha | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q8JFR5 | kita | Mast/stem cell growth factor receptor kita | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q5MD89 | flt4 | Vascular endothelial growth factor receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPRQLLSGTV | LLGAAFLLAG | STSGSKLKVP | VLSVNGRQHV | VQAGQTLNLT | CRGEMLHSWS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LPEALSKDSK | RLNVTKYACG | RNGTQFCSTL | TLSRTQANDT | GRYSCRYPTS | PVKKKRESIV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YVFINDTSNP | FVEMHSDIPK | IIHMTVGKEM | IIPCRVTAPN | IAVTLKKIPR | ETLIPDGKTI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IWDNMRGFRI | PEATYRFIGL | LSCETTIGGH | KYSTKYLTHR | ETNTIFDIKL | STPRLVKLLK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GDSLAINCTV | KAAWNTRVQM | TWTYPGEAMK | RGSVTQRIDQ | KNREANVFYS | ILVIDKVRDI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DKGQYACHVK | SGPSNKLVNT | TVIVYDKRFI | NLKRRRKTML | EAVAGRKSYR | LPMKVKAFPS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PEVTWLKDGL | PAAEKCARYM | VKNYSLIIKD | VAEEDAGNYT | IILSLRQWNL | SKNLTVTLKV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NVKPQIYENA | VSSFPDPNLY | LLSSKQVLTC | TVYGIPPPKI | TWMWYPCRQN | HSKTRRGFCS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| RTDGSFNLKT | GSNIGNRIQS | IIERTAIIEG | KNKTASTLVV | AEAKSSGIYS | CVASNKVGKA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ERNVSFLVTD | VPSGFHISLE | KVPIEGENLV | LSCSANKFMY | KDISWILPRT | VTNQTKARKA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LNKEYSITLT | LTIRNVSLAH | SGTYTCRARN | IFTGKEVLQK | KDVSIRAQEA | PALLRQLMDQ |
| 670 | 680 | 690 | 700 | 710 | 720 |
| TVNTSNSAML | ECQVHGIPEP | QITWFKNHEE | IQQESGIILG | PGSRMLFIER | VKEEDEGLYQ |
| 730 | 740 | 750 | 760 | 770 | 780 |
| CIATNLKGSV | ESTAYVTVQG | TVERSNLELI | TLTCTCVAAT | LFWLLLTLFI | RKLKRPYFSE |
| 790 | 800 | 810 | 820 | 830 | 840 |
| TKTNHYLSII | MDPDEVPLDE | QCECLPYDAS | KWEIARERLK | LGKSLGHGAF | GKVVQASAFG |
| 850 | 860 | 870 | 880 | 890 | 900 |
| IKKSPTCRIV | AVKMLKEGAT | ASEYKALMTE | LKILIHIGHH | LNIVNLLGAC | TKNGGPLMVI |
| 910 | 920 | 930 | 940 | 950 | 960 |
| VEYCKYGNLS | NYLKSKRNFF | SPTKDPSLQG | ELMKDKKGIE | PVEGKKQRLA | SVTSSESFAS |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| SGFQEDKSLS | DAEEDEEDAA | ELYKLPLTME | DLISYSFQVA | RGMEFLSSRK | CIHRDLAARN |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| ILLSENNVVK | ICDFGLARDI | YKNPDYVRKG | DARLPLKWMA | PESIFDKIYN | TKSDVWSYGV |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| LLWEIFSLGA | SPYPGVQIDE | DFCSKLKEGT | RMRAPEQATE | EIYQIMLDCW | RSNPNERPWF |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| SELVKRLGDL | LQASVQQEGK | DYIPLDTIFT | AESGFPPASD | PLCNEKFPVP | SPNCRSTERA |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| RYINTFKIKP | PQRIKTFEEL | PIKEKLVFND | YQADSGMVLA | SEELKRFTWT | GSKQKWTLFG |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| MKGVSRSKES | GLSGITKPRS | FCSFSCDQLS | ESKRRYTYGN | TVLEKMKACH | SPPPDYSSVV |
| HYSQPSI |