AiPD: Autoinhibited Protein Database

Q96SN7

Gene name	ORAI2 (C7orf19, CBCIP2, TMEM142B, PP1729)
Protein name	Protein orai-2
Names	CAP-binding protein complex-interacting protein 2, Transmembrane protein 142B
Species	Homo sapiens (Human)
KEGG Pathway	hsa:80228
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-98 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-98 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q96SN7

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q96SN7-F1	Predicted				AlphaFoldDB

181 variants for Q96SN7

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA368693354 rs1217516417	2	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs762289307 CA4412934	2	S>R		No	ClinGen ExAC TOPMed gnomAD
CA368693410 rs1325646203	3	A>T		No	ClinGen gnomAD
rs765364777 CA4412935	5	L>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA4412937 rs375636106	7	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs1586709059 CA368693584	10	D>A		No	ClinGen Ensembl
CA368693581 rs751764863	10	D>H		No	ClinGen ExAC gnomAD
CA4412939 rs751764863	10	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs754858060 CA4412941	11	P>H		No	ClinGen ExAC TOPMed gnomAD
CA368693647 rs1431521667	12	S>T		No	ClinGen gnomAD
rs767396764 CA4412942	13	A>T		No	ClinGen ExAC gnomAD
rs998270514 CA163419675 COSM1635024	13	A>V	liver [Cosmic]	No	ClinGen cosmic curated TOPMed
rs34947403 VAR_053543 CA4412943	15	A>P		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1400623556 CA368693774	16	C>Y		No	ClinGen gnomAD
rs149749759 CA163419686	17	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA4412944 rs149749759	17	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
COSM1547506 CA368693843 rs1340787777	19	P>R	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs201916492 CA4412947	20	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA368693882 rs1233265268	21	H>Y		No	ClinGen gnomAD
CA4412950 rs769061106	22	K>E		No	ClinGen ExAC TOPMed gnomAD
CA4412951 rs145092754	23	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs748442406 CA4412952	24	M>I		No	ClinGen ExAC gnomAD
rs1032474938 CA163419743	24	M>T		No	ClinGen TOPMed
rs764959778 CA163419738	24	M>V		No	ClinGen TOPMed gnomAD
rs1271239276 CA368694023	27	R>Q		No	ClinGen gnomAD
CA368694020 rs1191770260	27	R>W		No	ClinGen gnomAD
CA368694088 rs1586709171	30	V>A		No	ClinGen Ensembl
COSM224944 CA4412953 rs376890782	31	R>C	Variant assessed as Somatic; 0.0 impact. skin [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA368694121 rs1198195830	32	R>C		No	ClinGen gnomAD
rs773716007 CA4412954	32	R>H		No	ClinGen ExAC gnomAD
CA368694306 rs1489389741	39	T>A		No	ClinGen TOPMed
CA368694302 rs1489389741	39	T>P		No	ClinGen TOPMed
COSM72031 CA4412955 rs762973215	40	S>F	ovary Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
TCGA novel	40	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA368694348 rs1586709201	41	N>T		No	ClinGen Ensembl
rs766451025 CA4412956	42	H>Y		No	ClinGen ExAC gnomAD
CA4412958 rs759817341	44	S>L		No	ClinGen ExAC TOPMed gnomAD
CA4412959 rs767488712	46	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs752472055 CA163419787	48	L>V		No	ClinGen TOPMed
rs1299952346 CA368694561 COSM1218895	49	S>L	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1241078361 CA368694606	51	R>Q		No	ClinGen gnomAD
rs1563634517 CA368694602	51	R>W		No	ClinGen Ensembl
CA368694633 rs1352718094	52	K>R		No	ClinGen gnomAD
rs778467745 CA368694761	57	R>S		No	ClinGen ExAC TOPMed gnomAD
rs1295268010 CA368694799	59	K>Q		No	ClinGen TOPMed
CA368694835 rs1209363834	61	K>Q		No	ClinGen gnomAD
rs1586709301 CA368694982	66	T>P		No	ClinGen Ensembl
rs779621605 CA4412968	68	A>T		No	ClinGen ExAC gnomAD
rs1165818339 CA368695196	74	A>P		No	ClinGen gnomAD
CA4412971 rs778181215	75	M>R		No	ClinGen ExAC gnomAD
CA163425156 CA163425155 rs767828985	78	M>I		No	ClinGen TOPMed
CA4412992 rs745969579	85	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA368698723 rs1257480734	85	T>S		No	ClinGen gnomAD
rs1238487367 CA368698737	86	Q>*		No	ClinGen gnomAD
rs1364229442 CA368698749	87	Y>H		No	ClinGen TOPMed
CA368698755 rs1586716712	87	Y>S		No	ClinGen Ensembl
CA4412995 rs760931275	88	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs775898267 CA4412994	88	Q>P		No	ClinGen ExAC gnomAD
rs1586716724 CA368698782	89	Y>S		No	ClinGen Ensembl
CA4412998 rs372227034 COSM421655	91	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA4412997 rs776485301	91	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs765238790 CA4412999	92	P>L		No	ClinGen ExAC gnomAD
rs1422271642 CA368698814	92	P>S		No	ClinGen gnomAD
CA368698829 rs1359615568	93	L>M		No	ClinGen gnomAD
CA368698849 rs1465384567	94	L>P		No	ClinGen gnomAD
CA368698901 rs1300831890	98	S>G		No	ClinGen gnomAD
TCGA novel	98	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs142110959 CA4413002	99	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1277716736 CA368698935	100	C>G		No	ClinGen gnomAD
rs1225362740 CA368698967	102	T>M		No	ClinGen gnomAD
CA368698980 rs1586716809	103	V>G		No	ClinGen Ensembl
CA4413006 rs574075338	107	V>M		No	ClinGen 1000Genomes ExAC gnomAD
CA368699064 rs779595593	111	A>S		No	ClinGen ExAC gnomAD
CA4413009 rs779595593	111	A>T		No	ClinGen ExAC gnomAD
CA163425270 rs946046249	112	L>V		No	ClinGen TOPMed gnomAD
rs780272783 CA4413012	114	I>V		No	ClinGen ExAC gnomAD
CA368699120 rs1173764567	115	S>N		No	ClinGen gnomAD
CA368699130 rs1586716888	116	T>P		No	ClinGen Ensembl
CA368699165 rs1420010074	118	I>T		No	ClinGen gnomAD
CA368699188 rs1267337471	120	P>S		No	ClinGen TOPMed
rs768932841 CA4413014	121	N>I		No	ClinGen ExAC gnomAD
rs1358801241 CA368699223	123	E>K		No	ClinGen gnomAD
CA368699259 rs1586716922	125	V>G		No	ClinGen Ensembl
CA4413015 rs776663542	125	V>M		No	ClinGen ExAC TOPMed gnomAD
CA4413016 rs563177670	132	N>K		No	ClinGen 1000Genomes ExAC gnomAD
rs1367582385 CA368699359	132	N>S		No	ClinGen gnomAD
CA368699356 rs1367582385	132	N>T		No	ClinGen gnomAD
CA4413019 rs762863120	134	I>T		No	ClinGen ExAC gnomAD
rs773182234 CA4413018	134	I>V		No	ClinGen ExAC TOPMed gnomAD
CA4413020 rs765940069	136	E>K		No	ClinGen ExAC gnomAD
TCGA novel	137	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4413021 rs773916186	138	P>L		No	ClinGen ExAC TOPMed gnomAD
rs199552953 CA368699444	139	H>P		No	ClinGen 1000Genomes gnomAD
CA368699447 rs1488155106	139	H>Q		No	ClinGen gnomAD
CA163425317 rs199552953	139	H>R		No	ClinGen 1000Genomes gnomAD
CA4413023 rs373008522	140	E>V		No	ClinGen ESP ExAC gnomAD
COSM1446877 CA4413024 rs752254400	141	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA368699486 rs1289497073	142	M>I		No	ClinGen TOPMed gnomAD
CA4413026 rs765678218	142	M>R		No	ClinGen ExAC gnomAD
rs757681744 CA4413025	142	M>V		No	ClinGen ExAC gnomAD
CA368699499 rs1331590762	143	H>L		No	ClinGen TOPMed
rs1331590762 CA368699498	143	H>P		No	ClinGen TOPMed
TCGA novel	144	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1407275676 CA368699537	145	Y>C		No	ClinGen gnomAD
rs938359890 CA163425338	146	I>V		No	ClinGen Ensembl
CA4413028 rs758973216	147	E>D		No	ClinGen ExAC TOPMed gnomAD
CA368699568 rs1349369932	147	E>K		No	ClinGen TOPMed gnomAD
rs1333969147 CA368699661	152	F>S		No	ClinGen gnomAD
CA4413031 rs369139105	155	V>M		No	ClinGen ESP ExAC gnomAD
CA368699767 rs1229671222	159	L>P		No	ClinGen gnomAD
rs1450549028 CA368699794	161	F>S		No	ClinGen gnomAD
rs1458135670 CA368699828	164	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1164055139 CA368699890	172	K>N		No	ClinGen gnomAD
rs1183795726 CA368699902	174	L>F		No	ClinGen TOPMed gnomAD
CA4413036 rs749014730	174	L>R		No	ClinGen ExAC gnomAD
CA4413037 rs770868690	175	P>L		No	ClinGen ExAC gnomAD
rs185291449 CA4413038	176	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA368699925 rs1446678618	178	A>D		No	ClinGen gnomAD
CA4413039 rs201783515	178	A>T		No	ClinGen 1000Genomes ExAC
CA4413041 rs766552086	179	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA4413040 rs146137368	179	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs760393100 CA4413042	180	R>C		No	ClinGen ExAC TOPMed gnomAD
rs373392032 CA4413043 COSM1218894	180	R>H	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA368699948 rs1162288359	182	P>L		No	ClinGen TOPMed gnomAD
CA163425462 rs1031595730	184	P>L		No	ClinGen Ensembl
CA368699955 rs1318593721	184	P>T		No	ClinGen gnomAD
CA163425469 rs766937231	185	P>L		No	ClinGen ExAC TOPMed gnomAD
CA368699964 rs766937231	185	P>Q		No	ClinGen ExAC TOPMed gnomAD
CA4413046 rs766937231	185	P>R		No	ClinGen ExAC TOPMed gnomAD
rs755131372 CA368699966	186	P>S		No	ClinGen ExAC gnomAD
CA4413048 rs755131372	186	P>T		No	ClinGen ExAC gnomAD
CA4413049 rs781117706	188	P>S		No	ClinGen ExAC gnomAD
CA368699988 rs1471916681	190	S>G		No	ClinGen gnomAD
TCGA novel	191	H>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs777914063 CA4413052	192	T>A		No	ClinGen ExAC gnomAD
rs751979726 CA4413053	192	T>M		No	ClinGen ExAC TOPMed gnomAD
CA368700016 rs1364942912	194	W>*		No	ClinGen TOPMed
CA163425534 rs539030215	195	Q>L		No	ClinGen gnomAD
rs965051431 CA163425541	196	A>T		No	ClinGen TOPMed gnomAD
CA4413055 rs778950283	197	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1188954926 CA368700040	198	L>V		No	ClinGen TOPMed
rs771672896 CA4413057	199	V>L		No	ClinGen ExAC gnomAD
rs1412527471 CA368700060	201	T>I		No	ClinGen gnomAD
rs1563639191 CA368700069	203	I>V		No	ClinGen Ensembl
CA163425570 CA163425584 rs973528230	204	M>I		No	ClinGen TOPMed
CA4413059 rs760199107	205	V>A		No	ClinGen ExAC gnomAD
CA163425589 rs981766695	205	V>L		No	ClinGen TOPMed gnomAD
rs149386719 CA4413062	207	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA368700110 rs1484850225	210	I>V		No	ClinGen gnomAD
CA4413065 rs759954382	212	V>M		No	ClinGen ExAC TOPMed gnomAD
CA4413066 rs768000803	214	F>S		No	ClinGen ExAC
CA4413068 rs756139303	215	T>P		No	ClinGen ExAC gnomAD
rs754030552 CA4413070	216	I>T		No	ClinGen ExAC gnomAD
CA163425650 rs946015117	218	F>L		No	ClinGen TOPMed
CA4413072 rs778562970	220	R>C		No	ClinGen ExAC gnomAD
rs745888656 CA4413073	220	R>H		No	ClinGen ExAC TOPMed gnomAD
CA4413074 rs771911609	224	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA163425698 rs779988736	224	R>H		No	ClinGen ExAC TOPMed gnomAD
rs779988736 CA4413075	224	R>L		No	ClinGen ExAC TOPMed gnomAD
CA368700221 COSM1446880 rs1563639327	227	T>M	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated Ensembl NCI-TCGA
rs1040370027 CA163425734	229	R>C		No	ClinGen TOPMed
CA163425739 rs1055285588	229	R>H		No	ClinGen TOPMed gnomAD
rs1488067898 CA368700236	230	H>Y		No	ClinGen gnomAD
rs776469929 CA4413078	231	N>K		No	ClinGen ExAC TOPMed gnomAD
CA4413080 rs771392636	232	R>C		No	ClinGen ExAC gnomAD
rs894171726 CA163425764	232	R>H		No	ClinGen gnomAD
rs1393747824 CA368700253	233	E>K		No	ClinGen TOPMed gnomAD
CA4413083 rs367893276	235	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA368700277 rs1380574411	236	E>*		No	ClinGen gnomAD
rs1418696781 CA368700280	236	E>V		No	ClinGen gnomAD
rs1286677677 CA368700319	242	V>I		No	ClinGen gnomAD
rs760784577 CA4413085	245	D>E		No	ClinGen ExAC gnomAD
CA368700340 rs1315172714	245	D>Y		No	ClinGen gnomAD
CA4413086 rs764137329	246	G>E		No	ClinGen ExAC gnomAD
CA368700346 CA368700345 rs1448769482	246	G>R		No	ClinGen gnomAD
rs1563639428 CA368700360	248	E>Q		No	ClinGen Ensembl
CA368700378 rs1237151622	249	R>C		No	ClinGen gnomAD
CA4413087 rs754118697	249	R>H		No	ClinGen ExAC TOPMed gnomAD
CA368700385 rs754118697	249	R>L		No	ClinGen ExAC TOPMed gnomAD
rs757418933 CA4413088	252	Q>*		No	ClinGen ExAC gnomAD
TCGA novel	252	Q>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA

No associated diseases with Q96SN7

No regional properties for Q96SN7

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q96SN7

Functions

		Description
EC Number
Subcellular Localization	Cell membrane ; Multi-pass membrane protein	Colocalizes with STIM1 upon store depletion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
growth cone	The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

1 GO annotations of molecular function

Name	Definition
store-operated calcium channel activity	A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores.

1 GO annotations of biological process

Name	Definition
store-operated calcium entry	A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum.

3 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q96D31	ORAI1	Calcium release-activated calcium channel protein 1	Homo sapiens (Human)	PR
Q8BWG9	Orai1	Calcium release-activated calcium channel protein 1	Mus musculus (Mouse)	PR
Q8BH10	Orai2	Protein orai-2	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MSAELNVPID	PSAPACPEPG	HKGMDYRDWV	RRSYLELVTS	NHHSVQALSW	RKLYLSRAKL
70	80	90	100	110	120
KASSRTSALL	SGFAMVAMVE	VQLETQYQYP	RPLLIAFSAC	TTVLVAVHLF	ALLISTCILP
130	140	150	160	170	180
NVEAVSNIHN	LNSISESPHE	RMHPYIELAW	GFSTVLGILL	FLAEVVLLCW	IKFLPVDARR
190	200	210	220	230	240
QPGPPPGPGS	HTGWQAALVS	TIIMVPVGLI	FVVFTIHFYR	SLVRHKTERH	NREIEELHKL
250
KVQLDGHERS	LQVL