Q8BWG9
PR
Gene name |
Orai1 (Cracm1, Tmem142a) |
Protein name |
Calcium release-activated calcium channel protein 1 |
Names |
Protein orai-1, Transmembrane protein 142A |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:109305 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8BWG9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8BWG9-F1 | Predicted | AlphaFoldDB |
21 variants for Q8BWG9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3395765582 | 36 | D>G | No | EVA | |
| rs3388790311 | 133 | V>M | No | EVA | |
| rs3388790343 | 143 | S>C | No | EVA | |
| rs3388776156 | 151 | E>A | No | EVA | |
| rs3388771831 | 158 | N>T | No | EVA | |
| rs3388790334 | 163 | K>Q | No | EVA | |
| rs3388782363 | 176 | L>M | No | EVA | |
| rs3388788679 | 183 | V>L | No | EVA | |
| rs3388796827 | 212 | S>C | No | EVA | |
| rs36753145 | 218 | A>T | No | EVA | |
| rs218058290 | 231 | G>S | No | EVA | |
| rs221428304 | 243 | T>P | No | EVA | |
| rs3388776226 | 247 | V>I | No | EVA | |
| rs3388761284 | 254 | I>F | No | EVA | |
| rs3388787533 | 261 | Y>* | No | EVA | |
| rs3388790556 | 266 | S>R | No | EVA | |
| rs3388786033 | 277 | N>I | No | EVA | |
| rs3388786034 | 277 | N>Y | No | EVA | |
| rs3388791487 | 284 | R>L | No | EVA | |
| rs3388795093 | 297 | L>I | No | EVA | |
| rs3388787529 | 302 | H>Q | No | EVA |
No associated diseases with Q8BWG9
No regional properties for Q8BWG9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q8BWG9 | |||
Functions
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| basolateral plasma membrane | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
| growth cone | The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| membrane raft | Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| plasma membrane raft | A membrane raft that is part of the plasma membrane. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium channel activity | Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
| calmodulin binding | Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. |
| identical protein binding | Binding to an identical protein or proteins. |
| store-operated calcium channel activity | A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| adaptive immune response | An immune response mediated by cells expressing specific receptors for antigen produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory). |
| calcium ion import | The directed movement of calcium ions into a cell or organelle. |
| calcium ion transmembrane transport | A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. |
| mammary gland epithelium development | The process whose specific outcome is the progression of the mammary gland epithelium over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. |
| positive regulation of adenylate cyclase activity | Any process that activates or increases the frequency, rate or extent of adenylate cyclase activity. |
| positive regulation of calcium ion transport | Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| regulation of calcium ion transport | Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| store-operated calcium entry | A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q96SN7 | ORAI2 | Protein orai-2 | Homo sapiens (Human) | PR |
| Q96D31 | ORAI1 | Calcium release-activated calcium channel protein 1 | Homo sapiens (Human) | PR |
| Q8BH10 | Orai2 | Protein orai-2 | Mus musculus (Mouse) | PR |
| Q5M848 | Orai1 | Calcium release-activated calcium channel protein 1 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MHPEPAPPPS | HSNPELPVSG | GSSTSGSRRS | RRRSGDGEPS | GAPPLPPPPP | AVSYPDWIGQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SYSEVMSLNE | HSMQALSWRK | LYLSRAKLKA | SSRTSALLSG | FAMVAMVEVQ | LDTDHDYPPG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LLIVFSACTT | VLVAVHLFAL | MISTCILPNI | EAVSNVHNLN | SVKESPHERM | HRHIELAWAF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| STVIGTLLFL | AEVVLLCWVK | FLPLKRQAGQ | PSPTKPPAES | VIVANHSDSS | GITPGEAAAI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ASTAIMVPCG | LVFIVFAVHF | YRSLVSHKTD | RQFQELNELA | EFARLQDQLD | HRGDHSLTPG |
| THYA |