Q8BH10

PR
Gene name
Orai2 (Tmem142b)
Protein name
Protein orai-2
Names
Transmembrane protein 142B
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:269717
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

22-95 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8BH10

Entry ID Method Resolution Chain Position Source
AF-Q8BH10-F1 Predicted AlphaFoldDB

3 variants for Q8BH10

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388801264 95 I>N No EVA
rs3388780315 160 L>P No EVA
rs3396311253 251 V>W No EVA

No associated diseases with Q8BH10

No regional properties for Q8BH10

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q8BH10

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
  • Colocalizes with STIM1 upon store depletion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
growth cone The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

1 GO annotations of molecular function

Name Definition
store-operated calcium channel activity A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores.

1 GO annotations of biological process

Name Definition
store-operated calcium entry A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q96D31 ORAI1 Calcium release-activated calcium channel protein 1 Homo sapiens (Human) PR
Q96SN7 ORAI2 Protein orai-2 Homo sapiens (Human) PR
Q8BWG9 Orai1 Calcium release-activated calcium channel protein 1 Mus musculus (Mouse) PR
10 20 30 40 50 60
MSAELNVPMD PSAPACPEPG HKGMDYRDWV RRSYLELVTS NHHSVQALSW RKLYLSRAKL
70 80 90 100 110 120
KASSRTSALL SGFAMVAMVE VQLETKYQYP QPLLIAFSAC TTVLVAVHLF ALLISTCILP
130 140 150 160 170 180
NVEAVSNIHN LNSISESPHE RMHPYIELAW GFSTVLGILL FLAEVVLLCW IKFLPVDAKD
190 200 210 220 230 240
QPGSHSHTGW QAALVSTIIM VPVGLIFVVF TIHFYRSLVR HKTERHNREI EELHKLKVQL
DGHERSLQVV